How specific are non-motor symptoms in the prodrome of Parkinson's disease compared to other movement disorders?
The clinical diagnosis of Parkinson's disease (PD) based on motor signs is often preceded by several non-motor symptoms that can indicate early prodromal neurodegenerative processes. Such prodromal symptoms can aid the early detection of PD, but their specificity for prodromal PD in comparison...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 October 2020
|
| In: |
Parkinsonism & related disorders
Year: 2020, Volume: 81, Pages: 213-218 |
| ISSN: | 1873-5126 |
| DOI: | 10.1016/j.parkreldis.2020.10.003 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.parkreldis.2020.10.003 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1353802020307781 
|
| Author Notes: | Mariana Moscovich, Sebastian Heinzel, Ronald B. Postuma, Ralf Reilmann, Thomas Klockgether, Heike Jacobi, Günter Höglinger, Daniela Berg |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1748089412 | ||
| 003 | DE-627 | ||
| 005 | 20230426072714.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210211s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.parkreldis.2020.10.003 |2 doi | |
| 035 | |a (DE-627)1748089412 | ||
| 035 | |a (DE-599)KXP1748089412 | ||
| 035 | |a (OCoLC)1341392421 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Moscovich, Mariana |e VerfasserIn |0 (DE-588)1226991173 |0 (DE-627)1748091395 |4 aut | |
| 245 | 1 | 0 | |a How specific are non-motor symptoms in the prodrome of Parkinson's disease compared to other movement disorders? |c Mariana Moscovich, Sebastian Heinzel, Ronald B. Postuma, Ralf Reilmann, Thomas Klockgether, Heike Jacobi, Günter Höglinger, Daniela Berg |
| 264 | 1 | |c 5 October 2020 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.02.2021 | ||
| 520 | |a The clinical diagnosis of Parkinson's disease (PD) based on motor signs is often preceded by several non-motor symptoms that can indicate early prodromal neurodegenerative processes. Such prodromal symptoms can aid the early detection of PD, but their specificity for prodromal PD in comparison to prodromes of other movement disorders is still largely unclear. We here aim to give a first insight into the published evidence of prodromal non-motor symptoms in PD, dementia with Lewy bodies (DLB), multiple system atrophy (MSA), Huntington's disease (HD), progressive supranuclear palsy (PSP) and spinocerebellar ataxia (SCA). REM-sleep behavior disorder (RBD) and autonomic dysfunction have been observed in the prodromes of PD, MSA, DLB and SCA. Depression and cognitive decline have been reported for prodromal PD, DLB, HD, SCA, and PSP. Olfactory loss has only been described in prodromal PD/DLB. However, estimating the specificity of prodromal non-motor symptoms in PD is so far complicated by scarce prospective evidence and study limitations. Information on marker specificity is a prerequisite for an accurate early (differential) diagnosis of prodromal diseases, as well as specific recruitment for targeted neuroprotective interventions. We here would like to raise awareness of these issues and encourage further prospective research of prodromal non-motor symptoms in neurodegenerative movement disorders and other diseases. | ||
| 650 | 4 | |a Marker | |
| 650 | 4 | |a Neurodegeneration | |
| 650 | 4 | |a Non-motor | |
| 650 | 4 | |a Presymptomatic | |
| 650 | 4 | |a Prodromal | |
| 700 | 1 | |a Heinzel, Sebastian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Postuma, Ronald B. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Reilmann, Ralf |e VerfasserIn |4 aut | |
| 700 | 1 | |a Klockgether, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jacobi, Heike |e VerfasserIn |0 (DE-588)1163027812 |0 (DE-627)1027272150 |0 (DE-576)507747666 |4 aut | |
| 700 | 1 | |a Höglinger, Günter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Berg, Daniela |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Parkinsonism & related disorders |d Amsterdam [u.a.] : Elsevier Science, 1995 |g 81(2020), Seite 213-218 |h Online-Ressource |w (DE-627)32448898X |w (DE-600)2027635-7 |w (DE-576)272349704 |x 1873-5126 |7 nnas |a How specific are non-motor symptoms in the prodrome of Parkinson's disease compared to other movement disorders? |
| 773 | 1 | 8 | |g volume:81 |g year:2020 |g pages:213-218 |g extent:6 |a How specific are non-motor symptoms in the prodrome of Parkinson's disease compared to other movement disorders? |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.parkreldis.2020.10.003 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1353802020307781 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210211 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1163027812 |a Jacobi, Heike |m 1163027812:Jacobi, Heike |d 910000 |d 911100 |d 50000 |e 910000PJ1163027812 |e 911100PJ1163027812 |e 50000PJ1163027812 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 6 | ||
| 999 | |a KXP-PPN1748089412 |e 3851328086 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"recId":"32448898X","origin":[{"publisher":"Elsevier Science","dateIssuedDisp":"1995-","dateIssuedKey":"1995","publisherPlace":"Amsterdam [u.a.]"}],"title":[{"subtitle":"official journal of the World Federation of Neurology Research Committee on Parkinsonism and Related Disorders","title":"Parkinsonism & related disorders","title_sort":"Parkinsonism & related disorders"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2027635-7"],"eki":["32448898X"],"issn":["1873-5126"]},"note":["Gesehen am 10.02.06","Ungezählte Beil.: Supplement"],"pubHistory":["1.1995 -"],"language":["eng"],"part":{"text":"81(2020), Seite 213-218","extent":"6","pages":"213-218","volume":"81","year":"2020"},"titleAlt":[{"title":"Parkinsonism and related disorders"}],"disp":"How specific are non-motor symptoms in the prodrome of Parkinson's disease compared to other movement disorders?Parkinsonism & related disorders","type":{"media":"Online-Ressource","bibl":"periodical"}}],"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"5 October 2020"}],"title":[{"title":"How specific are non-motor symptoms in the prodrome of Parkinson's disease compared to other movement disorders?","title_sort":"How specific are non-motor symptoms in the prodrome of Parkinson's disease compared to other movement disorders?"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"6 S."}],"id":{"doi":["10.1016/j.parkreldis.2020.10.003"],"eki":["1748089412"]},"recId":"1748089412","person":[{"family":"Moscovich","role":"aut","given":"Mariana","display":"Moscovich, Mariana"},{"display":"Heinzel, Sebastian","given":"Sebastian","family":"Heinzel","role":"aut"},{"family":"Postuma","role":"aut","display":"Postuma, Ronald B.","given":"Ronald B."},{"display":"Reilmann, Ralf","given":"Ralf","role":"aut","family":"Reilmann"},{"role":"aut","family":"Klockgether","given":"Thomas","display":"Klockgether, Thomas"},{"role":"aut","family":"Jacobi","display":"Jacobi, Heike","given":"Heike"},{"role":"aut","family":"Höglinger","given":"Günter","display":"Höglinger, Günter"},{"role":"aut","family":"Berg","given":"Daniela","display":"Berg, Daniela"}],"note":["Gesehen am 11.02.2021"],"language":["eng"],"name":{"displayForm":["Mariana Moscovich, Sebastian Heinzel, Ronald B. Postuma, Ralf Reilmann, Thomas Klockgether, Heike Jacobi, Günter Höglinger, Daniela Berg"]}} | ||
| SRT | |a MOSCOVICHMHOWSPECIFI5202 | ||