Structural heterogeneity of a human norovirus vaccine candidate
Human norovirus virus-like particles (VLPs) are assumed to be morphologically and antigenically similar to virion particles. The norovirus virion is assembled from 180 copies of the capsid protein (VP1) and exhibits T = 3 icosahedral symmetry. In this study, we showed that the vaccine candidate GII....
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2021
|
| In: |
Virology
Year: 2020, Jahrgang: 553, Pages: 23-34 |
| ISSN: | 1096-0341 |
| DOI: | 10.1016/j.virol.2020.10.005 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.virol.2020.10.005 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0042682220302063 
|
| Verfasserangaben: | Jessica M. Devant, Grant S. Hansman |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1747719099 | ||
| 003 | DE-627 | ||
| 005 | 20240411193354.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210208r20212020xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.virol.2020.10.005 |2 doi | |
| 035 | |a (DE-627)1747719099 | ||
| 035 | |a (DE-599)KXP1747719099 | ||
| 035 | |a (OCoLC)1341391737 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Devant, Jessica |d 1992- |e VerfasserIn |0 (DE-588)1189452464 |0 (DE-627)1668103915 |4 aut | |
| 245 | 1 | 0 | |a Structural heterogeneity of a human norovirus vaccine candidate |c Jessica M. Devant, Grant S. Hansman |
| 264 | 1 | |c 2021 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 28 October 2020 | ||
| 500 | |a Gesehen am 08.02.2021 | ||
| 520 | |a Human norovirus virus-like particles (VLPs) are assumed to be morphologically and antigenically similar to virion particles. The norovirus virion is assembled from 180 copies of the capsid protein (VP1) and exhibits T = 3 icosahedral symmetry. In this study, we showed that the vaccine candidate GII.4c VP1 formed T = 1 and T = 3 VLPs, but mainly assembled into T = 4 icosahedral particles that were composed of 240 VP1 copies. In contrast, another clinically important genotype, GII.17, almost exclusively folded into T = 3 VLPs. Interestingly, the GII.4c T = 1 particles had higher binding capacities to norovirus-specific Nanobodies than to GII.4c T = 3 and T = 4 particles. Our data indicated that the occluded Nanobody-binding epitopes on the T = 1 particles were more accessible compared to the larger T = 3 and T = 4 particles. Overall, this new data revealed that GII.4c VLPs had a preference for forming the T = 4 icosahedral symmetry and future studies with varied sized norovirus VLPs should take caution when examining antigenicity. | ||
| 534 | |c 2020 | ||
| 650 | 4 | |a Cryo-EM | |
| 650 | 4 | |a Norovirus | |
| 650 | 4 | |a Vaccine | |
| 700 | 1 | |a Hansman, Grant S. |e VerfasserIn |0 (DE-588)105917703X |0 (DE-627)798127287 |0 (DE-576)325655553 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Virology |d San Diego, Calif. [u.a.] : Elsevier, 1955 |g 553(2021), Seite 23-34 |h Online-Ressource |w (DE-627)268130248 |w (DE-600)1471925-3 |w (DE-576)104194081 |x 1096-0341 |7 nnas |a Structural heterogeneity of a human norovirus vaccine candidate |
| 773 | 1 | 8 | |g volume:553 |g year:2021 |g pages:23-34 |g extent:12 |a Structural heterogeneity of a human norovirus vaccine candidate |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.virol.2020.10.005 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0042682220302063 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210208 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 105917703X |a Hansman, Grant S. |m 105917703X:Hansman, Grant S. |d 910000 |d 911700 |e 910000PH105917703X |e 911700PH105917703X |k 0/910000/ |k 1/910000/911700/ |p 2 |y j | ||
| 998 | |g 1189452464 |a Devant, Jessica |m 1189452464:Devant, Jessica |d 910000 |d 911700 |e 910000PD1189452464 |e 911700PD1189452464 |k 0/910000/ |k 1/910000/911700/ |p 1 |x j | ||
| 999 | |a KXP-PPN1747719099 |e 3849731022 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Available online 28 October 2020","Gesehen am 08.02.2021"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1747719099","language":["eng"],"title":[{"title_sort":"Structural heterogeneity of a human norovirus vaccine candidate","title":"Structural heterogeneity of a human norovirus vaccine candidate"}],"person":[{"family":"Devant","given":"Jessica","display":"Devant, Jessica","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Hansman, Grant S.","roleDisplay":"VerfasserIn","given":"Grant S.","family":"Hansman"}],"physDesc":[{"extent":"12 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1096-0341"],"eki":["268130248"],"zdb":["1471925-3"]},"origin":[{"publisherPlace":"San Diego, Calif. [u.a.] ; Orlando, Fla.","dateIssuedDisp":"1955-","publisher":"Elsevier ; Academic Press","dateIssuedKey":"1955"}],"language":["eng"],"recId":"268130248","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 12.08.20"],"disp":"Structural heterogeneity of a human norovirus vaccine candidateVirology","part":{"pages":"23-34","year":"2021","extent":"12","volume":"553","text":"553(2021), Seite 23-34"},"pubHistory":["1.1955 -"],"title":[{"title_sort":"Virology","title":"Virology"}]}],"origin":[{"dateIssuedDisp":"2021","dateIssuedKey":"2021"}],"id":{"eki":["1747719099"],"doi":["10.1016/j.virol.2020.10.005"]},"name":{"displayForm":["Jessica M. Devant, Grant S. Hansman"]}} | ||
| SRT | |a DEVANTJESSSTRUCTURAL2021 | ||