Siglec-1-positive plasmacytoid dendritic cells (pDCs) in human peripheral blood: a semi-mature and myeloid-like subset imbalanced during protective and autoimmune responses
Plasmacytoid dendritic cells (pDCs) play a central role in the pathogenesis of systemic lupus erythematosus (SLE) as IFN-α producers and promoters of T-cell activation or tolerance. Here, we demonstrated by flow-cytometry and confocal microscopy that Siglec-1, a molecule involved in the regulation o...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2016
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| In: |
Clinical immunology
Year: 2015, Volume: 163, Pages: 42-51 |
| ISSN: | 1521-7035 |
| DOI: | 10.1016/j.clim.2015.12.001 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.clim.2015.12.001 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S152166161530070X 
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| Author Notes: | Theresa R. Wilhelm, Adriano Taddeo, Oliver Winter, Axel Ronald Schulz, Julia-Nora Mälzer, Cristina Domingo, Robert Biesen, Tobias Alexander, Andreas Thiel, Andreas Radbruch, Falk Hiepe, Velia Gerl |
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| 520 | |a Plasmacytoid dendritic cells (pDCs) play a central role in the pathogenesis of systemic lupus erythematosus (SLE) as IFN-α producers and promoters of T-cell activation or tolerance. Here, we demonstrated by flow-cytometry and confocal microscopy that Siglec-1, a molecule involved in the regulation of adaptive immunoresponses, is expressed in a subset of semi-mature, myeloid-like pDCs in human blood. These pDCs express lower BDCA-2 and CD123 and higher HLA-DR and CD11c than Siglec-1-negative pDCs and do not produce IFN-α via TLR7/TLR9 engagement. In vitro, Siglec-1 expression was induced in Siglec-1-negative pDCs by influenza virus. Proportions of Siglec-1-positive/Siglec-1-negative pDCs were higher in SLE than in healthy controls and correlated with disease activity. Healthy donors immunized with yellow fever vaccine YFV-17D displayed different kinetics of the two pDC subsets during protective immune response. PDCs can be subdivided into two subsets according to Siglec-1 expression. These subsets may play specific roles in (auto)immune responses. | ||
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| 650 | 4 | |a Erythematosus | |
| 650 | 4 | |a Plasmacytoide dendritic cell | |
| 650 | 4 | |a Siglec-1 | |
| 650 | 4 | |a Systemic lupus | |
| 700 | 1 | |a Taddeo, Adriano |e VerfasserIn |4 aut | |
| 700 | 1 | |a Winter, Oliver |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schulz, Axel Ronald |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mälzer, Julia-Nora |e VerfasserIn |4 aut | |
| 700 | 1 | |a Domingo, Cristina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Biesen, Robert |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Thiel, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Radbruch, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hiepe, Falk |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gerl, Velia |e VerfasserIn |4 aut | |
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