Satellite microglia show spontaneous electrical activity that is uncorrelated with activity of the attached neuron
Microglia are innate immune cells of the brain. We have studied a subpopulation of microglia, called satellite microglia. This cell type is defined by a close morphological soma-to-soma association with a neuron, indicative of a direct functional interaction. Indeed, ultrastructural analysis reveale...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
08 April 2016
|
| In: |
European journal of neuroscience
Year: 2016, Jahrgang: 43, Heft: 11, Pages: 1523-1534 |
| ISSN: | 1460-9568 |
| DOI: | https://doi.org/10.1111/ejn.13256 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1111/ejn.13256 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.13256 
|
| Verfasserangaben: | Emile Wogram, Stefan Wendt, Marina Matyash, Tatyana Pivneva, Andreas Draguhn and Helmut Kettenmann |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1748081985 | ||
| 003 | DE-627 | ||
| 005 | 20220819103328.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210211s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/ejn.13256 |2 doi | |
| 035 | |a (DE-627)1748081985 | ||
| 035 | |a (DE-599)KXP1748081985 | ||
| 035 | |a (OCoLC)1341392426 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wogram, Emile |e VerfasserIn |0 (DE-588)1147773874 |0 (DE-627)1007173351 |0 (DE-576)496024884 |4 aut | |
| 245 | 1 | 0 | |a Satellite microglia show spontaneous electrical activity that is uncorrelated with activity of the attached neuron |c Emile Wogram, Stefan Wendt, Marina Matyash, Tatyana Pivneva, Andreas Draguhn and Helmut Kettenmann |
| 264 | 1 | |c 08 April 2016 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.02.2021 | ||
| 520 | |a Microglia are innate immune cells of the brain. We have studied a subpopulation of microglia, called satellite microglia. This cell type is defined by a close morphological soma-to-soma association with a neuron, indicative of a direct functional interaction. Indeed, ultrastructural analysis revealed closely attached plasma membranes of satellite microglia and neurons. However, we found no apparent morphological specializations of the contact, and biocytin injection into satellite microglia showed no dye-coupling with the apposed neurons or any other cell. Likewise, evoked local field potentials or action potentials and postsynaptic potentials of the associated neuron did not lead to any transmembrane currents or non-capacitive changes in the membrane potential of the satellite microglia in the cortex and hippocampus. Both satellite and non-satellite microglia, however, showed spontaneous transient membrane depolarizations that were not correlated with neuronal activity. These events could be divided into fast-rising and slow-rising depolarizations, which showed different characteristics in satellite and non-satellite microglia. Fast-rising and slow-rising potentials differed with regard to voltage dependence. The frequency of these events was not affected by the application of tetrodotoxin, but the fast-rising event frequency decreased after application of GABA. We conclude that microglia show spontaneous electrical activity that is uncorrelated with the activity of adjacent neurons. | ||
| 650 | 4 | |a electrical activity | |
| 650 | 4 | |a identified neurons | |
| 650 | 4 | |a membrane potential | |
| 650 | 4 | |a satellite microglia | |
| 700 | 1 | |a Wendt, Stefan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Matyash, Marina |d 1968- |e VerfasserIn |0 (DE-588)1146359845 |0 (DE-627)1007881550 |0 (DE-576)185057306 |4 aut | |
| 700 | 1 | |a Pivneva, Tatyana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Draguhn, Andreas |d 1961- |e VerfasserIn |0 (DE-588)121130282 |0 (DE-627)081107102 |0 (DE-576)292552394 |4 aut | |
| 700 | 1 | |a Kettenmann, Helmut |d 1955- |e VerfasserIn |0 (DE-588)1034238280 |0 (DE-627)745147526 |0 (DE-576)381876144 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of neuroscience |d Oxford [u.a.] : Wiley, 1989 |g 43(2016), 11, Seite 1523-1534 |h Online-Ressource |w (DE-627)320443299 |w (DE-600)2005178-5 |w (DE-576)090954696 |x 1460-9568 |7 nnas |a Satellite microglia show spontaneous electrical activity that is uncorrelated with activity of the attached neuron |
| 773 | 1 | 8 | |g volume:43 |g year:2016 |g number:11 |g pages:1523-1534 |g extent:12 |a Satellite microglia show spontaneous electrical activity that is uncorrelated with activity of the attached neuron |
| 856 | 4 | 0 | |u https://doi.org/https://doi.org/10.1111/ejn.13256 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.13256 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210211 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 121130282 |a Draguhn, Andreas |m 121130282:Draguhn, Andreas |d 50000 |d 53200 |e 50000PD121130282 |e 53200PD121130282 |k 0/50000/ |k 1/50000/53200/ |p 5 | ||
| 998 | |g 1147773874 |a Wogram, Emile |m 1147773874:Wogram, Emile |d 50000 |e 50000PW1147773874 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1748081985 |e 3851268814 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Wogram, Emile","family":"Wogram","given":"Emile","role":"aut"},{"display":"Wendt, Stefan","family":"Wendt","given":"Stefan","role":"aut"},{"role":"aut","given":"Marina","family":"Matyash","display":"Matyash, Marina"},{"display":"Pivneva, Tatyana","family":"Pivneva","role":"aut","given":"Tatyana"},{"given":"Andreas","role":"aut","family":"Draguhn","display":"Draguhn, Andreas"},{"display":"Kettenmann, Helmut","family":"Kettenmann","given":"Helmut","role":"aut"}],"title":[{"title_sort":"Satellite microglia show spontaneous electrical activity that is uncorrelated with activity of the attached neuron","title":"Satellite microglia show spontaneous electrical activity that is uncorrelated with activity of the attached neuron"}],"physDesc":[{"extent":"12 S."}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.1111/ejn.13256"],"eki":["1748081985"]},"origin":[{"dateIssuedDisp":"08 April 2016","dateIssuedKey":"2016"}],"name":{"displayForm":["Emile Wogram, Stefan Wendt, Marina Matyash, Tatyana Pivneva, Andreas Draguhn and Helmut Kettenmann"]},"recId":"1748081985","note":["Gesehen am 11.02.2021"],"relHost":[{"title":[{"title":"European journal of neuroscience","subtitle":"EJN","title_sort":"European journal of neuroscience"}],"pubHistory":["1.1989 -"],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"titleAlt":[{"title":"EJN"}],"note":["Gesehen am 03.05.06"],"part":{"issue":"11","year":"2016","volume":"43","pages":"1523-1534","extent":"12","text":"43(2016), 11, Seite 1523-1534"},"id":{"doi":["10.1111/(ISSN)1460-9568"],"eki":["320443299"],"zdb":["2005178-5"],"issn":["1460-9568"]},"origin":[{"dateIssuedKey":"1989","publisher":"Wiley ; Blackwell Science ; Blackwell","dateIssuedDisp":"1989-","publisherPlace":"Oxford [u.a.] ; Oxford ; Oxford [u.a.]"}],"disp":"Satellite microglia show spontaneous electrical activity that is uncorrelated with activity of the attached neuronEuropean journal of neuroscience","name":{"displayForm":["European Neuroscience Association"]},"recId":"320443299"}]} | ||
| SRT | |a WOGRAMEMILSATELLITEM0820 | ||