Clinical translation in the virtual liver network
The liver is the central detoxifying organ, continuously removing xenobiotics from the vascular system. Given its role in drug metabolism, a functional understanding of liver physiology is crucial to optimizing drug efficacy and patient safety. The Virtual Liver Network (VLN), a German national flag...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
30 July 2014
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| In: |
CPT: pharmacometrics & systems pharmacology
Year: 2014, Volume: 3, Issue: 7 |
| ISSN: | 2163-8306 |
| DOI: | https://doi.org/10.1038/psp.2014.25 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1038/psp.2014.25 Verlag, lizenzpflichtig, Volltext: https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1038/psp.2014.25 
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| Author Notes: | L. Kuepfer, R. Kerb and A.M. Henney |
| Summary: | The liver is the central detoxifying organ, continuously removing xenobiotics from the vascular system. Given its role in drug metabolism, a functional understanding of liver physiology is crucial to optimizing drug efficacy and patient safety. The Virtual Liver Network (VLN), a German national flagship research program, focuses on producing validated computer models of human liver physiology. These models are used to analyze patient-derived data and thereby gain mechanistic insights in the processes underlying drug pharmacokinetics (PK). CPT Pharmacometrics Syst. Pharmacol. (2014) 3, e127; doi:10.1038/psp.2014.25; published online 30 July 2014 |
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| Item Description: | Gesehen am 16.02.2021 |
| Physical Description: | Online Resource |
| ISSN: | 2163-8306 |
| DOI: | https://doi.org/10.1038/psp.2014.25 |