AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion
The infiltrative nature of Glioblastoma (GBM), the most aggressive primary brain tumor, critically prevents complete surgical resection and masks tumor cells behind the blood brain barrier reducing the efficacy of systemic treatment. Here, we use a genome-wide interference screen to determine invasi...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 December 2020
|
| In: |
Nature Communications
Year: 2020, Jahrgang: 11, Pages: 1-16 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-20029-y |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-020-20029-y Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-020-20029-y 
|
| Verfasserangaben: | Anne Schuster, Eliane Klein, Virginie Neirinckx, Arnon Møldrup Knudsen, Carina Fabian, Ann-Christin Hau, Monika Dieterle, Anais Oudin, Petr V. Nazarov, Anna Golebiewska, Arnaud Muller, Daniel Perez-Hernandez, Sophie Rodius, Gunnar Dittmar, Rolf Bjerkvig, Christel Herold-Mende, Barbara Klink, Bjarne Winther Kristensen & Simone P. Niclou |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1748432842 | ||
| 003 | DE-627 | ||
| 005 | 20250414234803.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210216s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-020-20029-y |2 doi | |
| 035 | |a (DE-627)1748432842 | ||
| 035 | |a (DE-599)KXP1748432842 | ||
| 035 | |a (OCoLC)1341393385 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schuster, Anne |e VerfasserIn |0 (DE-588)1227399693 |0 (DE-627)1748442511 |4 aut | |
| 245 | 1 | 0 | |a AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion |c Anne Schuster, Eliane Klein, Virginie Neirinckx, Arnon Møldrup Knudsen, Carina Fabian, Ann-Christin Hau, Monika Dieterle, Anais Oudin, Petr V. Nazarov, Anna Golebiewska, Arnaud Muller, Daniel Perez-Hernandez, Sophie Rodius, Gunnar Dittmar, Rolf Bjerkvig, Christel Herold-Mende, Barbara Klink, Bjarne Winther Kristensen & Simone P. Niclou |
| 264 | 1 | |c 11 December 2020 | |
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 16.02.2021 | ||
| 520 | |a The infiltrative nature of Glioblastoma (GBM), the most aggressive primary brain tumor, critically prevents complete surgical resection and masks tumor cells behind the blood brain barrier reducing the efficacy of systemic treatment. Here, we use a genome-wide interference screen to determine invasion-essential genes and identify the AN1/A20 zinc finger domain containing protein 3 (ZFAND3) as a crucial driver of GBM invasion. Using patient-derived cellular models, we show that loss of ZFAND3 hampers the invasive capacity of GBM, whereas ZFAND3 overexpression increases motility in cells that were initially not invasive. At the mechanistic level, we find that ZFAND3 activity requires nuclear localization and integral zinc-finger domains. Our findings indicate that ZFAND3 acts within a nuclear protein complex to activate gene transcription and regulates the promoter of invasion-related genes such as COL6A2, FN1, and NRCAM. Further investigation in ZFAND3 function in GBM and other invasive cancers is warranted. | ||
| 700 | 1 | |a Klein, Eliane |e VerfasserIn |4 aut | |
| 700 | 1 | |a Neirinckx, Virginie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Knudsen, Arnon Møldrup |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fabian, Carina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hau, Ann-Christin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dieterle, Monika |e VerfasserIn |4 aut | |
| 700 | 1 | |a Oudin, Anais |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nazarov, Petr V. |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Golebiewska, Anna |e VerfasserIn |0 (DE-588)1360244581 |0 (DE-627)1919929614 |4 aut | |
| 700 | 1 | |a Muller, Arnaud |e VerfasserIn |4 aut | |
| 700 | 1 | |a Perez-Hernandez, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rodius, Sophie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dittmar, Gunnar |d 1967- |e VerfasserIn |0 (DE-588)115587918 |0 (DE-627)691433461 |0 (DE-576)28996461X |4 aut | |
| 700 | 1 | |a Bjerkvig, Rolf |e VerfasserIn |4 aut | |
| 700 | 1 | |a Herold-Mende, Christel |e VerfasserIn |0 (DE-588)1022936549 |0 (DE-627)717335577 |0 (DE-576)366194267 |4 aut | |
| 700 | 1 | |a Klink, Barbara |d 1978- |e VerfasserIn |0 (DE-588)135753716 |0 (DE-627)570587409 |0 (DE-576)300628293 |4 aut | |
| 700 | 1 | |a Kristensen, Bjarne Winther |e VerfasserIn |0 (DE-588)1071333542 |0 (DE-627)825706424 |0 (DE-576)433019700 |4 aut | |
| 700 | 1 | |8 2\p |a Niclou, Simone |e VerfasserIn |0 (DE-588)1275965202 |0 (DE-627)1909761044 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature Communications |d [London] : Springer Nature, 2010 |g 11(2020), Artikel-ID 6366, Seite 1-16 |h Online-Ressource |w (DE-627)626457688 |w (DE-600)2553671-0 |w (DE-576)331555905 |x 2041-1723 |7 nnas |a AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion |
| 773 | 1 | 8 | |g volume:11 |g year:2020 |g elocationid:6366 |g pages:1-16 |g extent:16 |a AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41467-020-20029-y |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41467-020-20029-y |x Verlag |z lizenzpflichtig |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20250403 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20250301 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20210216 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1022936549 |a Herold-Mende, Christel |m 1022936549:Herold-Mende, Christel |d 910000 |d 911200 |e 910000PH1022936549 |e 911200PH1022936549 |k 0/910000/ |k 1/910000/911200/ |p 16 | ||
| 999 | |a KXP-PPN1748432842 |e 3855464898 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion","title_sort":"AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion"}],"physDesc":[{"extent":"16 S."}],"relHost":[{"part":{"year":"2020","text":"11(2020), Artikel-ID 6366, Seite 1-16","pages":"1-16","volume":"11","extent":"16"},"title":[{"title":"Nature Communications","title_sort":"Nature Communications"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisher":"Springer Nature ; Nature Publishing Group UK","dateIssuedDisp":"[2010]-","publisherPlace":"[London] ; [London]"}],"disp":"AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasionNature Communications","type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"626457688","id":{"issn":["2041-1723"],"zdb":["2553671-0"],"eki":["626457688"]},"language":["eng"],"pubHistory":["2010-"],"note":["Gesehen am 13.06.24"]}],"person":[{"role":"aut","family":"Schuster","display":"Schuster, Anne","given":"Anne"},{"given":"Eliane","family":"Klein","role":"aut","display":"Klein, Eliane"},{"role":"aut","family":"Neirinckx","display":"Neirinckx, Virginie","given":"Virginie"},{"display":"Knudsen, Arnon Møldrup","role":"aut","family":"Knudsen","given":"Arnon Møldrup"},{"role":"aut","family":"Fabian","display":"Fabian, Carina","given":"Carina"},{"display":"Hau, Ann-Christin","role":"aut","family":"Hau","given":"Ann-Christin"},{"display":"Dieterle, Monika","family":"Dieterle","role":"aut","given":"Monika"},{"family":"Oudin","role":"aut","display":"Oudin, Anais","given":"Anais"},{"display":"Nazarov, Petr V.","role":"aut","family":"Nazarov","given":"Petr V."},{"given":"Anna","role":"aut","family":"Golebiewska","display":"Golebiewska, Anna"},{"role":"aut","family":"Muller","display":"Muller, Arnaud","given":"Arnaud"},{"given":"Daniel","display":"Perez-Hernandez, Daniel","role":"aut","family":"Perez-Hernandez"},{"given":"Sophie","display":"Rodius, Sophie","family":"Rodius","role":"aut"},{"display":"Dittmar, Gunnar","role":"aut","family":"Dittmar","given":"Gunnar"},{"given":"Rolf","family":"Bjerkvig","role":"aut","display":"Bjerkvig, Rolf"},{"display":"Herold-Mende, Christel","role":"aut","family":"Herold-Mende","given":"Christel"},{"given":"Barbara","display":"Klink, Barbara","role":"aut","family":"Klink"},{"family":"Kristensen","role":"aut","display":"Kristensen, Bjarne Winther","given":"Bjarne Winther"},{"display":"Niclou, Simone","role":"aut","family":"Niclou","given":"Simone"}],"language":["eng"],"note":["Gesehen am 16.02.2021"],"origin":[{"dateIssuedDisp":"11 December 2020","dateIssuedKey":"2020"}],"name":{"displayForm":["Anne Schuster, Eliane Klein, Virginie Neirinckx, Arnon Møldrup Knudsen, Carina Fabian, Ann-Christin Hau, Monika Dieterle, Anais Oudin, Petr V. Nazarov, Anna Golebiewska, Arnaud Muller, Daniel Perez-Hernandez, Sophie Rodius, Gunnar Dittmar, Rolf Bjerkvig, Christel Herold-Mende, Barbara Klink, Bjarne Winther Kristensen & Simone P. Niclou"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.1038/s41467-020-20029-y"],"eki":["1748432842"]},"recId":"1748432842"} | ||
| SRT | |a SCHUSTERANAN1TYPEZIN1120 | ||