Neoplastic transformation-associated stimulation of the in vitro resolution of concatemer junction fragments from minute virus of mice DNA
Minute virus of mice (MVM) shows an oncotropic behavior reflected by its ability to amplify its genome more efficiently in a number of transformed versus normal cells. In vivo and in vitro studies revealed that the major effect of cell transformation on MVM DNA replication occurs at the level of dou...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 1, 1999
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| In: |
Journal of virology
Year: 1999, Volume: 73, Issue: 3, Pages: 2552-2558 |
| ISSN: | 1098-5514 |
| DOI: | 10.1128/JVI.73.3.2552-2558.1999 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1128/JVI.73.3.2552-2558.1999 Verlag, lizenzpflichtig, Volltext: https://jvi.asm.org/content/73/3/2552 
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| Author Notes: | Gaëlle Kuntz-Simon, Tarig Bashir, Jean Rommelaere, and Kurt Willwand |
| Summary: | Minute virus of mice (MVM) shows an oncotropic behavior reflected by its ability to amplify its genome more efficiently in a number of transformed versus normal cells. In vivo and in vitro studies revealed that the major effect of cell transformation on MVM DNA replication occurs at the level of double-stranded replicative-form amplification. In particular, resolution of MVM DNA concatemers into monomers was found to be highly sensitive to neoplastic transformation. |
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| Item Description: | Gesehen am 11.02.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1098-5514 |
| DOI: | 10.1128/JVI.73.3.2552-2558.1999 |