Trypanosomatid pin1-type peptidyl-prolyl isomerase is cytosolic and not essential for cell proliferation
Pin1-type peptidyl-prolyl cis/trans isomerases (PPIases) isomerise the peptide bond of specific phosphorylated (Ser/Thr)-Pro residues, regulating various cellular events. Previously, we reported a Pin1-type PPIase in Trypanosoma cruzi, but little is known about its function and subcellular localizat...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2013
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| In: |
The journal of eukaryotic microbiology
Year: 2012, Jahrgang: 60, Heft: 1, Pages: 101-105 |
| ISSN: | 1550-7408 |
| DOI: | https://doi.org/10.1111/jeu.12009 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1111/jeu.12009 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jeu.12009 
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| Verfasserangaben: | Esteban D. Erben, Sheila C. Nardelli, Teresa C.L. de Jesus, Sergio Schenkman & Maria T. Tellez‐Iñon |
MARC
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| 245 | 1 | 0 | |a Trypanosomatid pin1-type peptidyl-prolyl isomerase is cytosolic and not essential for cell proliferation |c Esteban D. Erben, Sheila C. Nardelli, Teresa C.L. de Jesus, Sergio Schenkman & Maria T. Tellez‐Iñon |
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| 520 | |a Pin1-type peptidyl-prolyl cis/trans isomerases (PPIases) isomerise the peptide bond of specific phosphorylated (Ser/Thr)-Pro residues, regulating various cellular events. Previously, we reported a Pin1-type PPIase in Trypanosoma cruzi, but little is known about its function and subcellular localization. Immunofluorescence analysis revealed that in contrast with Pin1-like proteins from diverse organisms, TcPin1 mainly localized in the cytoplasm and was excluded from the nuclei. In addition, RNAi-mediated downregulation of TbPin1 in Trypanosoma brucei did not abolish cell proliferation. Using yeast two-hybrid assay, we identified a MORN domain-containing protein as putative Pin1-binding partners. These data suggest that Pin1-mediated signaling mechanism plays a different role in protozoan parasites. | ||
| 534 | |c 2012 | ||
| 650 | 4 | |a MORN domain | |
| 650 | 4 | |a parvulin | |
| 650 | 4 | |a peptidyl-prolyl isomerase | |
| 650 | 4 | |a Pin1 | |
| 650 | 4 | |a PPIase | |
| 650 | 4 | |a Trypanosoma cruzi | |
| 700 | 1 | |a Nardelli, Sheila C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jesus, Teresa C. L. de |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schenkman, Sergio |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tellez‐Iñon, Maria T. |e VerfasserIn |4 aut | |
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