Flux of amino acids and energy substrates across the leg in weight-stable HIV-infected patients with acute opportunistic infections: indication of a slow protein wasting process
Increased whole-body proteolysis with muscle protein net degradation has been suggested as one of the causes of weight loss in patients infected with human immunodeficiency virus (HIV). We studied the exchange rates of amino acids and energy substrates across the lower extremity in 16 HIV patients a...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
6 September 2001
|
| In: |
Journal of molecular medicine
Year: 2001, Jahrgang: 79, Heft: 11, Pages: 671-678 |
| ISSN: | 1432-1440 |
| DOI: | 10.1007/s001090100276 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s001090100276 Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s001090100276 
|
| Verfasserangaben: | Raoul Breitkreutz, Jens Wagner, Mehmet Tokus, Axel Benner, Siegbert Rossol, Nicole Pittack, Jürgen Stein, Wulf Dröge, Eggert Holm |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1747173657 | ||
| 003 | DE-627 | ||
| 005 | 20230925115940.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210203s2001 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s001090100276 |2 doi | |
| 035 | |a (DE-627)1747173657 | ||
| 035 | |a (DE-599)KXP1747173657 | ||
| 035 | |a (OCoLC)1341390271 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Breitkreutz, Raoul |e VerfasserIn |0 (DE-588)114206198 |0 (DE-627)620873620 |0 (DE-576)32047450X |4 aut | |
| 245 | 1 | 0 | |a Flux of amino acids and energy substrates across the leg in weight-stable HIV-infected patients with acute opportunistic infections |b indication of a slow protein wasting process |c Raoul Breitkreutz, Jens Wagner, Mehmet Tokus, Axel Benner, Siegbert Rossol, Nicole Pittack, Jürgen Stein, Wulf Dröge, Eggert Holm |
| 264 | 1 | |c 6 September 2001 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.02.2021 | ||
| 520 | |a Increased whole-body proteolysis with muscle protein net degradation has been suggested as one of the causes of weight loss in patients infected with human immunodeficiency virus (HIV). We studied the exchange rates of amino acids and energy substrates across the lower extremity in 16 HIV patients and 16 age-matched controls with similar body cell mass. The patients had either opportunistic infections or chronic diarrhea but no signs of clinical malnutrition. The following findings were obtained in the HIV patients: an augmented peripheral net release of arginine and lysine; an increase in both the negative arterial-venous difference and the efflux of the nitrogen contained in nonmetabolized amino acids; diminished export of 3-methylhistidine; lowered plasma and erythrocyte amino acid concentrations; reduced output of glycerol and furthermore; and neither a net release nor a net uptake of free fatty acids. The findings concerning nitrogen metabolism support the hypothesis that, in the presence of a reduction in protein breakdown, peripheral protein synthesis is severely depressed, making a slow protein wasting process likely to occur. The balances of glycerol and free fatty acids are due not only to the leg tissues but perhaps also in part to increased net retention of these substrates by skeletal muscle. | ||
| 700 | 1 | |a Wagner, Jens |d 1972- |e VerfasserIn |0 (DE-588)123654890 |0 (DE-627)706383974 |0 (DE-576)302555609 |4 aut | |
| 700 | 1 | |a Tokus, Mehmet |d 1959-2021 |e VerfasserIn |0 (DE-588)1254446796 |0 (DE-627)1796987816 |4 aut | |
| 700 | 1 | |a Benner, Axel |d 1959- |e VerfasserIn |0 (DE-588)106584686X |0 (DE-627)81687221X |0 (DE-576)425536602 |4 aut | |
| 700 | 1 | |a Rossol, Siegbert |e VerfasserIn |0 (DE-588)1106566408 |0 (DE-627)863173241 |0 (DE-576)179083627 |4 aut | |
| 700 | 1 | |a Pittack, Nicole |d 1967- |e VerfasserIn |0 (DE-588)128765267 |0 (DE-627)379137801 |0 (DE-576)187444188 |4 aut | |
| 700 | 1 | |a Stein, Jürgen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dröge, Wulf |d -2011 |e VerfasserIn |0 (DE-588)1178587789 |0 (DE-627)1049465539 |0 (DE-576)517837528 |4 aut | |
| 700 | 1 | |a Holm, Eggert |d 1936-2024 |e VerfasserIn |0 (DE-588)105156248 |0 (DE-627)588316334 |0 (DE-576)301322562 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of molecular medicine |d Berlin : Springer, 1995 |g 79(2001), 11, Seite 671-678 |h Online-Ressource |w (DE-627)254630804 |w (DE-600)1462132-0 |w (DE-576)079420028 |x 1432-1440 |7 nnas |a Flux of amino acids and energy substrates across the leg in weight-stable HIV-infected patients with acute opportunistic infections indication of a slow protein wasting process |
| 773 | 1 | 8 | |g volume:79 |g year:2001 |g number:11 |g pages:671-678 |g extent:8 |a Flux of amino acids and energy substrates across the leg in weight-stable HIV-infected patients with acute opportunistic infections indication of a slow protein wasting process |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s001090100276 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://link.springer.com/article/10.1007/s001090100276 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210203 | ||
| 993 | |a Article | ||
| 994 | |a 2001 | ||
| 998 | |g 105156248 |a Holm, Eggert |m 105156248:Holm, Eggert |d 60000 |d 61100 |e 60000PH105156248 |e 61100PH105156248 |k 0/60000/ |k 1/60000/61100/ |p 9 |y j | ||
| 998 | |g 1178587789 |a Dröge, Wulf |m 1178587789:Dröge, Wulf |d 50000 |e 50000PD1178587789 |k 0/50000/ |p 8 | ||
| 998 | |g 128765267 |a Pittack, Nicole |m 128765267:Pittack, Nicole |d 60000 |e 60000PP128765267 |k 0/60000/ |p 6 | ||
| 998 | |g 1106566408 |a Rossol, Siegbert |m 1106566408:Rossol, Siegbert |d 60000 |d 61100 |e 60000PR1106566408 |e 61100PR1106566408 |k 0/60000/ |k 1/60000/61100/ |p 5 | ||
| 998 | |g 106584686X |a Benner, Axel |m 106584686X:Benner, Axel |p 4 | ||
| 998 | |g 1254446796 |a Tokus, Mehmet |m 1254446796:Tokus, Mehmet |d 60000 |d 61100 |e 60000PT1254446796 |e 61100PT1254446796 |k 0/60000/ |k 1/60000/61100/ |p 3 | ||
| 998 | |g 123654890 |a Wagner, Jens |m 123654890:Wagner, Jens |d 60000 |e 60000PW123654890 |k 0/60000/ |p 2 | ||
| 998 | |g 114206198 |a Breitkreutz, Raoul |m 114206198:Breitkreutz, Raoul |p 1 |x j | ||
| 999 | |a KXP-PPN1747173657 |e 3848261006 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Raoul Breitkreutz, Jens Wagner, Mehmet Tokus, Axel Benner, Siegbert Rossol, Nicole Pittack, Jürgen Stein, Wulf Dröge, Eggert Holm"]},"recId":"1747173657","note":["Gesehen am 03.02.2021"],"person":[{"role":"aut","given":"Raoul","family":"Breitkreutz","display":"Breitkreutz, Raoul"},{"given":"Jens","display":"Wagner, Jens","family":"Wagner","role":"aut"},{"family":"Tokus","display":"Tokus, Mehmet","given":"Mehmet","role":"aut"},{"role":"aut","display":"Benner, Axel","family":"Benner","given":"Axel"},{"role":"aut","display":"Rossol, Siegbert","family":"Rossol","given":"Siegbert"},{"given":"Nicole","display":"Pittack, Nicole","family":"Pittack","role":"aut"},{"role":"aut","family":"Stein","display":"Stein, Jürgen","given":"Jürgen"},{"display":"Dröge, Wulf","family":"Dröge","given":"Wulf","role":"aut"},{"given":"Eggert","display":"Holm, Eggert","family":"Holm","role":"aut"}],"title":[{"title":"Flux of amino acids and energy substrates across the leg in weight-stable HIV-infected patients with acute opportunistic infections","subtitle":"indication of a slow protein wasting process","title_sort":"Flux of amino acids and energy substrates across the leg in weight-stable HIV-infected patients with acute opportunistic infections"}],"physDesc":[{"extent":"8 S."}],"relHost":[{"disp":"Flux of amino acids and energy substrates across the leg in weight-stable HIV-infected patients with acute opportunistic infections indication of a slow protein wasting processJournal of molecular medicine","pubHistory":["Volume 73, issue 1 (January 1995)-"],"note":["Gesehen am 14.03.25"],"recId":"254630804","origin":[{"publisher":"Springer","dateIssuedKey":"1995","dateIssuedDisp":"1995-","publisherPlace":"Berlin ; Heidelberg ; New York, NY"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"id":{"zdb":["1462132-0"],"issn":["1432-1440"],"eki":["254630804"]},"language":["eng"],"part":{"volume":"79","pages":"671-678","text":"79(2001), 11, Seite 671-678","year":"2001","extent":"8","issue":"11"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Journal of molecular medicine","title_sort":"Journal of molecular medicine"}]}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.1007/s001090100276"],"eki":["1747173657"]},"language":["eng"],"origin":[{"dateIssuedDisp":"6 September 2001","dateIssuedKey":"2001"}]} | ||
| SRT | |a BREITKREUTFLUXOFAMIN6200 | ||