Tumor mutational burden as a pan-cancer biomarker for immunotherapy: the limits and potential for convergence
A recent study in The Lancet Oncology reports that high tumor mutational burden (TMB) is associated with response to anti-PD-1 pembrolizumab, leading to the second FDA approval of a tissue-agnostic predictive biomarker for immunotherapy in solid tumors. This is a step forward in realizing the full p...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 9, 2020
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| In: |
Cancer cell
Year: 2020, Jahrgang: 38, Heft: 5, Pages: 624-625 |
| ISSN: | 1878-3686 |
| DOI: | 10.1016/j.ccell.2020.10.019 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ccell.2020.10.019 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S153561082030550X 
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| Verfasserangaben: | Antonio Passaro, Albrecht Stenzinger, and Solange Peters |
| Zusammenfassung: | A recent study in The Lancet Oncology reports that high tumor mutational burden (TMB) is associated with response to anti-PD-1 pembrolizumab, leading to the second FDA approval of a tissue-agnostic predictive biomarker for immunotherapy in solid tumors. This is a step forward in realizing the full potential of cancer immunotherapy. |
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| Beschreibung: | Gesehen am 02.02.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 1878-3686 |
| DOI: | 10.1016/j.ccell.2020.10.019 |