Effective infection, apoptotic cell killing and gene transfer of human hepatoma cells but not primary hepatocytes by parvovirus H1 and derived vectors

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Autonomous parvoviruses preferentially replicate in and kill in vitro-transformed cells and reduce the incidence of spontaneous and implanted tumors in animals. Because of these natural oncotropic and oncolytic properties, parvoviruses deserve to be considered as potential antitumor vectors. Here, w...

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Bibliographic Details
Main Authors:	Möhler, Markus (Author) , Stremmel, Wolfgang (Author) , Rommelaere, Jean (Author)
Format:	Article (Journal)
Language:	English
Published:	02 May 2001
In:	Cancer gene therapy Year: 2001, Volume: 8, Issue: 3, Pages: 158-167
ISSN:	1476-5500
DOI:	10.1038/sj.cgt.7700288
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.cgt.7700288 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/7700288
Author Notes:	Markus Moehler, Boris Blechacz, Nancy Weiskopf, Maja Zeidler, Wolfgang Stremmel, Jean Rommelaere, Peter R. Galle, and Jan J. Cornelis

Parvovirus H1 selectively induces cytotoxic effects on human neuroblastoma cells by Lacroix, Jeannine (Author) , Leuchs, Barbara (Author) , Li, Junwei (Author) , Hristov, Georgi (Author) , Deubzer, Hedwig E. (Author) , Kulozik, Andreas (Author) , Rommelaere, Jean (Author) , Schlehofer, Jörg R. (Author) , Witt, Olaf (Author) ,

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Expression profiling of human hepatoma cells reveals global repression of genes involved in cell proliferation, growth, and apoptosis upon infection with parvovirus H-1 by Li, Jianhong (Author) , Rommelaere, Jean (Author) ,

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Parvovirus H-1 infection of human glioma cells leads to complete viral replication and efficient cell killing by Herrero y Calle, Marta (Author) , Herold-Mende, Christel (Author) , Rommelaere, Jean (Author) , Schlehofer, Jörg R. (Author) , Geletneky, Karsten (Author) ,

in: International journal of cancer, 109 (2004), 1, Seite 76-84

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Chimeric and pseudotyped parvoviruses minimize the contamination of recombinant stocks with replication-competent viruses and Iidentify a DNA sequence that restricts parvovirus H-1... by Wrzesinski, Claudia (Author) , Salomé, Nathalie (Author) , Rommelaere, Jean (Author) , Dinsart, Christiane (Author) ,

in: Journal of virology, 77 (2003), 6, Seite 3851-3858

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Novel PKCη is required to activate replicative functions of the major nonstructural protein NS1 of minute virus of mice by Lachmann, Sylvie (Author) , Rommelaere, Jean (Author) , Nüesch, Jürg P. F. (Author) ,

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Oncolytic parvovirus H1 induces release of heat-shock protein HSP72 in susceptible human tumor cells but may not affect primary immune cells by Möhler, Markus (Author) , Rommelaere, Jean (Author) ,

in: Cancer gene therapy, 10 (2003), 6, Seite 477-480

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Production of recombinant H1 parvovirus stocks devoid of replication-competent viruses by Brown, Caroline S. (Author) , Rommelaere, Jean (Author) , Dinsart, Christiane (Author) ,

in: Human gene therapy, 13 (2002), 18, Seite 2135-2145

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Regulation of MVM NS1 by protein kinase C: Impact of mutagenesis at consensus phosphorylation sites on replicative functions and cytopathic effects by Corbau, Romuald (Author) , Rommelaere, Jean (Author) , Nüesch, Jürg P. F. (Author) ,

in: Virology, 278 (2000), 1, Seite 151-167

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Inhibition of transcription-regulating properties of nonstructural protein 1 (NS1) of parvovirus minute virus of mice by a dominant-negative mutant form of NS1 by Deleu, Laurent (Author) , Nüesch, Jürg P. F. (Author) , Rommelaere, Jean (Author) ,

in: Journal of general virology, 82 (2001), 8, Seite 1929-1934

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Experimentally induced infection with autonomous parvoviruses, minute virus of mice and H-1, in the african multimammate mouse (Mastomys coucha) by Haag, Andreas (Author) , Rommelaere, Jean (Author) ,

in: Comparative medicine, 50 (2000), 6, Seite 613-621

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H-1 parvovirus-associated replication bodies: a distinct virus-induced nuclear structure by Cziepluch, Celina (Author) , Lichter, Peter (Author) , Rommelaere, Jean (Author) ,

in: Journal of virology, 74 (2000), 10, Seite 4807-4815

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DNA unwinding functions of minute virus of mice NS1 protein are modulated specifically by the lambda isoform of protein kinase C by Dettwiler, Sabine (Author) , Rommelaere, Jean (Author) , Nüesch, Jürg P. F. (Author) ,

in: Journal of virology, 73 (1999), 9, Seite 7410-7420

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Parvovirus H-1-induced cell death: influence of intracellular NAD consumption on the regulation of necrosis and apoptosis by Ran, Zhi-Hua (Author) , Rommelaere, Jean (Author) ,

in: Virus research, 65 (1999), 2, Seite 161-174

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