A convenient route for the preparation of peptide nucleic acid monomers carrying acid-labile groups for the protection of the amino function
A convenient route for the preparation of peptide nucleic acid (PNA) monomers is described. Two different baselabile protecting groups (2-cyanoethyl and 4-nitrophenylethyl) are described for the protection of the carboxylic function of theN-(2-aminoethyl)glycine backbone during the assembly of the m...
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 1999
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| In: |
Letters in peptide science
Year: 1999, Jahrgang: 6, Heft: 4, Pages: 209-219 |
| ISSN: | 1573-496X |
| DOI: | 10.1007/BF02443508 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/BF02443508
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| Verfasserangaben: | Elisenda Ferrer, Michael Eisenhut & Ramon Eritja |
MARC
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| 520 | |a A convenient route for the preparation of peptide nucleic acid (PNA) monomers is described. Two different baselabile protecting groups (2-cyanoethyl and 4-nitrophenylethyl) are described for the protection of the carboxylic function of theN-(2-aminoethyl)glycine backbone during the assembly of the monomers. These groups are selectively removed yielding the desired PNA monomers in high yields, the 2-cyanoethyl group being faster and cleaner than the 4-nitrophenylethyl group. The use of PNA monomers for the preparation of DNA-PNA chimeric molecules is also discussed. | ||
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