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Lecithin retinol acyltransferase as a potential prognostic marker for malignant melanoma

Metabolism inside cells differs between cancer and normal cells. Because disturbance of vitamin A metabolism might be important, we investigated expression of the enzymes lecithin retinol acyltransferase (LRAT) and RPE65 by immunohistochemistry in melanoma metastases and melanocytic nevi. Semiquanti...

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Main Authors: Hassel, Jessica C. (Author) , Amann, Philipp M. (Author) , Schadendorf, Dirk (Author) , Eichmüller, Stefan B. (Author) , Nagler, Markus (Author) , Bazhin, Alexandr V. (Author)
Format: Article (Journal) Editorial
Language:English
Published: 05 September 2013
In: Experimental dermatology
Year: 2013, Volume: 22, Issue: 11, Pages: 757-759
ISSN:1600-0625
DOI:https://doi.org/10.1111/exd.12236
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1111/exd.12236
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.12236
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Author Notes:Jessica C. Hassel, Philipp M. Amann, Dirk Schadendorf, Stefan B. Eichmüller, Markus Nagler and Alexandr V. Bazhin

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520 |a Metabolism inside cells differs between cancer and normal cells. Because disturbance of vitamin A metabolism might be important, we investigated expression of the enzymes lecithin retinol acyltransferase (LRAT) and RPE65 by immunohistochemistry in melanoma metastases and melanocytic nevi. Semiquantitative evaluation of this expression revealed downregulated expression of RPE65 in malignant melanoma compared with benign melanocytic nevi (P < 0.001). In contrast, expression of LRAT was not significantly different (P = 0.339). High LRAT expression in melanoma metastases was inversely correlated with patient survival; Kaplan-Meier analysis revealed earlier melanoma-related death (P = 0.003). Expression of LRAT might, therefore, be a prognostic marker of the clinical course of melanoma. 
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