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Oncogenic transformation-dependent expression of a transcription factor NF-Y subunit

As a result of differential splicing, one subunit of the nuclear factor Y (NF-Y) consists of two major isoforms designated short (NF-YaS) and long (NF-YaL). In proliferating normal human fibroblasts, NF-YaL is by far the more expressed isoform. Surprisingly, NF-YaS was found by immunoblotting to be...

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Bibliographic Details
Main Authors: Gu, Zhennan (Author) , Rommelaere, Jean (Author)
Format: Article (Journal)
Language:English
Published: 07 May 1999
In: Molecular carcinogenesis
Year: 1999, Volume: 24, Issue: 4, Pages: 294-299
ISSN:1098-2744
DOI:https://doi.org/10.1002/(SICI)1098-2744(199904)24:4<294::AID-MC7>3.0.CO;2-Q
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1002/(SICI)1098-2744(199904)24:4<294::AID-MC7>3.0.CO;2-Q
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291098-2744%28199904%2924%3A4%3C294%3A%3AAID-MC7%3E3.0.CO%3B2-Q
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Author Notes:Zhennan Gu, Gaëlle Kuntz‐Simon, Jean Rommelaere, and Jan Cornelis

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520 |a As a result of differential splicing, one subunit of the nuclear factor Y (NF-Y) consists of two major isoforms designated short (NF-YaS) and long (NF-YaL). In proliferating normal human fibroblasts, NF-YaL is by far the more expressed isoform. Surprisingly, NF-YaS was found by immunoblotting to be as prominent as NF-YaL in simian virus 40 (SV40)-transformed cell derivatives. As a consequence, two NF-Y/DNA complexes, one containing the long and the other the short isoform, were formed with extracts from transformed cells and a target promoter element in electrophoretic mobility-shift assays. Only the complex containing NF-YaL was detected with extracts from normal fibroblasts. Furthermore, the NF-Y recognition motif contributed to promoter activation in SV40-transformed cells but not in normal, cells. Our finding links transcription stimulation in transformed cells to quantitative changes in the expression of an NF-Ya subunit. 
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