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In vivo accumulation of cyclin A and cellular replication factors in autonomous parvovirus minute virus of mice-associated replication bodies

Autonomous parvovirus minute virus of mice (MVM) DNA replication is strictly dependent on cellular factors expressed during the S phase of the cell cycle. Here we report that MVM DNA replication proceeds in specific nuclear structures termed autonomous parvovirus-associated replication bodies, where...

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Bibliographic Details
Main Authors: Bashir, Tarig (Author) , Rommelaere, Jean (Author) , Cziepluch, Celina (Author)
Format: Article (Journal)
Language:English
Published: May 1, 2001
In: Journal of virology
Year: 2001, Volume: 75, Issue: 9, Pages: 4394-4398
ISSN:1098-5514
DOI:10.1128/JVI.75.9.4394-4398.2001
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1128/JVI.75.9.4394-4398.2001
Verlag, lizenzpflichtig, Volltext: https://jvi.asm.org/content/75/9/4394
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Author Notes:Tarig Bashir, Jean Rommelaere, and Celina Cziepluch
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Summary:Autonomous parvovirus minute virus of mice (MVM) DNA replication is strictly dependent on cellular factors expressed during the S phase of the cell cycle. Here we report that MVM DNA replication proceeds in specific nuclear structures termed autonomous parvovirus-associated replication bodies, where components of the basic cellular replication machinery accumulate. The presence of DNA polymerases α and δ in these bodies suggests that MVM utilizes partially preformed cellular replication complexes for its replication. The recruitment of cyclin A points to a role for this cell cycle factor in MVM DNA replication beyond its involvement in activating the conversion of virion single-stranded DNA to the duplex replicative form.
Item Description:Gesehen am 15.02.2021
Physical Description:Online Resource
ISSN:1098-5514
DOI:10.1128/JVI.75.9.4394-4398.2001

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