Clinical translation in the virtual liver network
The liver is the central detoxifying organ, continuously removing xenobiotics from the vascular system. Given its role in drug metabolism, a functional understanding of liver physiology is crucial to optimizing drug efficacy and patient safety. The Virtual Liver Network (VLN), a German national flag...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 July 2014
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| In: |
CPT: pharmacometrics & systems pharmacology
Year: 2014, Jahrgang: 3, Heft: 7 |
| ISSN: | 2163-8306 |
| DOI: | https://doi.org/10.1038/psp.2014.25 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1038/psp.2014.25 Verlag, lizenzpflichtig, Volltext: https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1038/psp.2014.25 
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| Verfasserangaben: | L. Kuepfer, R. Kerb and A.M. Henney |
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| 520 | |a The liver is the central detoxifying organ, continuously removing xenobiotics from the vascular system. Given its role in drug metabolism, a functional understanding of liver physiology is crucial to optimizing drug efficacy and patient safety. The Virtual Liver Network (VLN), a German national flagship research program, focuses on producing validated computer models of human liver physiology. These models are used to analyze patient-derived data and thereby gain mechanistic insights in the processes underlying drug pharmacokinetics (PK). CPT Pharmacometrics Syst. Pharmacol. (2014) 3, e127; doi:10.1038/psp.2014.25; published online 30 July 2014 | ||
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