Cover Image

Cold agglutinin isotypes

Background: Although it is known that IgM κmoleculespredominate in cold agglutinins (CAs), exact data on thefrequency of Ig classes and L-chain types (isotypes) ofCAs and their distribution among CAs with differentspecificities are missing. Material and Methods: 384 CAsof...

Full description

Saved in:
Bibliographic Details
Main Authors: Kreft, Heidi (Author) , Hack, Hildegard (Author) , Roelcke, Dieter (Author)
Format: Article (Journal)
Language:English
Published: 1999
In: Transfusion medicine and hemotherapy
Year: 1999, Volume: 26, Issue: 4, Pages: 240-243
ISSN:1660-3818
DOI:10.1159/000053495
Online Access:Verlag, lizenzpflichtig, Volltext: http://dx.doi.org/10.1159/000053495
Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/53495
Get full text
Author Notes:H. Kreft, H. Hack, D. Roelcke

MARC

LEADER 00000caa a2200000 c 4500
001 1749055260
003 DE-627
005 20230427155520.0
007 cr uuu---uuuuu
008 210222s1999 xx |||||o 00| ||eng c
024 7 |a 10.1159/000053495  |2 doi 
035 |a (DE-627)1749055260 
035 |a (DE-599)KXP1749055260 
035 |a (OCoLC)1341395602 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Kreft, Heidi  |e VerfasserIn  |0 (DE-588)1227862776  |0 (DE-627)1749058049  |4 aut 
245 1 0 |a Cold agglutinin isotypes  |c H. Kreft, H. Hack, D. Roelcke 
264 1 |c 1999 
300 |a 4 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 22.02.2021 
520 |a Background: Although it is known that IgM κmoleculespredominate in cold agglutinins (CAs), exact data on thefrequency of Ig classes and L-chain types (isotypes) ofCAs and their distribution among CAs with differentspecificities are missing. Material and Methods: 384 CAsof our collection were tested for isotypes by double dif-fusion or 2-mercaptoethanol treatment. CA specificitieswere determined using untreated, papain- and sialidase-treated red blood cells derived from human adults andnewborns. Anti-Pr subspecificities were defined bychemically modified glycophorins and further character-ized by specifically α2,3-desialylated red cells. Results:Almost all anti-I CAs are IgM. Almost all IgG and IgA ex-amples are anti-Pr CAs, most of which are IgM. IgG andIgA CAs apparently accumulate within CAs with anti-Pr1hand anti-Prasubspecificities. λ-type IgM CAs are foundamong anti-I (6.5%) and anti-Pr CAs (8.7%) but are pref-erentially associated with anti-i CAs (20.6%). Conclusion:Ig class switching is rare in CAs. It is decisive for themode and extent of red blood cell destruction. Autoim-mune hemolysis due to IgM CAs is complement mediat-ed. Red blood cell destruction induced by IgG CAs differsfrom that caused by IgM CAs, whereas IgA CAs do notcause (intense) immune hemolysis. CA class switching isassociated with CA (sub)specificities. They reflect au-toantigens capable of inducing class switching. 
700 1 |a Hack, Hildegard  |e VerfasserIn  |0 (DE-588)1227863675  |0 (DE-627)1749058634  |4 aut 
700 1 |a Roelcke, Dieter  |d 1936-  |e VerfasserIn  |0 (DE-588)1131952626  |0 (DE-627)887311067  |0 (DE-576)344609472  |4 aut 
773 0 8 |i Enthalten in  |t Transfusion medicine and hemotherapy  |d Basel : Karger, 2003  |g 26(1999), 4, Seite 240-243  |h Online-Ressource  |w (DE-627)360670695  |w (DE-600)2100533-3  |w (DE-576)11277542X  |x 1660-3818  |7 nnas  |a Cold agglutinin isotypes 
773 1 8 |g volume:26  |g year:1999  |g number:4  |g pages:240-243  |g extent:4  |a Cold agglutinin isotypes 
856 4 0 |u http://dx.doi.org/10.1159/000053495  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.karger.com/Article/FullText/53495  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20210222 
993 |a Article 
994 |a 1999 
998 |g 1131952626  |a Roelcke, Dieter  |m 1131952626:Roelcke, Dieter  |d 910000  |d 911600  |e 910000PR1131952626  |e 911600PR1131952626  |k 0/910000/  |k 1/910000/911600/  |p 3  |y j 
998 |g 1227863675  |a Hack, Hildegard  |m 1227863675:Hack, Hildegard  |d 910000  |d 911600  |e 910000PH1227863675  |e 911600PH1227863675  |k 0/910000/  |k 1/910000/911600/  |p 2 
998 |g 1227862776  |a Kreft, Heidi  |m 1227862776:Kreft, Heidi  |d 910000  |d 911600  |e 910000PK1227862776  |e 911600PK1227862776  |k 0/910000/  |k 1/910000/911600/  |p 1  |x j 
999 |a KXP-PPN1749055260  |e 3869214864 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"recId":"1749055260","note":["Gesehen am 22.02.2021"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"given":"Heidi","family":"Kreft","role":"aut","display":"Kreft, Heidi","roleDisplay":"VerfasserIn"},{"display":"Hack, Hildegard","roleDisplay":"VerfasserIn","role":"aut","family":"Hack","given":"Hildegard"},{"given":"Dieter","family":"Roelcke","role":"aut","roleDisplay":"VerfasserIn","display":"Roelcke, Dieter"}],"title":[{"title_sort":"Cold agglutinin isotypes","title":"Cold agglutinin isotypes"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["official organ of German Society for Transfusion Medicine and Immunohematology"]},"origin":[{"publisherPlace":"Basel","dateIssuedKey":"2003","publisher":"Karger","dateIssuedDisp":"2003-"}],"id":{"eki":["360670695"],"zdb":["2100533-3"],"issn":["1660-3818"]},"disp":"Cold agglutinin isotypesTransfusion medicine and hemotherapy","type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 04.05.2023","Fortsetzung der Druck-Ausgabe","Ungezählte Beil.: Supplement"],"language":["eng","ger"],"recId":"360670695","pubHistory":["30.2003 -"],"part":{"pages":"240-243","issue":"4","year":"1999","extent":"4","volume":"26","text":"26(1999), 4, Seite 240-243"},"titleAlt":[{"title":"offizielles Organ der Deutschen Gesellschaft für Transfusionsmedizin und Immunhämatologie ; interdisziplinäre Zeitschrift für Infusions- und Hämotherapie, Immunhämatologie und klinische Hämostaseologie"}],"title":[{"title_sort":"Transfusion medicine and hemotherapy","subtitle":"interdisciplinary journal for transfusion medicine, hemotherapy, immunohematology, and clinical hemostatis","title":"Transfusion medicine and hemotherapy"}]}],"physDesc":[{"extent":"4 S."}],"name":{"displayForm":["H. Kreft, H. Hack, D. Roelcke"]},"id":{"doi":["10.1159/000053495"],"eki":["1749055260"]},"origin":[{"dateIssuedDisp":"1999","dateIssuedKey":"1999"}]} 
SRT |a KREFTHEIDICOLDAGGLUT1999 

Similar Items