A convenient route for the preparation of peptide nucleic acid monomers carrying acid-labile groups for the protection of the amino function
A convenient route for the preparation of peptide nucleic acid (PNA) monomers is described. Two different baselabile protecting groups (2-cyanoethyl and 4-nitrophenylethyl) are described for the protection of the carboxylic function of theN-(2-aminoethyl)glycine backbone during the assembly of the m...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 1999
|
| In: |
Letters in peptide science
Year: 1999, Volume: 6, Issue: 4, Pages: 209-219 |
| ISSN: | 1573-496X |
| DOI: | 10.1007/BF02443508 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/BF02443508
|
| Author Notes: | Elisenda Ferrer, Michael Eisenhut & Ramon Eritja |
| Summary: | A convenient route for the preparation of peptide nucleic acid (PNA) monomers is described. Two different baselabile protecting groups (2-cyanoethyl and 4-nitrophenylethyl) are described for the protection of the carboxylic function of theN-(2-aminoethyl)glycine backbone during the assembly of the monomers. These groups are selectively removed yielding the desired PNA monomers in high yields, the 2-cyanoethyl group being faster and cleaner than the 4-nitrophenylethyl group. The use of PNA monomers for the preparation of DNA-PNA chimeric molecules is also discussed. |
|---|---|
| Item Description: | Gesehen am 09.02.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1573-496X |
| DOI: | 10.1007/BF02443508 |