Crystalloid lysozyme inclusions in Paneth cells of vitamin A-deficient rats

The effect of vitamin A-deficiency on jejunal Paneth cells in rats was investigated. Crystalloid particles were observed in secretion granules of Paneth cells from 6 out of 8 rats with vitamin A-deficiency. The particles were similar to those found in Paneth cells under other experimental conditions...

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Hauptverfasser: Koch, Martin Jean (VerfasserIn) , Biesalski, Hans-Konrad (VerfasserIn) , Stofft, Eckart (VerfasserIn) , Weiser, Harald (VerfasserIn) , Gabbert, Helmut E. (VerfasserIn) , Dienes, Hans-P. (VerfasserIn) , Schulz-Dobrick, Burkard (VerfasserIn) , Bässler, Karl H. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: January 1990
In: Cell & tissue research
Year: 1990, Jahrgang: 260, Heft: 3, Pages: 625-628
ISSN:1432-0878
DOI:10.1007/BF00297244
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/BF00297244
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Verfasserangaben:Martin J. Koch, Hans K. Biesalski, Eckart Stofft, Harald Weiser, Helmut E. Gabbert, Hans-P. Dienes, Burkard Schulz-Dobrick, and Karl H. Bässler

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520 |a The effect of vitamin A-deficiency on jejunal Paneth cells in rats was investigated. Crystalloid particles were observed in secretion granules of Paneth cells from 6 out of 8 rats with vitamin A-deficiency. The particles were similar to those found in Paneth cells under other experimental conditions. Using an immuno-electron-microscopic technique we demonstrated a clear lysozyme immunoreactivity of these particles. In 2 vitamin A-deficient rats tubular structures have been detected in addition to the crystalloid particles. Crystalloid particles or tubular structures were not detectable in a control group of 8 vitamin A-supplemented rats. The morphological alterations of Paneth cells may be correlated to an impaired local immunity of the intestine during vitamin A-deficiency. 
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