Cofilin peptide homologs interfere with immunological synapse formation and T cell activation
The formation of supramolecular activation clusters within the immunological synapse, crucial for sustained signaling and T lymphocyte activation, requires costimulation-dependent reorganization of the actin cytoskeleton. Here we have identified the actin-remodeling protein cofilin as a key player i...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 3, 2004
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| In: |
Proceedings of the National Academy of Sciences of the United States of America
Year: 2004, Jahrgang: 101, Heft: 7, Pages: 1957-1962 |
| ISSN: | 1091-6490 |
| DOI: | 10.1073/pnas.0308282100 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1073/pnas.0308282100 Verlag, lizenzpflichtig, Volltext: https://www.pnas.org/content/101/7/1957 
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| Verfasserangaben: | Sybille M. Eibert, Kyeong-Hee Lee, Rüdiger Pipkorn, Urban Sester, Guido H. Wabnitz, Thomas Giese, Stefan C. Meuer, and Yvonne Samstag |
MARC
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| 245 | 1 | 0 | |a Cofilin peptide homologs interfere with immunological synapse formation and T cell activation |c Sybille M. Eibert, Kyeong-Hee Lee, Rüdiger Pipkorn, Urban Sester, Guido H. Wabnitz, Thomas Giese, Stefan C. Meuer, and Yvonne Samstag |
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| 520 | |a The formation of supramolecular activation clusters within the immunological synapse, crucial for sustained signaling and T lymphocyte activation, requires costimulation-dependent reorganization of the actin cytoskeleton. Here we have identified the actin-remodeling protein cofilin as a key player in this process. Cell-permeable peptides that block costimulation-induced cofilin/F-actin interactions in untransformed human T lymphocytes impair receptor capping and immunological synapse formation at the interface between T cells and antigen-presenting cells. As a consequence, T cell activation, as measured by cytokine production and proliferation, is inhibited. | ||
| 650 | 4 | |a Actin Depolymerizing Factors | |
| 650 | 4 | |a Actins | |
| 650 | 4 | |a Antigen-Presenting Cells | |
| 650 | 4 | |a Carrier Proteins | |
| 650 | 4 | |a CD2 Antigens | |
| 650 | 4 | |a Cell Division | |
| 650 | 4 | |a Cell Line, Tumor | |
| 650 | 4 | |a Cell Membrane Permeability | |
| 650 | 4 | |a Cell-Penetrating Peptides | |
| 650 | 4 | |a Cells, Cultured | |
| 650 | 4 | |a Cytokines | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Immunologic Capping | |
| 650 | 4 | |a Isoantigens | |
| 650 | 4 | |a Lymphocyte Activation | |
| 650 | 4 | |a Microfilament Proteins | |
| 650 | 4 | |a Peptides | |
| 650 | 4 | |a Protein Binding | |
| 650 | 4 | |a T-Lymphocytes | |
| 650 | 4 | |a Th1 Cells | |
| 650 | 4 | |a Th2 Cells | |
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| 700 | 1 | |a Samstag, Yvonne |e VerfasserIn |0 (DE-588)1056828285 |0 (DE-627)794131794 |0 (DE-576)170331059 |4 aut | |
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