Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells
Aerobic glycolysis, discovered by Otto Warburg, is a hallmark of cancer metabolism even though not yet fully understood. The low activity of the cancerous pyruvate kinase isozyme (M2) is thought to play an important role by facilitating the conversion of glycolytic intermediates to other anabolic pa...
Gespeichert in:
| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
22 January 2021
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| In: |
Cancer & metabolism
Year: 2021, Jahrgang: 9, Heft: 1 |
| ISSN: | 2049-3002 |
| DOI: | 10.1186/s40170-021-00239-8 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s40170-021-00239-8 Verlag, kostenfrei, Volltext: https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00239-8 
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| Verfasserangaben: | Fadi Almouhanna, Biljana Blagojevic, Suzan Can, Ali Ghanem and Stefan Wölfl |
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| 520 | |a Aerobic glycolysis, discovered by Otto Warburg, is a hallmark of cancer metabolism even though not yet fully understood. The low activity of the cancerous pyruvate kinase isozyme (M2) is thought to play an important role by facilitating the conversion of glycolytic intermediates to other anabolic pathways to support tumors’ high proliferation rate. | ||
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| 650 | 4 | |a Breast cancer | |
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| 650 | 4 | |a Pyruvate kinase M2 | |
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