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Organotypic co-cultures allow for immortalized human gingival keratinocytes to reconstitute a gingival epithelial phenotype in vitro

We report here that the organotypic co-culture (OCC) system allows for significant preservation of the tissue-specific phenotype of human gingival keratinocytes (IHGK) immortalized with the E6/E7 gene of the human papillomavirus type 16 (HPV16). The approach adopted is based on the OCC system facili...

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Bibliographic Details
Main Authors: Roesch Ely, Mariana (Author) , Steinberg, Thorsten (Author) , Bosch, Franz X. (Author) , Wörtche, Eva (Author) , Whitaker, Noel (Author) , Wiest, Tina (Author) , Kohl, Annette (Author) , Komposch, Gerda (Author) , Tomakidi, Pascal (Author)
Format: Article (Journal)
Language:English
Published: 2006
In: Differentiation
Year: 2006, Volume: 74, Issue: 9, Pages: 622-637
ISSN:1432-0436
DOI:10.1111/j.1432-0436.2006.00099.x
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1432-0436.2006.00099.x
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0301468109602486
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Author Notes:Mariana Roesch-Ely, Thorsten Steinberg, F. Xavier Bosch, Eva Müssig, Noel Whitaker, Tina Wiest, Annette Kohl, Gerda Komposch, Pascal Tomakidi
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Summary:We report here that the organotypic co-culture (OCC) system allows for significant preservation of the tissue-specific phenotype of human gingival keratinocytes (IHGK) immortalized with the E6/E7 gene of the human papillomavirus type 16 (HPV16). The approach adopted is based on the OCC system facilitating spatially separated cell growth and cell-to-cell interactions via diffusible growth factors.
Item Description:Elektronische Reproduktion der Druck-Ausgabe
Available online 19 November 2009
In der Verfasserangabe ist der zweite Vorname von Franz Xaver Bosch falsch geschrieben
Gesehen am 19.02.2021
Physical Description:Online Resource
ISSN:1432-0436
DOI:10.1111/j.1432-0436.2006.00099.x

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