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Nucleoside-based diarylethene photoswitches and their facile incorporation into photoswitchable DNA

Come into the light: Pyrimidine nucleosides were found to undergo fast and reversible ring closure upon irradiation with light when covalently attached to 2-[2-methyl-5-phenylthien-3-yl]cyclopent-1-ene (see scheme). Synthesis using an aqueous-phase Suzuki-Miyaura cross-coupling allows for one-step c...

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Bibliographic Details
Main Authors: Cahová, Hana (Author) , Jäschke, Andres (Author)
Format: Article (Journal)
Language:English
Published: 2013 Feb 12
In: Angewandte Chemie. International edition
Year: 2013, Volume: 52, Issue: 11, Pages: 3186-3190
ISSN:1521-3773
DOI:https://doi.org/10.1002/anie.201209943
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1002/anie.201209943
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201209943
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Author Notes:Hana Cahová and Andres Jäschke
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Summary:Come into the light: Pyrimidine nucleosides were found to undergo fast and reversible ring closure upon irradiation with light when covalently attached to 2-[2-methyl-5-phenylthien-3-yl]cyclopent-1-ene (see scheme). Synthesis using an aqueous-phase Suzuki-Miyaura cross-coupling allows for one-step conversion of iodo-modified oligonucleotides into fully reversible DNA photoswitches.
Item Description:Gesehen am 05.02.2021
Physical Description:Online Resource
ISSN:1521-3773
DOI:https://doi.org/10.1002/anie.201209943

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