Effective infection, apoptotic cell killing and gene transfer of human hepatoma cells but not primary hepatocytes by parvovirus H1 and derived vectors

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Autonomous parvoviruses preferentially replicate in and kill in vitro-transformed cells and reduce the incidence of spontaneous and implanted tumors in animals. Because of these natural oncotropic and oncolytic properties, parvoviruses deserve to be considered as potential antitumor vectors. Here, w...

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Bibliographische Detailangaben
Hauptverfasser:	Möhler, Markus (VerfasserIn) , Stremmel, Wolfgang (VerfasserIn) , Rommelaere, Jean (VerfasserIn)
Dokumenttyp:	Article (Journal)
Sprache:	Englisch
Veröffentlicht:	02 May 2001
In:	Cancer gene therapy Year: 2001, Jahrgang: 8, Heft: 3, Pages: 158-167
ISSN:	1476-5500
DOI:	10.1038/sj.cgt.7700288
Online-Zugang:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.cgt.7700288 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/7700288
Verfasserangaben:	Markus Moehler, Boris Blechacz, Nancy Weiskopf, Maja Zeidler, Wolfgang Stremmel, Jean Rommelaere, Peter R. Galle, and Jan J. Cornelis

Parvovirus H1 selectively induces cytotoxic effects on human neuroblastoma cells von Lacroix, Jeannine (VerfasserIn) , Leuchs, Barbara (VerfasserIn) , Li, Junwei (VerfasserIn) , Hristov, Georgi (VerfasserIn) , Deubzer, Hedwig E. (VerfasserIn) , Kulozik, Andreas (VerfasserIn) , Rommelaere, Jean (VerfasserIn) , Schlehofer, Jörg R. (VerfasserIn) , Witt, Olaf (VerfasserIn) ,

in: International journal of cancer, 127 (2010), 5, Seite 1230-1239

Article (Journal) Online Resource

Expression profiling of human hepatoma cells reveals global repression of genes involved in cell proliferation, growth, and apoptosis upon infection with parvovirus H-1 von Li, Jianhong (VerfasserIn) , Rommelaere, Jean (VerfasserIn) ,

in: Journal of virology, 79 (2005), 4, Seite 2274-2286

Article (Journal) Online Resource

Parvovirus H-1 infection of human glioma cells leads to complete viral replication and efficient cell killing von Herrero y Calle, Marta (VerfasserIn) , Herold-Mende, Christel (VerfasserIn) , Rommelaere, Jean (VerfasserIn) , Schlehofer, Jörg R. (VerfasserIn) , Geletneky, Karsten (VerfasserIn) ,

in: International journal of cancer, 109 (2004), 1, Seite 76-84

Article (Journal) Online Resource

Chimeric and pseudotyped parvoviruses minimize the contamination of recombinant stocks with replication-competent viruses and Iidentify a DNA sequence that restricts parvovirus H-1... von Wrzesinski, Claudia (VerfasserIn) , Salomé, Nathalie (VerfasserIn) , Rommelaere, Jean (VerfasserIn) , Dinsart, Christiane (VerfasserIn) ,

in: Journal of virology, 77 (2003), 6, Seite 3851-3858

Article (Journal) Online Resource

Novel PKCη is required to activate replicative functions of the major nonstructural protein NS1 of minute virus of mice von Lachmann, Sylvie (VerfasserIn) , Rommelaere, Jean (VerfasserIn) , Nüesch, Jürg P. F. (VerfasserIn) ,

in: Journal of virology, 77 (2003), 14, Seite 8048-8060

Article (Journal) Online Resource

Oncolytic parvovirus H1 induces release of heat-shock protein HSP72 in susceptible human tumor cells but may not affect primary immune cells von Möhler, Markus (VerfasserIn) , Rommelaere, Jean (VerfasserIn) ,

in: Cancer gene therapy, 10 (2003), 6, Seite 477-480

Article (Journal) Online Resource

Production of recombinant H1 parvovirus stocks devoid of replication-competent viruses von Brown, Caroline S. (VerfasserIn) , Rommelaere, Jean (VerfasserIn) , Dinsart, Christiane (VerfasserIn) ,

in: Human gene therapy, 13 (2002), 18, Seite 2135-2145

Article (Journal) Online Resource

Regulation of MVM NS1 by protein kinase C: Impact of mutagenesis at consensus phosphorylation sites on replicative functions and cytopathic effects von Corbau, Romuald (VerfasserIn) , Rommelaere, Jean (VerfasserIn) , Nüesch, Jürg P. F. (VerfasserIn) ,

in: Virology, 278 (2000), 1, Seite 151-167

Article (Journal) Online Resource

Inhibition of transcription-regulating properties of nonstructural protein 1 (NS1) of parvovirus minute virus of mice by a dominant-negative mutant form of NS1 von Deleu, Laurent (VerfasserIn) , Nüesch, Jürg P. F. (VerfasserIn) , Rommelaere, Jean (VerfasserIn) ,

in: Journal of general virology, 82 (2001), 8, Seite 1929-1934

Article (Journal) Online Resource

Experimentally induced infection with autonomous parvoviruses, minute virus of mice and H-1, in the african multimammate mouse (Mastomys coucha) von Haag, Andreas (VerfasserIn) , Rommelaere, Jean (VerfasserIn) ,

in: Comparative medicine, 50 (2000), 6, Seite 613-621

Verlag, lizenzpflichtig, Volltext

Article (Journal) Online Resource

H-1 parvovirus-associated replication bodies: a distinct virus-induced nuclear structure von Cziepluch, Celina (VerfasserIn) , Lichter, Peter (VerfasserIn) , Rommelaere, Jean (VerfasserIn) ,

in: Journal of virology, 74 (2000), 10, Seite 4807-4815

Article (Journal) Online Resource

DNA unwinding functions of minute virus of mice NS1 protein are modulated specifically by the lambda isoform of protein kinase C von Dettwiler, Sabine (VerfasserIn) , Rommelaere, Jean (VerfasserIn) , Nüesch, Jürg P. F. (VerfasserIn) ,

in: Journal of virology, 73 (1999), 9, Seite 7410-7420

Article (Journal) Online Resource

Parvovirus H-1-induced cell death: influence of intracellular NAD consumption on the regulation of necrosis and apoptosis von Ran, Zhi-Hua (VerfasserIn) , Rommelaere, Jean (VerfasserIn) ,

in: Virus research, 65 (1999), 2, Seite 161-174

Article (Journal) Online Resource