Oncolytic parvovirus H1 induces release of heat-shock protein HSP72 in susceptible human tumor cells but may not affect primary immune cells

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Certain autonomous parvoviruses preferentially replicate in and kill in vitro-transformed cells and may reduce the incidence of spontaneous and implanted tumors in animals. Hence, these viruses and their derivatives are currently under evaluation as antitumor vectors. However, the mechanisms underly...

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Bibliographic Details
Main Authors:	Möhler, Markus (Author) , Rommelaere, Jean (Author)
Format:	Article (Journal)
Language:	English
Published:	27 May 2003
In:	Cancer gene therapy Year: 2003, Volume: 10, Issue: 6, Pages: 477-480
ISSN:	1476-5500
DOI:	10.1038/sj.cgt.7700591
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.cgt.7700591 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/7700591
Author Notes:	Markus Moehler, Maja Zeidler, Joerg Schede, Jean Rommelaere, Peter R. Galle, Jan J. Cornelis, and Michael Heike

Parvovirus H1 selectively induces cytotoxic effects on human neuroblastoma cells by Lacroix, Jeannine (Author) , Leuchs, Barbara (Author) , Li, Junwei (Author) , Hristov, Georgi (Author) , Deubzer, Hedwig E. (Author) , Kulozik, Andreas (Author) , Rommelaere, Jean (Author) , Schlehofer, Jörg R. (Author) , Witt, Olaf (Author) ,

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Expression profiling of human hepatoma cells reveals global repression of genes involved in cell proliferation, growth, and apoptosis upon infection with parvovirus H-1 by Li, Jianhong (Author) , Rommelaere, Jean (Author) ,

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Parvovirus H-1 infection of human glioma cells leads to complete viral replication and efficient cell killing by Herrero y Calle, Marta (Author) , Herold-Mende, Christel (Author) , Rommelaere, Jean (Author) , Schlehofer, Jörg R. (Author) , Geletneky, Karsten (Author) ,

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Chimeric and pseudotyped parvoviruses minimize the contamination of recombinant stocks with replication-competent viruses and Iidentify a DNA sequence that restricts parvovirus H-1... by Wrzesinski, Claudia (Author) , Salomé, Nathalie (Author) , Rommelaere, Jean (Author) , Dinsart, Christiane (Author) ,

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Novel PKCη is required to activate replicative functions of the major nonstructural protein NS1 of minute virus of mice by Lachmann, Sylvie (Author) , Rommelaere, Jean (Author) , Nüesch, Jürg P. F. (Author) ,

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Production of recombinant H1 parvovirus stocks devoid of replication-competent viruses by Brown, Caroline S. (Author) , Rommelaere, Jean (Author) , Dinsart, Christiane (Author) ,

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Regulation of MVM NS1 by protein kinase C: Impact of mutagenesis at consensus phosphorylation sites on replicative functions and cytopathic effects by Corbau, Romuald (Author) , Rommelaere, Jean (Author) , Nüesch, Jürg P. F. (Author) ,

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Effective infection, apoptotic cell killing and gene transfer of human hepatoma cells but not primary hepatocytes by parvovirus H1 and derived vectors by Möhler, Markus (Author) , Stremmel, Wolfgang (Author) , Rommelaere, Jean (Author) ,

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Inhibition of transcription-regulating properties of nonstructural protein 1 (NS1) of parvovirus minute virus of mice by a dominant-negative mutant form of NS1 by Deleu, Laurent (Author) , Nüesch, Jürg P. F. (Author) , Rommelaere, Jean (Author) ,

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Experimentally induced infection with autonomous parvoviruses, minute virus of mice and H-1, in the african multimammate mouse (Mastomys coucha) by Haag, Andreas (Author) , Rommelaere, Jean (Author) ,

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H-1 parvovirus-associated replication bodies: a distinct virus-induced nuclear structure by Cziepluch, Celina (Author) , Lichter, Peter (Author) , Rommelaere, Jean (Author) ,

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DNA unwinding functions of minute virus of mice NS1 protein are modulated specifically by the lambda isoform of protein kinase C by Dettwiler, Sabine (Author) , Rommelaere, Jean (Author) , Nüesch, Jürg P. F. (Author) ,

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Parvovirus H-1-induced cell death: influence of intracellular NAD consumption on the regulation of necrosis and apoptosis by Ran, Zhi-Hua (Author) , Rommelaere, Jean (Author) ,

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