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Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome

Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in primary and relapsed neuroblastomas (n = 760) and characterize its features using multi-omics profiling.

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Bibliographic Details
Main Authors: Stainczyk, Sabine (Author) , Sieverling, Lina (Author) , Nadler-Holly, Michal (Author) , Ziehm, Matthias (Author) , Toprak, Umut H. (Author) , Herrmann, Carl (Author) , Ishaque, Naveed (Author) , Okonechnikov, Konstantin (Author) , Gartlgruber, Moritz (Author) , Park, Young-Gyu (Author) , Wecht, Elisa Maria (Author) , Savelyeva, Larissa (Author) , Henrich, Kai-Oliver (Author) , Rosswog, Carolina (Author) , Fischer, Matthias (Author) , Hero, Barbara (Author) , Jones, David T. W. (Author) , Pfaff, Elke (Author) , Witt, Olaf (Author) , Pfister, Stefan (Author) , Volckmann, Richard (Author) , Koster, Jan (Author) , Kiesel, Katharina (Author) , Rippe, Karsten (Author) , Taschner-Mandl, Sabine (Author) , Ambros, Peter (Author) , Brors, Benedikt (Author) , Selbach, Matthias (Author) , Feuerbach, Lars (Author) , Westermann, Frank (Author)
Format: Article (Journal)
Language:English
Published: 24 February 2021
In: Nature Communications
Year: 2021, Volume: 12, Pages: 1-18
ISSN:2041-1723
DOI:10.1038/s41467-021-21247-8
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-021-21247-8
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-021-21247-8
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Author Notes:Sabine A. Hartlieb, Lina Sieverling, Michal Nadler-Holly, Matthias Ziehm, Umut H. Toprak, Carl Herrmann, Naveed Ishaque, Konstantin Okonechnikov, Moritz Gartlgruber, Young-Gyu Park, Elisa Maria Wecht, Larissa Savelyeva, Kai-Oliver Henrich, Carolina Rosswog, Matthias Fischer, Barbara Hero, David T.W. Jones, Elke Pfaff, Olaf Witt, Stefan M. Pfister, Richard Volckmann, Jan Koster, Katharina Kiesel, Karsten Rippe, Sabine Taschner-Mandl, Peter Ambros, Benedikt Brors, Matthias Selbach, Lars Feuerbach, Frank Westermann
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Summary:Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in primary and relapsed neuroblastomas (n = 760) and characterize its features using multi-omics profiling.
Item Description:Gesehen am 26.02.2021
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-021-21247-8

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