Effects of vildagliptin (Galvus(R)) therapy in patients with type 2 diabetes mellitus after heart transplantation
Background - Type 2 Diabetes mellitus (T2DM) is a common comorbidity in patients after heart transplantation (HTx) and is associated with adverse long-term outcomes. - - Methods - The retrospective study reported here analyzed the effects of vildagliptin therapy in stable patients post-HTx with T2D...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
8 April 2013
|
| In: |
Drug design, development and therapy
Year: 2013, Jahrgang: 7, Pages: 297-303 |
| ISSN: | 1177-8881 |
| DOI: | 10.2147/DDDT.S43092 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2147/DDDT.S43092 Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623547/ 
|
| Verfasserangaben: | Ibrahim Gueler, Susanne Mueller, Matthias Helmschrott, Christian U Oeing, Christian Erbel, Lutz Frankenstein, Christian Gleißner, Arjang Ruhparwar, Philipp Ehlermann, Thomas J Dengler, Hugo A Katus, Andreas O Doesch |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1746327995 | ||
| 003 | DE-627 | ||
| 005 | 20230426174239.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210201s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2147/DDDT.S43092 |2 doi | |
| 035 | |a (DE-627)1746327995 | ||
| 035 | |a (DE-599)KXP1746327995 | ||
| 035 | |a (OCoLC)1341390014 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Güler, Ibrahim |d 1986- |e VerfasserIn |0 (DE-588)1034213318 |0 (DE-627)745124283 |0 (DE-576)381856356 |4 aut | |
| 245 | 1 | 0 | |a Effects of vildagliptin (Galvus(R)) therapy in patients with type 2 diabetes mellitus after heart transplantation |c Ibrahim Gueler, Susanne Mueller, Matthias Helmschrott, Christian U Oeing, Christian Erbel, Lutz Frankenstein, Christian Gleißner, Arjang Ruhparwar, Philipp Ehlermann, Thomas J Dengler, Hugo A Katus, Andreas O Doesch |
| 246 | 3 | 0 | |a ® Registered trademark |
| 264 | 1 | |c 8 April 2013 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Das Registered-Trade-Mark-Symbol ist in kleinerer Schriftgröße dargestellt und zwar als ein hochgestellter, eingekreister Großbuchstabe „R“, der hinter Galvus angefügt wird | ||
| 500 | |a Gesehen am 11.02.2021 | ||
| 520 | |a Background - Type 2 Diabetes mellitus (T2DM) is a common comorbidity in patients after heart transplantation (HTx) and is associated with adverse long-term outcomes. - - Methods - The retrospective study reported here analyzed the effects of vildagliptin therapy in stable patients post-HTx with T2DM and compared these with control patients for matched-pairs analysis. A total of 30 stable patients post-HTx with T2DM were included in the study. Fifteen patients (mean age 58.6 ± 6.0 years, mean time post-HTx 4.9 ± 5.3 years, twelve male and three female) were included in the vildagliptin group (VG) and 15 patients were included in the control group (CG) (mean age 61.2 ± 8.3 years, mean time post-HTx 7.2 ± 6.6 years, all male). - - Results - Mean glycated hemoglobin (HbA1c) in the VG was 7.4% ± 0.7% before versus 6.8% ± 0.8% after 8 months of vildagliptin therapy (P = 0.002 vs baseline). In the CG, HbA1c was 7.0% ± 0.7% versus 7.3% ± 1.2% at follow-up (P = 0.21). Additionally, there was a significant reduction in mean blood glucose in the VG, from 165.0 ± 18.8 mg/dL to 147.9 ± 22.7 mg/dL (P = 0.002 vs baseline), whereas mean blood glucose increased slightly in the CG from 154.7 ± 19.7 mg/dL to 162.6 ± 35.0 mg/dL (P = 0.21). No statistically significant changes in body weight (from 83.3 ± 10.8 kg to 82.0 ± 10.9 kg, P = 0.20), total cholesterol (1.5%, P = 0.68), or triglyceride levels (8.0%, P = 0.65) were seen in the VG. No significant changes in immunosuppressive drug levels or dosages were observed in either group. - - Conclusion - Vildagliptin therapy significantly reduced HbA1c and mean blood glucose levels in post-HTx patients in this study with T2DM and did not have any negative effects on lipid profile or body weight. Thus, vildagliptin therapy presented an interesting therapeutic approach for this selected patient cohort. | ||
| 700 | 1 | |a Müller, Susanne |d 1974- |e VerfasserIn |0 (DE-588)124563740 |0 (DE-627)706663756 |0 (DE-576)293873372 |4 aut | |
| 700 | 1 | |a Helmschrott, Matthias |d 1986- |e VerfasserIn |0 (DE-588)1063822068 |0 (DE-627)812634187 |0 (DE-576)423257323 |4 aut | |
| 700 | 1 | |a Oeing, Christian |d 1985- |e VerfasserIn |0 (DE-588)1148024352 |0 (DE-627)1007499877 |0 (DE-576)496150006 |4 aut | |
| 700 | 1 | |a Erbel, Christian |d 1976- |e VerfasserIn |0 (DE-588)132600927 |0 (DE-627)524413401 |0 (DE-576)299249603 |4 aut | |
| 700 | 1 | |a Frankenstein, Lutz |d 1973- |e VerfasserIn |0 (DE-588)124198937 |0 (DE-627)63440766X |0 (DE-576)328373281 |4 aut | |
| 700 | 1 | |a Gleißner, Christian A. |d 1976- |e VerfasserIn |0 (DE-588)124269907 |0 (DE-627)085750522 |0 (DE-576)294095578 |4 aut | |
| 700 | 1 | |a Ruhparwar, Arjang |e VerfasserIn |0 (DE-588)138079021 |0 (DE-627)599042591 |0 (DE-576)306325926 |4 aut | |
| 700 | 1 | |a Ehlermann, Philipp |d 1969- |e VerfasserIn |0 (DE-588)121563812 |0 (DE-627)705540855 |0 (DE-576)292774761 |4 aut | |
| 700 | 1 | |a Dengler, Thomas |e VerfasserIn |0 (DE-588)1077763050 |0 (DE-627)837469198 |0 (DE-576)184645417 |4 aut | |
| 700 | 1 | |a Katus, Hugo |d 1951- |e VerfasserIn |0 (DE-588)108916618 |0 (DE-627)577155040 |0 (DE-576)289625076 |4 aut | |
| 700 | 1 | |a Dösch, Andreas |d 1976- |e VerfasserIn |0 (DE-588)129172758 |0 (DE-627)390355798 |0 (DE-576)297522310 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Drug design, development and therapy |d Albany, Auckland : Dove Medical Press, 2007 |g 7(2013), Seite 297-303 |h Online-Ressource |w (DE-627)578533138 |w (DE-600)2451346-5 |w (DE-576)286025620 |x 1177-8881 |7 nnas |a Effects of vildagliptin (Galvus(R)) therapy in patients with type 2 diabetes mellitus after heart transplantation |
| 773 | 1 | 8 | |g volume:7 |g year:2013 |g pages:297-303 |g extent:7 |a Effects of vildagliptin (Galvus(R)) therapy in patients with type 2 diabetes mellitus after heart transplantation |
| 856 | 4 | 0 | |u https://doi.org/10.2147/DDDT.S43092 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623547/ |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210201 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 129172758 |a Dösch, Andreas |m 129172758:Dösch, Andreas |d 910000 |d 910100 |e 910000PD129172758 |e 910100PD129172758 |k 0/910000/ |k 1/910000/910100/ |p 12 |y j | ||
| 998 | |g 108916618 |a Katus, Hugo |m 108916618:Katus, Hugo |d 910000 |d 910100 |e 910000PK108916618 |e 910100PK108916618 |k 0/910000/ |k 1/910000/910100/ |p 11 | ||
| 998 | |g 1077763050 |a Dengler, Thomas |m 1077763050:Dengler, Thomas |d 50000 |e 50000PD1077763050 |k 0/50000/ |p 10 | ||
| 998 | |g 121563812 |a Ehlermann, Philipp |m 121563812:Ehlermann, Philipp |d 910000 |d 910100 |e 910000PE121563812 |e 910100PE121563812 |k 0/910000/ |k 1/910000/910100/ |p 9 | ||
| 998 | |g 138079021 |a Ruhparwar, Arjang |m 138079021:Ruhparwar, Arjang |d 910000 |d 910200 |d 50000 |e 910000PR138079021 |e 910200PR138079021 |e 50000PR138079021 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 8 | ||
| 998 | |g 124269907 |a Gleißner, Christian A. |m 124269907:Gleißner, Christian A. |d 910000 |d 910100 |e 910000PG124269907 |e 910100PG124269907 |k 0/910000/ |k 1/910000/910100/ |p 7 | ||
| 998 | |g 124198937 |a Frankenstein, Lutz |m 124198937:Frankenstein, Lutz |d 910000 |d 910100 |e 910000PF124198937 |e 910100PF124198937 |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 998 | |g 132600927 |a Erbel, Christian |m 132600927:Erbel, Christian |d 910000 |d 910100 |e 910000PE132600927 |e 910100PE132600927 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 1148024352 |a Oeing, Christian |m 1148024352:Oeing, Christian |d 50000 |e 50000PO1148024352 |k 0/50000/ |p 4 | ||
| 998 | |g 1063822068 |a Helmschrott, Matthias |m 1063822068:Helmschrott, Matthias |d 910000 |d 910100 |e 910000PH1063822068 |e 910100PH1063822068 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1034213318 |a Güler, Ibrahim |m 1034213318:Güler, Ibrahim |d 50000 |e 50000PG1034213318 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1746327995 |e 384627755X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"8 April 2013","dateIssuedKey":"2013"}],"relHost":[{"note":["Gesehen am 28.05.2020"],"pubHistory":["1.2007 -"],"language":["eng"],"part":{"volume":"7","year":"2013","pages":"297-303","extent":"7","text":"7(2013), Seite 297-303"},"disp":"Effects of vildagliptin (Galvus(R)) therapy in patients with type 2 diabetes mellitus after heart transplantationDrug design, development and therapy","type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"578533138","origin":[{"dateIssuedDisp":"2007-","publisher":"Dove Medical Press","publisherPlace":"Albany, Auckland","dateIssuedKey":"2007"}],"title":[{"title":"Drug design, development and therapy","title_sort":"Drug design, development and therapy"}],"id":{"issn":["1177-8881"],"eki":["578533138"],"zdb":["2451346-5"]},"physDesc":[{"extent":"Online-Ressource"}]}],"id":{"doi":["10.2147/DDDT.S43092"],"eki":["1746327995"]},"physDesc":[{"extent":"7 S."}],"title":[{"title_sort":"Effects of vildagliptin (Galvus(R)) therapy in patients with type 2 diabetes mellitus after heart transplantation","title":"Effects of vildagliptin (Galvus(R)) therapy in patients with type 2 diabetes mellitus after heart transplantation"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Das Registered-Trade-Mark-Symbol ist in kleinerer Schriftgröße dargestellt und zwar als ein hochgestellter, eingekreister Großbuchstabe „R“, der hinter Galvus angefügt wird","Gesehen am 11.02.2021"],"person":[{"given":"Ibrahim","display":"Güler, Ibrahim","family":"Güler","role":"aut"},{"family":"Müller","role":"aut","given":"Susanne","display":"Müller, Susanne"},{"given":"Matthias","display":"Helmschrott, Matthias","family":"Helmschrott","role":"aut"},{"given":"Christian","display":"Oeing, Christian","role":"aut","family":"Oeing"},{"given":"Christian","display":"Erbel, Christian","family":"Erbel","role":"aut"},{"role":"aut","family":"Frankenstein","given":"Lutz","display":"Frankenstein, Lutz"},{"given":"Christian A.","display":"Gleißner, Christian A.","role":"aut","family":"Gleißner"},{"family":"Ruhparwar","role":"aut","given":"Arjang","display":"Ruhparwar, Arjang"},{"role":"aut","family":"Ehlermann","given":"Philipp","display":"Ehlermann, Philipp"},{"family":"Dengler","role":"aut","given":"Thomas","display":"Dengler, Thomas"},{"role":"aut","family":"Katus","display":"Katus, Hugo","given":"Hugo"},{"given":"Andreas","display":"Dösch, Andreas","family":"Dösch","role":"aut"}],"recId":"1746327995","name":{"displayForm":["Ibrahim Gueler, Susanne Mueller, Matthias Helmschrott, Christian U Oeing, Christian Erbel, Lutz Frankenstein, Christian Gleißner, Arjang Ruhparwar, Philipp Ehlermann, Thomas J Dengler, Hugo A Katus, Andreas O Doesch"]},"language":["eng"]} | ||
| SRT | |a GUELERIBRAEFFECTSOFV8201 | ||