The Drosophila proteins pelle and tube induce JNK/AP-1 activity in mammalian cells

The mammalian interleukin-1 (IL-1) signal transduction pathways display remarkable homology to the Toll signaling cascade in Drosophila. To address the question whether members of the Drosophila Toll pathway are functional in mammalian cells, inactive and constitutively active versions of the protei...

Full description

Saved in:
Bibliographic Details
Main Authors: Bacher, Susanne (Author) , Dröge, Wulf (Author)
Format: Article (Journal)
Language:English
Published: 22 May 2001
In: FEBS letters
Year: 2001, Volume: 497, Issue: 2/3, Pages: 153-158
ISSN:1873-3468
DOI:10.1016/S0014-5793(01)02454-1
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0014-5793(01)02454-1
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0014579301024541
Get full text
Author Notes:Susanne Bacher, Jörg Großhans, Wulf Dröge, M. Lienhard Schmitz

MARC

LEADER 00000caa a2200000 c 4500
001 1747190721
003 DE-627
005 20251210094051.0
007 cr uuu---uuuuu
008 210203s2001 xx |||||o 00| ||eng c
024 7 |a 10.1016/S0014-5793(01)02454-1  |2 doi 
035 |a (DE-627)1747190721 
035 |a (DE-599)KXP1747190721 
035 |a (OCoLC)1341390150 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Bacher, Susanne  |d 1964-  |e VerfasserIn  |0 (DE-588)120329069  |0 (DE-627)696573547  |0 (DE-576)292162154  |4 aut 
245 1 4 |a The Drosophila proteins pelle and tube induce JNK/AP-1 activity in mammalian cells  |c Susanne Bacher, Jörg Großhans, Wulf Dröge, M. Lienhard Schmitz 
264 1 |c 22 May 2001 
300 |a 6 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a First published online 10 May 2001 
500 |a Gesehen am 03.02.2001 
520 |a The mammalian interleukin-1 (IL-1) signal transduction pathways display remarkable homology to the Toll signaling cascade in Drosophila. To address the question whether members of the Drosophila Toll pathway are functional in mammalian cells, inactive and constitutively active versions of the protein kinase Pelle and its regulator Tube were expressed in HeLa cells and tested for their impact on IL-1-dependent signaling events. The Drosophila proteins failed to induce the IL-1-responsive transcription factor, nuclear factor-κB, but selectively activated the IL-1-regulated kinase, c-Jun N-terminal kinase (JNK), thus resulting in elevated AP-1 activity. Activation of JNK/AP-1 activity was seen upon expression of a Pelle mutant lacking its C-terminal half or by a membrane-bound and multimerised Tube protein, showing the functionality of the Drosophila proteins in mammalian cells. 
650 4 |a AP-1 
650 4 |a c-Jun N-terminal kinase 
650 4 |a Interleukin-1 signaling 
650 4 |a Nuclear factor-κB 
650 4 |a Pelle 
650 4 |a Tube 
700 1 |a Dröge, Wulf  |d -2011  |e VerfasserIn  |0 (DE-588)1178587789  |0 (DE-627)1049465539  |0 (DE-576)517837528  |4 aut 
773 0 8 |i Enthalten in  |a Vereinigung der Europäischen Biochemischen Gesellschaften  |t FEBS letters  |d Chichester : Wiley, 1968  |g 497(2001), 2/3, Seite 153-158  |h Online-Ressource  |w (DE-627)253779669  |w (DE-600)1460391-3  |w (DE-576)07279383X  |x 1873-3468  |7 nnas 
773 1 8 |g volume:497  |g year:2001  |g number:2/3  |g pages:153-158  |g extent:6  |a The Drosophila proteins pelle and tube induce JNK/AP-1 activity in mammalian cells 
856 4 0 |u https://doi.org/10.1016/S0014-5793(01)02454-1  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext  |7 1 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S0014579301024541  |x Verlag  |z lizenzpflichtig  |3 Volltext  |7 1 
951 |a AR 
992 |a 20210203 
993 |a Article 
994 |a 2001 
998 |g 1178587789  |a Dröge, Wulf  |m 1178587789:Dröge, Wulf  |d 50000  |e 50000PD1178587789  |k 0/50000/  |p 3 
999 |a KXP-PPN1747190721  |e 3848304708 
BIB |a Y 
SER |a journal 
JSO |a {"person":[{"given":"Susanne","family":"Bacher","role":"aut","display":"Bacher, Susanne","roleDisplay":"VerfasserIn"},{"family":"Dröge","given":"Wulf","display":"Dröge, Wulf","roleDisplay":"VerfasserIn","role":"aut"}],"title":[{"title":"The Drosophila proteins pelle and tube induce JNK/AP-1 activity in mammalian cells","title_sort":"Drosophila proteins pelle and tube induce JNK/AP-1 activity in mammalian cells"}],"note":["First published online 10 May 2001","Gesehen am 03.02.2001"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"recId":"1747190721","name":{"displayForm":["Susanne Bacher, Jörg Großhans, Wulf Dröge, M. Lienhard Schmitz"]},"origin":[{"dateIssuedDisp":"22 May 2001","dateIssuedKey":"2001"}],"id":{"doi":["10.1016/S0014-5793(01)02454-1"],"eki":["1747190721"]},"physDesc":[{"extent":"6 S."}],"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Vereinigung der Europäischen Biochemischen GesellschaftenFEBS letters","note":["Gesehen am 18.12.2019","Fortsetzung der Druck-Ausgabe"],"recId":"253779669","corporate":[{"display":"Vereinigung der Europäischen Biochemischen Gesellschaften","roleDisplay":"VerfasserIn","role":"aut"}],"language":["eng"],"pubHistory":["1.1968 -"],"part":{"volume":"497","text":"497(2001), 2/3, Seite 153-158","extent":"6","year":"2001","pages":"153-158","issue":"2/3"},"title":[{"subtitle":"for the rapid publication of short reports in biochemistry, biophysics, and molecular biology","title":"FEBS letters","title_sort":"FEBS letters"}],"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["Federation of European Biochemical Societies. Ed. M. Avron [u.a.]"]},"origin":[{"publisherPlace":"Chichester ; Amsterdam ; Amsterdam [u.a.]","dateIssuedDisp":"1968-","publisher":"Wiley ; North-Holland Publ. Co. ; Elsevier","dateIssuedKey":"1968"}],"id":{"issn":["1873-3468"],"zdb":["1460391-3"],"eki":["253779669"],"doi":["10.1002/(ISSN)1873-3468"]}}]} 
SRT |a BACHERSUSADROSOPHILA2220