Electron tomography of plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion
Erythrocyte invasion by merozoites forms of the malaria parasite is a key step in the establishment of human malaria disease. To date, efforts to understand cellular events underpinning entry have been limited to insights from non-human parasites, with no studies at sub-micrometer resolution underta...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
22 March 2013
|
| In: |
Cellular microbiology
Year: 2013, Jahrgang: 15, Heft: 9, Pages: 1457-1472 |
| ISSN: | 1462-5822 |
| DOI: | https://doi.org/10.1111/cmi.12132 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1111/cmi.12132 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.12132 
|
| Verfasserangaben: | Eric Hanssen, Chaitali Dekiwadia, David T. Riglar, Melanie Rug, Leandro Lemgruber, Alan F. Cowman, Marek Cyrklaff, Mikhail Kudryashev, Friedrich Frischknecht, Jake Baum and Stuart A. Ralph |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1749369419 | ||
| 003 | DE-627 | ||
| 005 | 20230428020551.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210225s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/cmi.12132 |2 doi | |
| 035 | |a (DE-627)1749369419 | ||
| 035 | |a (DE-599)KXP1749369419 | ||
| 035 | |a (OCoLC)1341396164 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hanssen, Eric |e VerfasserIn |0 (DE-588)1228195595 |0 (DE-627)1749538377 |4 aut | |
| 245 | 1 | 0 | |a Electron tomography of plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion |c Eric Hanssen, Chaitali Dekiwadia, David T. Riglar, Melanie Rug, Leandro Lemgruber, Alan F. Cowman, Marek Cyrklaff, Mikhail Kudryashev, Friedrich Frischknecht, Jake Baum and Stuart A. Ralph |
| 264 | 1 | |c 22 March 2013 | |
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 26.02.2021 | ||
| 520 | |a Erythrocyte invasion by merozoites forms of the malaria parasite is a key step in the establishment of human malaria disease. To date, efforts to understand cellular events underpinning entry have been limited to insights from non-human parasites, with no studies at sub-micrometer resolution undertaken using the most virulent human malaria parasite, Plasmodium falciparum. This leaves our understanding of the dynamics of merozoite sub-cellular compartments during infectionincomplete, in particular that of the secretory organelles. Using advances in P. falciparum merozoite isolation and new imaging techniques we present a three-dimensional study of invasion using electron microscopy, cryo-electron tomography and cryo-X-ray tomography. We describe the core architectural features of invasion and identify fusion between rhoptries at the commencement of invasion as a hitherto overlooked event that likely provides a critical step that initiates entry. Given the centrality of merozoite organelle proteins to vaccine development, these insights provide a mechanistic framework to understand therapeutic strategies targeted towards the cellular events of invasion. | ||
| 700 | 1 | |a Cyrklaff, Marek |e VerfasserIn |0 (DE-588)1079241507 |0 (DE-627)840669623 |0 (DE-576)452286921 |4 aut | |
| 700 | 1 | |a Frischknecht, Friedrich |d 1968- |e VerfasserIn |0 (DE-588)122362160 |0 (DE-627)705878392 |0 (DE-576)293237298 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cellular microbiology |d [Hoboken, NJ] : Wiley, 1999 |g 15(2013), 9, Seite 1457-1472 |h Online-Ressource |w (DE-627)320599493 |w (DE-600)2019990-9 |w (DE-576)091140889 |x 1462-5822 |7 nnas |a Electron tomography of plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion |
| 773 | 1 | 8 | |g volume:15 |g year:2013 |g number:9 |g pages:1457-1472 |g extent:16 |a Electron tomography of plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion |
| 856 | 4 | 0 | |u https://doi.org/https://doi.org/10.1111/cmi.12132 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.12132 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210225 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 122362160 |a Frischknecht, Friedrich |m 122362160:Frischknecht, Friedrich |d 50000 |e 50000PF122362160 |k 0/50000/ |p 9 | ||
| 998 | |g 1079241507 |a Cyrklaff, Marek |m 1079241507:Cyrklaff, Marek |d 910000 |d 911700 |e 910000PC1079241507 |e 911700PC1079241507 |k 0/910000/ |k 1/910000/911700/ |p 7 | ||
| 999 | |a KXP-PPN1749369419 |e 3874184250 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1111/cmi.12132"],"eki":["1749369419"]},"person":[{"given":"Eric","family":"Hanssen","display":"Hanssen, Eric","role":"aut"},{"role":"aut","display":"Cyrklaff, Marek","family":"Cyrklaff","given":"Marek"},{"family":"Frischknecht","display":"Frischknecht, Friedrich","role":"aut","given":"Friedrich"}],"origin":[{"dateIssuedDisp":"22 March 2013","dateIssuedKey":"2013"}],"title":[{"title":"Electron tomography of plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion","title_sort":"Electron tomography of plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion"}],"name":{"displayForm":["Eric Hanssen, Chaitali Dekiwadia, David T. Riglar, Melanie Rug, Leandro Lemgruber, Alan F. Cowman, Marek Cyrklaff, Mikhail Kudryashev, Friedrich Frischknecht, Jake Baum and Stuart A. Ralph"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1749369419","physDesc":[{"extent":"16 S."}],"relHost":[{"id":{"eki":["320599493"],"issn":["1462-5822"],"zdb":["2019990-9"],"doi":["10.1111/(ISSN)1462-5822"]},"part":{"year":"2013","text":"15(2013), 9, Seite 1457-1472","pages":"1457-1472","issue":"9","extent":"16","volume":"15"},"origin":[{"dateIssuedKey":"2024","publisherPlace":"[Hoboken, NJ] ; Oxford ; Oxford [u.a.] ; Oxford [u.a.] ; London","publisher":"Wiley ; Blackwell Science ; Blackwell ; Wiley-Blackwell ; Hindawi Limited","dateIssuedDisp":"2024-"}],"disp":"Electron tomography of plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasionCellular microbiology","title":[{"title":"Cellular microbiology","title_sort":"Cellular microbiology"}],"pubHistory":["1.1999-"],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"320599493","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 31.01.2025","Fortsetzung der Druck-Ausgabe"]}],"language":["eng"],"note":["Gesehen am 26.02.2021"]} | ||
| SRT | |a HANSSENERIELECTRONTO2220 | ||