Plasmacytoid dendritic cells: neglected regulators of the immune response to Staphylococcus aureus
Plasmacytoid dendritic cells (pDC) are a rare subset of leukocytes equipped with Fcgamma and Fcepsilon receptors, which exert contrary effects on sensing of microbial nucleic acids by endosomal Toll-like receptors. In this article we explain how pDC contribute to the immune response to Staphylococcu...
Gespeichert in:
| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 May 2014
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| In: |
Frontiers in immunology
Year: 2014, Jahrgang: 5, Pages: 1-10 |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2014.00238 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fimmu.2014.00238 Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2014.00238/full 
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| Verfasserangaben: | Isabelle Bekeredjian-Ding, Johann Greil, Sandra Ammann and Marijo Parcina |
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| 520 | |a Plasmacytoid dendritic cells (pDC) are a rare subset of leukocytes equipped with Fcgamma and Fcepsilon receptors, which exert contrary effects on sensing of microbial nucleic acids by endosomal Toll-like receptors. In this article we explain how pDC contribute to the immune response to Staphylococcus aureus. Under normal circumstances the pDC participates in the memory response to the pathogen: pDC activation is initiated by uptake of staphylococcal immune complexes with IgG or IgE. However, protein A-expressing S. aureus strains additionally trigger pDC activation in the absence of immunoglobulin. In this context staphylococci exploit the pDC to induce antigen-independent differentiation of IL-10 producing plasmablasts, an elegant means to propagate immune evasion. We further discuss the role of type I interferons in infection with S. aureus and the implications of these findings for the development of immune based therapies and vaccination. | ||
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