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Reduction of viral load and immune complex load on CD4+ lymphocytes as a consequence of highly active antiretroviral treatment (HAART) in HIV-infected hemophilia patients

BACKGROUND AND OBJECTIVES: Human immunodeficiency virus (HIV)-induced immune complex load on circulating CD4+ blood lymphocytes is associated with dysfunction and depletion of CD4+ lymphocytes and with increased monocyte/macrophage function. It was investigated whether HAART reduces both the viral l...

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Main Authors: Daniel, Volker (Author) , Süsal, Caner (Author) , Melk, Anette (Author) , Weimer, Rolf (Author) , Kröpelin, M. (Author) , Zimmermann, R. (Author) , Huth-Kühne, A. (Author) , Uhle, C. (Author) , Opelz, Gerhard (Author)
Format: Article (Journal)
Language:English
Published: 1999
In: Immunology letters
Year: 1999, Volume: 69, Issue: 2, Pages: 283-289
ISSN:1879-0542
DOI:10.1016/s0165-2478(99)00105-4
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/s0165-2478(99)00105-4
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165247899001054
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Author Notes:V. Daniel, C. Süsal, A. Melk, R. Weimer, M. Kröpelin, R. Zimmermann, A. Huth-Kühne, C. Uhle, G. Opelz

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520 |a BACKGROUND AND OBJECTIVES: Human immunodeficiency virus (HIV)-induced immune complex load on circulating CD4+ blood lymphocytes is associated with dysfunction and depletion of CD4+ lymphocytes and with increased monocyte/macrophage function. It was investigated whether HAART reduces both the viral load in plasma and the number of immune complex-coated CD4+ lymphocytes in the blood, and whether CD4+ counts are associated with viral load and/or immune complex load. MATERIALS AND METHODS: Twelve HIV+ hemophilia patients before and after conversion to HAART (group 1); eight HIV+ hemophilia patients without antiretroviral therapy (group 2). HIV-1 RNA copies in plasma using NASBA/Nuclisens kits; CD4+ lymphocytes coated in-vivo with immune complexes using flowcytometry on whole blood samples; in-vitro responses of immune complex-coated T lymphocytes in cell culture assays. RESULTS: After conversion to HAART there was a significant reduction of viral load, CD4+ gp120+, CD4+ IgM+, and CD4+ IgG+ circulating blood lymphocytes and plasma neopterin, paralleled by a significant increase of CD4+ and CD8+ counts. The percentage of immune complex-coated CD4+ lymphocytes of converted patients was significantly associated with CD4+ counts, in-vitro responses to concanavalin A (Con A), pokeweed mitogen (PWM), phytohaemagglutinin (PHA), anti-CD3 and pooled allogeneic stimulator cells, and with plasma neopterin levels. CONCLUSION: HAART reduces viral load and HIV-induced immune complex load on circulating CD4+ blood lymphocytes. The results of this study can be interpreted to suggest that HAART increases CD4+ lymphocyte counts in part by counteracting HIV-induced autoimmune phenomena. 
650 4 |a Anti-HIV Agents 
650 4 |a Antibodies, Anti-Idiotypic 
650 4 |a Antigen-Antibody Complex 
650 4 |a Autoantibodies 
650 4 |a Autoimmunity 
650 4 |a CD4-Positive T-Lymphocytes 
650 4 |a Concanavalin A 
650 4 |a Drug Therapy, Combination 
650 4 |a Hemophilia A 
650 4 |a HIV Envelope Protein gp120 
650 4 |a HIV Infections 
650 4 |a HIV Protease Inhibitors 
650 4 |a Humans 
650 4 |a Immunoglobulins 
650 4 |a Lymphocyte Activation 
650 4 |a Lymphocyte Culture Test, Mixed 
650 4 |a Male 
650 4 |a Mitogens 
650 4 |a Reverse Transcriptase Inhibitors 
650 4 |a RNA, Viral 
650 4 |a Viral Load 
650 4 |a Viremia 
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