IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy
Myeloid-derived suppressor cells (MDSC) are generated during tumor progression and suppress the anti-tumor functions of T and natural killer (NK) cells. Their enrichment is associated with a bad prognosis and a worse outcome of immunotherapy in cancer patients. The cytokine interleukin (IL)-6 was fo...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 2021
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| In: |
Cellular immunology
Year: 2021, Volume: 359, Pages: 1-8 |
| ISSN: | 1090-2163 |
| DOI: | 10.1016/j.cellimm.2020.104254 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cellimm.2020.104254 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0008874920304147 
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| Author Notes: | Rebekka Weber, Christopher Groth, Samantha Lasser, Ihor Arkhypov, Vera Petrova, Peter Altevogt, Jochen Utikal, Viktor Umansky |
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| 520 | |a Myeloid-derived suppressor cells (MDSC) are generated during tumor progression and suppress the anti-tumor functions of T and natural killer (NK) cells. Their enrichment is associated with a bad prognosis and a worse outcome of immunotherapy in cancer patients. The cytokine interleukin (IL)-6 was found to be a crucial regulator of MDSC accumulation and activation as well as a factor, stimulating tumor cell proliferation, survival, invasiveness and metastasis. Accordingly, IL-6 can serve as a negative prognostic marker in cancer. On the other hand, this cytokine is also involved in T cell activation. This review discusses the pleiotropic effects of IL-6 on immune cell populations that are critical for tumor development, such as MDSC and T cells, and summarizes the data on targeting IL-6 or IL-6 receptor (IL-6R) for tumor immunotherapy to block MDSC-mediated immunosuppression in cancer patients. | ||
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