Optimal adaptive two-stage designs for phase II cancer clinical trials
In oncology, single-arm two-stage designs with binary endpoint are widely applied in phase II for the development of cytotoxic cancer therapies. Simon's optimal design with prefixed sample sizes in both stages minimizes the expected sample size under the null hypothesis and is one of the most p...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19 July 2013
|
| In: |
Biometrical journal
Year: 2013, Jahrgang: 55, Heft: 6, Pages: 955-968 |
| ISSN: | 1521-4036 |
| DOI: | 10.1002/bimj.201200220 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/bimj.201200220
|
| Verfasserangaben: | Stefan Englert and Meinhard Kieser |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1748191748 | ||
| 003 | DE-627 | ||
| 005 | 20220819104444.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210212s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/bimj.201200220 |2 doi | |
| 035 | |a (DE-627)1748191748 | ||
| 035 | |a (DE-599)KXP1748191748 | ||
| 035 | |a (OCoLC)1341392990 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Englert, Stefan |d 1986- |e VerfasserIn |0 (DE-588)1037466241 |0 (DE-627)755789539 |0 (DE-576)391501917 |4 aut | |
| 245 | 1 | 0 | |a Optimal adaptive two-stage designs for phase II cancer clinical trials |c Stefan Englert and Meinhard Kieser |
| 264 | 1 | |c 19 July 2013 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.02.2021 | ||
| 520 | |a In oncology, single-arm two-stage designs with binary endpoint are widely applied in phase II for the development of cytotoxic cancer therapies. Simon's optimal design with prefixed sample sizes in both stages minimizes the expected sample size under the null hypothesis and is one of the most popular designs. The search algorithms that are currently used to identify phase II designs showing prespecified characteristics are computationally intensive. For this reason, most authors impose restrictions on their search procedure. However, it remains unclear to what extent this approach influences the optimality of the resulting designs. This article describes an extension to fixed sample size phase II designs by allowing the sample size of stage two to depend on the number of responses observed in the first stage. Furthermore, we present a more efficient numerical algorithm that allows for an exhaustive search of designs. Comparisons between designs presented in the literature and the proposed optimal adaptive designs show that while the improvements are generally moderate, notable reductions in the average sample size can be achieved for specific parameter constellations when applying the new method and search strategy. | ||
| 650 | 4 | |a Adaptive design | |
| 650 | 4 | |a Algorithms | |
| 650 | 4 | |a Biometry | |
| 650 | 4 | |a Branch-and-bound algorithm | |
| 650 | 4 | |a Clinical Trials, Phase II as Topic | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Neoplasms | |
| 650 | 4 | |a Phase II clinical trial | |
| 650 | 4 | |a Sample size | |
| 650 | 4 | |a Sample Size | |
| 650 | 4 | |a Treatment Outcome | |
| 650 | 4 | |a Two-stage design | |
| 700 | 1 | |a Kieser, Meinhard |d 1960- |e VerfasserIn |0 (DE-588)103276547X |0 (DE-627)739277766 |0 (DE-576)168963825 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biometrical journal |d Berlin : Wiley-VCH, 1977 |g 55(2013), 6, Seite 955-968 |h Online-Ressource |w (DE-627)271350229 |w (DE-600)1479920-0 |w (DE-576)078590868 |x 1521-4036 |7 nnas |a Optimal adaptive two-stage designs for phase II cancer clinical trials |
| 773 | 1 | 8 | |g volume:55 |g year:2013 |g number:6 |g pages:955-968 |g extent:14 |a Optimal adaptive two-stage designs for phase II cancer clinical trials |
| 856 | 4 | 0 | |u https://doi.org/10.1002/bimj.201200220 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210212 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 103276547X |a Kieser, Meinhard |m 103276547X:Kieser, Meinhard |d 910000 |d 999701 |e 910000PK103276547X |e 999701PK103276547X |k 0/910000/ |k 1/910000/999701/ |p 2 |y j | ||
| 998 | |g 1037466241 |a Englert, Stefan |m 1037466241:Englert, Stefan |d 50000 |e 50000PE1037466241 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1748191748 |e 3851658345 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 12.02.2021"],"origin":[{"dateIssuedDisp":"19 July 2013","dateIssuedKey":"2013"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"Optimal adaptive two-stage designs for phase II cancer clinical trials","title_sort":"Optimal adaptive two-stage designs for phase II cancer clinical trials"}],"person":[{"given":"Stefan","family":"Englert","display":"Englert, Stefan","role":"aut"},{"role":"aut","display":"Kieser, Meinhard","family":"Kieser","given":"Meinhard"}],"language":["eng"],"physDesc":[{"extent":"14 S."}],"relHost":[{"note":["Gesehen am 17.04.07"],"title":[{"title_sort":"Biometrical journal","title":"Biometrical journal"}],"pubHistory":["Volume 19, issue 1 (1977)-"],"origin":[{"dateIssuedKey":"1977","publisher":"Wiley-VCH","dateIssuedDisp":"1977-","publisherPlace":"Berlin"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Optimal adaptive two-stage designs for phase II cancer clinical trialsBiometrical journal","physDesc":[{"extent":"Online-Ressource"}],"part":{"extent":"14","pages":"955-968","volume":"55","text":"55(2013), 6, Seite 955-968","issue":"6","year":"2013"},"language":["eng","ger"],"id":{"doi":["10.1002/(ISSN)1521-4036"],"issn":["1521-4036"],"zdb":["1479920-0"],"eki":["271350229"]},"recId":"271350229"}],"name":{"displayForm":["Stefan Englert and Meinhard Kieser"]},"id":{"eki":["1748191748"],"doi":["10.1002/bimj.201200220"]},"recId":"1748191748"} | ||
| SRT | |a ENGLERTSTEOPTIMALADA1920 | ||