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Dermatology life quality index and side effects after topical photodynamic therapy of actinic keratosis

<b><i>Background:</i></b> Photodynamic therapy (PDT) is an excellent treatment option for actinic keratosis. However the side effects lead to an impairment of the patients' quality of life. <b><i>Objectives:</i></b> To evaluate the impact of PDT o...

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Main Authors: Gholam, Patrick (Author) , Kröhl, Verena (Author) , Enk, Alexander (Author)
Format: Article (Journal)
Language:English
Published: June 18, 2013
In: Dermatology
Year: 2013, Volume: 226, Issue: 3, Pages: 253-259
ISSN:1421-9832
DOI:10.1159/000349992
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000349992
Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/349992
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Author Notes:Patrick Gholam, Verena Kroehl, Alexander H. Enk

MARC

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520 |a <b><i>Background:</i></b> Photodynamic therapy (PDT) is an excellent treatment option for actinic keratosis. However the side effects lead to an impairment of the patients' quality of life. <b><i>Objectives:</i></b> To evaluate the impact of PDT on patients' quality of life and to determine the frequency and intensity of side effects over the course of 4 weeks post PDT. <b><i>Patients and Methods:</i></b> 22 patients with actinic keratosis in the face were included into this prospective study. Pain was measured using a visual analog scale immediately and 8 h after PDT. The Dermatology Life Quality Index (DLQI) was assessed at screening, after treatment as well as 2 and 4 weeks after PDT. The physician and patient evaluated the intensity of side effects during the treatment, 2 and 4 weeks post PDT. Additionally, the patient documented side effects daily from the 1st to the 14th day after PDT and on day 28 post PDT, using a diary. <b><i>Results:</i></b> We observed a significant (p < 0.001) increase in the DLQI from 1.6 ± 1.7 prior to PDT to 7.3 ± 4.9 post PDT. The DLQI normalized in the following 4 weeks. Immediately and 8 h after PDT mean pain was 4.3 ± 2.5 and 2.3 ± 2.1. Side effects documented by the patients were erythema (100%), pain, burning, edema (90.9%), itching (86.4%), scaling (81.8%) and pustules (59.1%). No scar formation, hyper-/hypopigmentation or infections were observed. <b><i>Conclusion:</i></b> PDT has a significant temporary impact on patients' DLQI. Transitory side effects are common and show typical kinetics. 
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