Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection
Cytotoxic T lymphocytes (CTL) play a major role in the recovery from primary viral infections and the accompanying tissue injuries. However, it is unclear to what extent the two main cytolytic pathways, perforin-granzyme A and B exocytosis and Fas ligand (FasL)-Fas interaction, contribute to these p...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2001
|
| In: |
Journal of virology
Year: 2001, Volume: 75, Issue: 18, Pages: 8781-8791 |
| ISSN: | 1098-5514 |
| DOI: | 10.1128/JVI.75.18.8781-8791.2001 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://dx.doi.org/10.1128/JVI.75.18.8781-8791.2001 Verlag, lizenzpflichtig, Volltext: https://jvi.asm.org/content/75/18/8781 
|
| Author Notes: | Sandra Balkow, Astrid Kersten, Thi Thanh Thao Tran, Thomas Stehle, Philipp Grosse, Crisan Museteanu, Olaf Utermöhlen, Hanspeter Pircher, Fritz von Weizsäcker, Reinhard Wallich, Arno Müllbacher, and Markus M. Simon |
MARC
| LEADER | 00000caa a2200000 4500 | ||
|---|---|---|---|
| 001 | 1749528061 | ||
| 003 | DE-627 | ||
| 005 | 20230428020616.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210226s2001 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1128/JVI.75.18.8781-8791.2001 |2 doi | |
| 035 | |a (DE-627)1749528061 | ||
| 035 | |a (DE-599)KXP1749528061 | ||
| 035 | |a (OCoLC)1341396407 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Balkow, Sandra |e VerfasserIn |0 (DE-588)1228185646 |0 (DE-627)174952886X |4 aut | |
| 245 | 1 | 0 | |a Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection |c Sandra Balkow, Astrid Kersten, Thi Thanh Thao Tran, Thomas Stehle, Philipp Grosse, Crisan Museteanu, Olaf Utermöhlen, Hanspeter Pircher, Fritz von Weizsäcker, Reinhard Wallich, Arno Müllbacher, and Markus M. Simon |
| 264 | 1 | |c 2001 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 26.02.2021 | ||
| 520 | |a Cytotoxic T lymphocytes (CTL) play a major role in the recovery from primary viral infections and the accompanying tissue injuries. However, it is unclear to what extent the two main cytolytic pathways, perforin-granzyme A and B exocytosis and Fas ligand (FasL)-Fas interaction, contribute to these processes. Here we have employed mouse strains with either spontaneous mutations or targeted gene defects in one or more components of either of the two cytolytic pathways to analyze the molecular basis of viral clearance and induction of hepatitis during lymphocytic choriomeningitis virus infection. Our results reveal that viral clearance is solely dependent on perforin but that virus-induced liver damage only occurs when both the FasL/Fas and the perforin pathways, including granzymes A and B, are simultaneously activated. The finding that development of hepatitis but not viral clearance is dependent on the concomitant activation of FasL-Fas and perforin-granzymes may be helpful in designing novel strategies to prevent hepatic failures during viral infections. | ||
| 700 | 1 | |a Kersten, Astrid |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tran, Thi Thanh Thao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stehle, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grosse, Philipp |e VerfasserIn |4 aut | |
| 700 | 1 | |a Museteanu, Crisan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Utermöhlen, Olaf |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pircher, Hanspeter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weizsäcker, Fritz von |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wallich, Reinhard |e VerfasserIn |0 (DE-588)1059566710 |0 (DE-627)798640839 |0 (DE-576)163467781 |4 aut | |
| 700 | 1 | |a Müllbacher, Arno |e VerfasserIn |4 aut | |
| 700 | 1 | |a Simon, Markus M. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of virology |d Baltimore, Md. : Soc., 1967 |g 75(2001), 18, Seite 8781-8791 |h Online-Ressource |w (DE-627)303614609 |w (DE-600)1495529-5 |w (DE-576)08088766X |x 1098-5514 |7 nnns |a Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection |
| 773 | 1 | 8 | |g volume:75 |g year:2001 |g number:18 |g pages:8781-8791 |g extent:11 |a Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1128/JVI.75.18.8781-8791.2001 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://jvi.asm.org/content/75/18/8781 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210226 | ||
| 993 | |a Article | ||
| 994 | |a 2001 | ||
| 998 | |g 1059566710 |a Wallich, Reinhard |m 1059566710:Wallich, Reinhard |d 910000 |d 911600 |e 910000PW1059566710 |e 911600PW1059566710 |k 0/910000/ |k 1/910000/911600/ |p 10 | ||
| 999 | |a KXP-PPN1749528061 |e 387612008X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 26.02.2021"],"language":["eng"],"person":[{"role":"aut","display":"Balkow, Sandra","family":"Balkow","given":"Sandra","roleDisplay":"VerfasserIn"},{"display":"Kersten, Astrid","role":"aut","family":"Kersten","given":"Astrid","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","given":"Thi Thanh Thao","family":"Tran","display":"Tran, Thi Thanh Thao","role":"aut"},{"roleDisplay":"VerfasserIn","given":"Thomas","family":"Stehle","role":"aut","display":"Stehle, Thomas"},{"role":"aut","display":"Grosse, Philipp","family":"Grosse","given":"Philipp","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","given":"Crisan","family":"Museteanu","display":"Museteanu, Crisan","role":"aut"},{"given":"Olaf","roleDisplay":"VerfasserIn","role":"aut","display":"Utermöhlen, Olaf","family":"Utermöhlen"},{"family":"Pircher","role":"aut","display":"Pircher, Hanspeter","roleDisplay":"VerfasserIn","given":"Hanspeter"},{"role":"aut","display":"Weizsäcker, Fritz von","family":"Weizsäcker","given":"Fritz von","roleDisplay":"VerfasserIn"},{"given":"Reinhard","roleDisplay":"VerfasserIn","display":"Wallich, Reinhard","role":"aut","family":"Wallich"},{"family":"Müllbacher","role":"aut","display":"Müllbacher, Arno","roleDisplay":"VerfasserIn","given":"Arno"},{"display":"Simon, Markus M.","role":"aut","family":"Simon","given":"Markus M.","roleDisplay":"VerfasserIn"}],"physDesc":[{"extent":"S.11"}],"name":{"displayForm":["Sandra Balkow, Astrid Kersten, Thi Thanh Thao Tran, Thomas Stehle, Philipp Grosse, Crisan Museteanu, Olaf Utermöhlen, Hanspeter Pircher, Fritz von Weizsäcker, Reinhard Wallich, Arno Müllbacher, and Markus M. Simon"]},"title":[{"title_sort":"Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection","title":"Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection"}],"origin":[{"dateIssuedDisp":"2001","dateIssuedKey":"2001"}],"recId":"1749528061","type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["1749528061"],"doi":["10.1128/JVI.75.18.8781-8791.2001"]},"relHost":[{"id":{"issn":["1098-5514"],"eki":["303614609"],"zdb":["1495529-5"]},"recId":"303614609","corporate":[{"roleDisplay":"Herausgebendes Organ","role":"isb","display":"American Society for Microbiology"}],"title":[{"title_sort":"Journal of virology","subtitle":"publ. by the American Society for Microbiology","title":"Journal of virology"}],"note":["Gesehen am 13.12.2021"],"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"dateIssuedKey":"1967","publisherPlace":"Baltimore, Md.","publisher":"Soc.","dateIssuedDisp":"1967-"}],"part":{"volume":"75","issue":"18","pages":"8781-8791","text":"75(2001), 18, Seite 8781-8791","extent":"11","year":"2001"},"pubHistory":["1.1967 -"],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"disp":"Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infectionJournal of virology"}]} | ||
| SRT | |a BALKOWSANDCONCERTEDA2001 | ||