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Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα

Rhomboid intramembrane proteases are the enzymes that release active epidermal growth factor receptor (EGFR) ligands in Drosophila and C. elegans, but little is known about their functions in mammals. Here we show that the mammalian rhomboid protease RHBDL4 (also known as Rhbdd1) promotes traffickin...

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Main Authors: Wunderle, Lina (Author) , Knopf, Julia Daniela (Author) , Kühnle, Nathalie (Author) , Morlé, Aymeric (Author) , Geiger, Beate (Author) , Adrain, Colin (Author) , Strisovsky, Kvido (Author) , Freeman, Matthew (Author) , Lemberg, Marius (Author)
Format: Article (Journal)
Language:English
Published: 06 June 2016
In: Scientific reports
Year: 2016, Volume: 6, Pages: 1-15
ISSN:2045-2322
DOI:10.1038/srep27342
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/srep27342
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/srep27342
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Author Notes:Lina Wunderle, Julia D. Knopf, Nathalie Kühnle, Aymeric Morlé, Beate Hehn, Colin Adrain, Kvido Strisovsky, Matthew Freeman & Marius K. Lemberg

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