Synthesis of 3'-deoxy-3'-(18F)fluoro-thymidine with 2,3'-anhydro-5'-O-(4,4'-dimethoxytrityl)-thymidine
[11C]Thymidine has been used as a proliferation marker in positron-emission-tomography (PET) studies of tumors. This compound showed metabolite related problems and the radiosynthesis proved to be difficult. Recently, the more stable 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) has been suggested as...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Französisch |
| Veröffentlicht: |
30 October 2000
|
| In: |
Journal of labelled compounds and radiopharmaceuticals
Year: 2000, Jahrgang: 43, Heft: 12, Pages: 1211-1218 |
| ISSN: | 1099-1344 |
| DOI: | 10.1002/1099-1344(20001030)43:12<1211::AID-JLCR408>3.0.CO;2-# |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/1099-1344(20001030)43:12<1211::AID-JLCR408>3.0.CO;2-%23 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/1099-1344%2820001030%2943%3A12%3C1211%3A%3AAID-JLCR408%3E3.0.CO%3B2-%23 
|
| Verfasserangaben: | C. Wodarski, J. Eisenbarth, K. Weber, M. Henze, U. Haberkorn and M. Eisenhut |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1747881597 | ||
| 003 | DE-627 | ||
| 005 | 20240115092450.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210209s2000 xx |||||o 00| ||fre c | ||
| 024 | 7 | |a 10.1002/1099-1344(20001030)43:12<1211::AID-JLCR408>3.0.CO;2-%23 |2 doi | |
| 035 | |a (DE-627)1747881597 | ||
| 035 | |a (DE-599)KXP1747881597 | ||
| 035 | |a (OCoLC)1341391969 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a fre | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wodarski, Christine |d 1965-2017 |e VerfasserIn |0 (DE-588)122680389X |0 (DE-627)1747880361 |4 aut | |
| 245 | 1 | 0 | |a Synthesis of 3'-deoxy-3'-(18F)fluoro-thymidine with 2,3'-anhydro-5'-O-(4,4'-dimethoxytrityl)-thymidine |c C. Wodarski, J. Eisenbarth, K. Weber, M. Henze, U. Haberkorn and M. Eisenhut |
| 246 | 3 | 3 | |a Synthesis of 3'-deoxy-3'- (18 F)fluoro-thymidine with 2,3'-anhydro-5'-O-(4,4'-dimethoxytrityl)-thymidine |
| 264 | 1 | |c 30 October 2000 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Im Titel steht der Ausdruck (18F) in eckiger Klammer, die Zahl 18 ist dabei hochgestellt | ||
| 500 | |a Gesehen am 09.02.2021 | ||
| 520 | |a [11C]Thymidine has been used as a proliferation marker in positron-emission-tomography (PET) studies of tumors. This compound showed metabolite related problems and the radiosynthesis proved to be difficult. Recently, the more stable 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) has been suggested as an alternative. One advantage of [18F]FLT is based on thymidine kinase-1 catalyzed phosphorylation of FLT and the intracellular accumulation of this metabolite without participation in DNA synthesis. The radiosynthesis of [18F]FLT originally designed by Grierson et al. was found to be demanding especially regarding the workup of the [18F]fluoride/1-(2-deoxy-3-O-nosyl-5-O-DMT-β-D-threo-pento-furanosyl)-3-DMBn-thymine reaction mixture. Instead, we used 2,3′-anhydro-5′-O-(4,4′-dimethoxytrityl)thymidine as a precursor for the synthesis of [18F]FLT. In DMSO at 175°C and in presence of Kryptofix® 2.2.2. we obtained 5.6± 1,4% [18F]FLT (EOS). Copyright © 2000 John Wiley & Sons, Ltd. | ||
| 650 | 4 | |a 18FFLT | |
| 650 | 4 | |a 2 | |
| 650 | 4 | |a 3′-anhydro-5′-O-(4 | |
| 650 | 4 | |a 4′-dimethoxytrityl)-thymidine | |
| 650 | 4 | |a PET imaging | |
| 650 | 4 | |a Proliferation Marker | |
| 700 | 1 | |a Eisenbarth, Joseph |e VerfasserIn |0 (DE-588)1226804454 |0 (DE-627)1747880833 |4 aut | |
| 700 | 1 | |a Weber, Klaus-Josef |d 1951- |e VerfasserIn |0 (DE-588)112804373 |0 (DE-627)691161224 |0 (DE-576)289743125 |4 aut | |
| 700 | 1 | |a Henze, Marcus |e VerfasserIn |0 (DE-588)1076102921 |0 (DE-627)834307081 |0 (DE-576)175599408 |4 aut | |
| 700 | 1 | |a Haberkorn, Uwe |d 1959- |e VerfasserIn |0 (DE-588)1022913905 |0 (DE-627)717331245 |0 (DE-576)366166352 |4 aut | |
| 700 | 1 | |a Eisenhut, Michael |e VerfasserIn |0 (DE-588)1113306122 |0 (DE-627)867174501 |0 (DE-576)160846080 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of labelled compounds and radiopharmaceuticals |d New York, NY [u.a.] : Wiley, 1965 |g 43(2000), 12, Seite 1211-1218 |h Online-Ressource |w (DE-627)302718206 |w (DE-600)1491841-9 |w (DE-576)09542816X |x 1099-1344 |7 nnas |a Synthesis of 3'-deoxy-3'-(18F)fluoro-thymidine with 2,3'-anhydro-5'-O-(4,4'-dimethoxytrityl)-thymidine |
| 773 | 1 | 8 | |g volume:43 |g year:2000 |g number:12 |g pages:1211-1218 |g extent:8 |a Synthesis of 3'-deoxy-3'-(18F)fluoro-thymidine with 2,3'-anhydro-5'-O-(4,4'-dimethoxytrityl)-thymidine |
| 856 | 4 | 0 | |u https://doi.org/10.1002/1099-1344(20001030)43:12<1211::AID-JLCR408>3.0.CO;2-%23 |x Verlag |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/1099-1344%2820001030%2943%3A12%3C1211%3A%3AAID-JLCR408%3E3.0.CO%3B2-%23 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210209 | ||
| 993 | |a Article | ||
| 994 | |a 2000 | ||
| 998 | |g 1113306122 |a Eisenhut, Michael |m 1113306122:Eisenhut, Michael |d 50000 |e 50000PE1113306122 |k 0/50000/ |p 6 |y j | ||
| 998 | |g 1022913905 |a Haberkorn, Uwe |m 1022913905:Haberkorn, Uwe |d 910000 |d 911400 |e 910000PH1022913905 |e 911400PH1022913905 |k 0/910000/ |k 1/910000/911400/ |p 5 | ||
| 998 | |g 1076102921 |a Henze, Marcus |m 1076102921:Henze, Marcus |d 50000 |e 50000PH1076102921 |k 0/50000/ |p 4 | ||
| 998 | |g 112804373 |a Weber, Klaus-Josef |m 112804373:Weber, Klaus-Josef |d 910000 |d 911400 |e 910000PW112804373 |e 911400PW112804373 |k 0/910000/ |k 1/910000/911400/ |p 3 | ||
| 999 | |a KXP-PPN1747881597 |e 3850326756 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1747881597","origin":[{"dateIssuedDisp":"30 October 2000","dateIssuedKey":"2000"}],"name":{"displayForm":["C. Wodarski, J. Eisenbarth, K. Weber, M. Henze, U. Haberkorn and M. Eisenhut"]},"person":[{"role":"aut","family":"Wodarski","given":"Christine","display":"Wodarski, Christine"},{"role":"aut","display":"Eisenbarth, Joseph","given":"Joseph","family":"Eisenbarth"},{"role":"aut","given":"Klaus-Josef","display":"Weber, Klaus-Josef","family":"Weber"},{"role":"aut","given":"Marcus","display":"Henze, Marcus","family":"Henze"},{"role":"aut","display":"Haberkorn, Uwe","given":"Uwe","family":"Haberkorn"},{"given":"Michael","display":"Eisenhut, Michael","family":"Eisenhut","role":"aut"}],"titleAlt":[{"title":"Synthesis of 3'-deoxy-3'- (18 F)fluoro-thymidine with 2,3'-anhydro-5'-O-(4,4'-dimethoxytrityl)-thymidine"}],"language":["fre"],"title":[{"title":"Synthesis of 3'-deoxy-3'-(18F)fluoro-thymidine with 2,3'-anhydro-5'-O-(4,4'-dimethoxytrityl)-thymidine","title_sort":"Synthesis of 3'-deoxy-3'-(18F)fluoro-thymidine with 2,3'-anhydro-5'-O-(4,4'-dimethoxytrityl)-thymidine"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1002/1099-1344(20001030)43:12<1211::AID-JLCR408>3.0.CO;2-%23"],"eki":["1747881597"]},"physDesc":[{"extent":"8 S."}],"relHost":[{"note":["Gesehen am 27.02.08"],"part":{"volume":"43","text":"43(2000), 12, Seite 1211-1218","year":"2000","pages":"1211-1218","extent":"8","issue":"12"},"id":{"issn":["1099-1344"],"doi":["10.1002/(ISSN)1099-1344"],"zdb":["1491841-9"],"eki":["302718206"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Journal of labelled compounds and radiopharmaceuticals","subtitle":"the official journal of the International Isotope Society","title_sort":"Journal of labelled compounds and radiopharmaceuticals"}],"origin":[{"publisherPlace":"New York, NY [u.a.]","dateIssuedKey":"1965","dateIssuedDisp":"1965-","publisher":"Wiley"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.1965 -"],"titleAlt":[{"title":"Journal of labelled compounds"}],"language":["eng"],"disp":"Synthesis of 3'-deoxy-3'-(18F)fluoro-thymidine with 2,3'-anhydro-5'-O-(4,4'-dimethoxytrityl)-thymidineJournal of labelled compounds and radiopharmaceuticals","recId":"302718206"}],"note":["Im Titel steht der Ausdruck (18F) in eckiger Klammer, die Zahl 18 ist dabei hochgestellt","Gesehen am 09.02.2021"]} | ||
| SRT | |a WODARSKICHSYNTHESISO3020 | ||