Efficient synthesis of functionalized dithiocarbamate derivatives through one-pot three-component reaction and evaluation of their antimicrobial activities
The one-pot three-component reaction of primary and secondary amines, carbon disulfide and β-nitrostyrene derivatives in neat condition at room temperature afforded functionalized dithiocarbamate derivatives in good to high yields. High bond-forming efficiency and easy work-up are advantages of this...
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| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 January 2013
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| In: |
Journal of the Iranian Chemical Society
Year: 2013, Volume: 10, Issue: 4, Pages: 725-732 |
| ISSN: | 1735-2428 |
| DOI: | 10.1007/s13738-012-0206-0 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s13738-012-0206-0
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| Author Notes: | Elmira Ghabraie, Hamid Moghimi, Saeed Balalaie, Morteza Bararjanian, Frank Rominger, Hamid Reza Bijanzadeh |
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| 520 | |a The one-pot three-component reaction of primary and secondary amines, carbon disulfide and β-nitrostyrene derivatives in neat condition at room temperature afforded functionalized dithiocarbamate derivatives in good to high yields. High bond-forming efficiency and easy work-up are advantages of this reaction. In vitro antimicrobial activities of synthesized compounds were studied against four Gram-positive bacteria, four Gram-negative bacteria and four fungi. The screening for the antimicrobial activity was performed by twofold serial dilution technique. Notably, some synthesized compounds displayed comparable or even better antibacterial and antifungal activities against some tested strains than the reference drugs ampicillin, streptomycin and amphotericin B, respectively. | ||
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