Inhibition of transcription-regulating properties of nonstructural protein 1 (NS1) of parvovirus minute virus of mice by a dominant-negative mutant form of NS1
Nonstructural protein 1 (NS1) of minute virus of mice is involved in viral DNA replication, transcriptional regulation and cytotoxic action in the host cell. Viral DNA replication is dependent on the ability of NS1 to form homo-oligomers. To investigate whether oligomerization is required for NS1 tr...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 August 2001
|
| In: |
Journal of general virology
Year: 2001, Jahrgang: 82, Heft: 8, Pages: 1929-1934 |
| ISSN: | 1465-2099 |
| DOI: | 10.1099/0022-1317-82-8-1929 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1099/0022-1317-82-8-1929 Verlag, lizenzpflichtig, Volltext: https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-82-8-1929 
|
| Verfasserangaben: | Laurent Deleu, Aurora Pujol, Jürg P.F. Nüesch and Jean Rommelaere |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1748302892 | ||
| 003 | DE-627 | ||
| 005 | 20220819105524.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210215s2001 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1099/0022-1317-82-8-1929 |2 doi | |
| 035 | |a (DE-627)1748302892 | ||
| 035 | |a (DE-599)KXP1748302892 | ||
| 035 | |a (OCoLC)1341393294 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Deleu, Laurent |e VerfasserIn |0 (DE-588)1227248318 |0 (DE-627)1748303279 |4 aut | |
| 245 | 1 | 0 | |a Inhibition of transcription-regulating properties of nonstructural protein 1 (NS1) of parvovirus minute virus of mice by a dominant-negative mutant form of NS1 |c Laurent Deleu, Aurora Pujol, Jürg P.F. Nüesch and Jean Rommelaere |
| 246 | 3 | 0 | |a one |
| 264 | 1 | |c 01 August 2001 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.02.2021 | ||
| 520 | |a Nonstructural protein 1 (NS1) of minute virus of mice is involved in viral DNA replication, transcriptional regulation and cytotoxic action in the host cell. Viral DNA replication is dependent on the ability of NS1 to form homo-oligomers. To investigate whether oligomerization is required for NS1 transcriptional activities, a functionally impaired mutant derivative of NS1 that was able to interact with the wild-type (wt) protein and inhibit its activity in a dominant-negative manner was designed. This mutant provided evidence that transactivation of the parvoviral P38 promoter and transinhibition of a heterologous promoter by NS1 were both affected by the co-expression of the wt and the dominant-negative mutant form of NS1. These results indicate that additional functions of NS1, involved in promoter regulation, require oligomer formation., | ||
| 700 | 1 | |a Nüesch, Jürg P. F. |e VerfasserIn |0 (DE-588)122699444X |0 (DE-627)174809307X |4 aut | |
| 700 | 1 | |a Rommelaere, Jean |d 1948- |e VerfasserIn |0 (DE-588)1201673909 |0 (DE-627)1685754767 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of general virology |d Reading : Soc., 1967 |g 82(2001), 8, Seite 1929-1934 |h Online-Ressource |w (DE-627)316018058 |w (DE-600)2007065-2 |w (DE-576)090954734 |x 1465-2099 |7 nnas |a Inhibition of transcription-regulating properties of nonstructural protein 1 (NS1) of parvovirus minute virus of mice by a dominant-negative mutant form of NS1 |
| 773 | 1 | 8 | |g volume:82 |g year:2001 |g number:8 |g pages:1929-1934 |g extent:6 |a Inhibition of transcription-regulating properties of nonstructural protein 1 (NS1) of parvovirus minute virus of mice by a dominant-negative mutant form of NS1 |
| 856 | 4 | 0 | |u https://doi.org/10.1099/0022-1317-82-8-1929 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-82-8-1929 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210215 | ||
| 993 | |a Article | ||
| 994 | |a 2001 | ||
| 998 | |g 1201673909 |a Rommelaere, Jean |m 1201673909:Rommelaere, Jean |d 50000 |e 50000PR1201673909 |k 0/50000/ |p 4 |y j | ||
| 998 | |g 122699444X |a Nüesch, Jürg P. F. |m 122699444X:Nüesch, Jürg P. F. |d 50000 |e 50000PN122699444X |k 0/50000/ |p 3 | ||
| 999 | |a KXP-PPN1748302892 |e 3853726798 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Inhibition of transcription-regulating properties of nonstructural protein 1 (NS1) of parvovirus minute virus of mice by a dominant-negative mutant form of NS1","title_sort":"Inhibition of transcription-regulating properties of nonstructural protein 1 (NS1) of parvovirus minute virus of mice by a dominant-negative mutant form of NS1"}],"person":[{"family":"Deleu","given":"Laurent","roleDisplay":"VerfasserIn","display":"Deleu, Laurent","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Nüesch, Jürg P. F.","given":"Jürg P. F.","family":"Nüesch"},{"given":"Jean","family":"Rommelaere","role":"aut","display":"Rommelaere, Jean","roleDisplay":"VerfasserIn"}],"language":["eng"],"recId":"1748302892","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 15.02.2021"],"id":{"doi":["10.1099/0022-1317-82-8-1929"],"eki":["1748302892"]},"origin":[{"dateIssuedDisp":"01 August 2001","dateIssuedKey":"2001"}],"name":{"displayForm":["Laurent Deleu, Aurora Pujol, Jürg P.F. Nüesch and Jean Rommelaere"]},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["Society for General Microbiology"]},"id":{"zdb":["2007065-2"],"eki":["316018058"],"issn":["1465-2099"]},"origin":[{"dateIssuedDisp":"1967-","dateIssuedKey":"1967","publisher":"Soc.","publisherPlace":"Reading"}],"recId":"316018058","language":["eng"],"corporate":[{"role":"isb","roleDisplay":"Herausgebendes Organ","display":"Society for General Microbiology"}],"disp":"Inhibition of transcription-regulating properties of nonstructural protein 1 (NS1) of parvovirus minute virus of mice by a dominant-negative mutant form of NS1Journal of general virology","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Titelzusatz ab 77.1996","Gesehen am 26.03.25"],"titleAlt":[{"title":"JGV"}],"part":{"extent":"6","text":"82(2001), 8, Seite 1929-1934","volume":"82","issue":"8","pages":"1929-1934","year":"2001"},"pubHistory":["1.1967 -"],"title":[{"title_sort":"Journal of general virology","subtitle":"JGV","title":"Journal of general virology"}]}],"physDesc":[{"extent":"6 S."}]} | ||
| SRT | |a DELEULAUREINHIBITION0120 | ||