Regional cerebral perfusion alterations in patients with mild cognitive impairment and Alzheimer disease using dynamic susceptibility contrast MRI
Rationale and Objectives - The purpose of this study was to assess regional cerebral perfusion distribution in patients with Alzheimer disease (AD) or mild cognitive impairment (MCI) using dynamic susceptibility contrast magnetic resonance imaging. - Materials and Methods - Regional changes of perfu...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
7 May 2013
|
| In: |
Academic radiology
Year: 2013, Jahrgang: 20, Heft: 6, Pages: 705-711 |
| ISSN: | 1878-4046 |
| DOI: | 10.1016/j.acra.2013.01.020 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.acra.2013.01.020 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1076633213001098 
|
| Verfasserangaben: | Thomas Hauser MD, Peter Schönknecht MD, Philipp A. Thomann MD, Lars Gerigk MD, Johannes Schröder MD, Romy Henze Ph, Alexander Radbruch MD, Marco Essig MD, PhD |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1750022133 | ||
| 003 | DE-627 | ||
| 005 | 20220819122647.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210301s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.acra.2013.01.020 |2 doi | |
| 035 | |a (DE-627)1750022133 | ||
| 035 | |a (DE-599)KXP1750022133 | ||
| 035 | |a (OCoLC)1341396525 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hauser, Thomas |d 1979- |e VerfasserIn |0 (DE-588)1146836317 |0 (DE-627)1005936838 |0 (DE-576)255374267 |4 aut | |
| 245 | 1 | 0 | |a Regional cerebral perfusion alterations in patients with mild cognitive impairment and Alzheimer disease using dynamic susceptibility contrast MRI |c Thomas Hauser MD, Peter Schönknecht MD, Philipp A. Thomann MD, Lars Gerigk MD, Johannes Schröder MD, Romy Henze Ph, Alexander Radbruch MD, Marco Essig MD, PhD |
| 264 | 1 | |c 7 May 2013 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 02.03.2021 | ||
| 520 | |a Rationale and Objectives - The purpose of this study was to assess regional cerebral perfusion distribution in patients with Alzheimer disease (AD) or mild cognitive impairment (MCI) using dynamic susceptibility contrast magnetic resonance imaging. - Materials and Methods - Regional changes of perfusion were evaluated in 34 patients with AD, 51 patients with MCI, and 23 healthy controls (HCs). Using region of interest analyses, regional cerebral blood flow (CBF), cerebral blood volume, and mean transit time were measured bilaterally in the hippocampus; the temporal, temporoparietal, frontal, and sensomotoric cortices; the anterior and posterior cingulate gyri; the lentiform nucleus; and the cerebellum. - Results - A significant reduction of CBF in patients with AD compared to HCs was shown in the frontal and temporoparietal cortices bilaterally, the lentiform nuclei bilaterally, the left posterior cingulate gyrus, and the cerebellum. Compared with patients with MCI, patients with AD presented a reduction of CBF in the frontal cortices bilaterally, the left temporoparietal cortex, and the left anterior and posterior cingulate gyrus. In both hippocampi and the posterior cingulate gyrus, a trend to a slight increase of CBF in patients with MCI was noticed with a decrease in patients with AD. - Conclusions - Using dynamic susceptibility contrast magnetic resonance imaging, pathologic alterations of regional brain perfusion can be demonstrated in patients with AD compared to patients with MCI or HCs. | ||
| 650 | 4 | |a Alzheimer dementia | |
| 650 | 4 | |a cerebral blood flow | |
| 650 | 4 | |a dynamic susceptibility contrast MRI | |
| 650 | 4 | |a mild cognitive impairment | |
| 650 | 4 | |a regional perfusion alteration | |
| 700 | 1 | |a Schönknecht, Peter |d 1970- |e VerfasserIn |0 (DE-588)118117653 |0 (DE-627)079253741 |0 (DE-576)291724337 |4 aut | |
| 700 | 1 | |a Thomann, Philipp |d 1974- |e VerfasserIn |0 (DE-588)130517224 |0 (DE-627)503035149 |0 (DE-576)298243571 |4 aut | |
| 700 | 1 | |a Gerigk, Lars |d 1973- |e VerfasserIn |0 (DE-588)137920954 |0 (DE-627)69618558X |0 (DE-576)30587330X |4 aut | |
| 700 | 1 | |a Schröder, Johannes |d 1957- |e VerfasserIn |0 (DE-588)138708517 |0 (DE-627)605263469 |0 (DE-576)308769848 |4 aut | |
| 700 | 1 | |a Henze, Romy |d 1976- |e VerfasserIn |0 (DE-588)1013138392 |0 (DE-627)663810817 |0 (DE-576)274522918 |4 aut | |
| 700 | 1 | |a Radbruch, Alexander |d 1977- |e VerfasserIn |0 (DE-588)1022344501 |0 (DE-627)716953951 |0 (DE-576)362851166 |4 aut | |
| 700 | 1 | |a Essig, Marco |e VerfasserIn |0 (DE-588)1048464490 |0 (DE-627)780470605 |0 (DE-576)172458595 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Academic radiology |d Philadelphia, PA [u.a.] : Elsevier, 1994 |g 20(2013), 6, Seite 705-711 |h Online-Ressource |w (DE-627)331018667 |w (DE-600)2050425-1 |w (DE-576)271497602 |x 1878-4046 |7 nnas |a Regional cerebral perfusion alterations in patients with mild cognitive impairment and Alzheimer disease using dynamic susceptibility contrast MRI |
| 773 | 1 | 8 | |g volume:20 |g year:2013 |g number:6 |g pages:705-711 |g extent:7 |a Regional cerebral perfusion alterations in patients with mild cognitive impairment and Alzheimer disease using dynamic susceptibility contrast MRI |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.acra.2013.01.020 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1076633213001098 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210301 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1048464490 |a Essig, Marco |m 1048464490:Essig, Marco |d 50000 |e 50000PE1048464490 |k 0/50000/ |p 8 |y j | ||
| 998 | |g 1022344501 |a Radbruch, Alexander |m 1022344501:Radbruch, Alexander |d 50000 |e 50000PR1022344501 |k 0/50000/ |p 7 | ||
| 998 | |g 1013138392 |a Henze, Romy |m 1013138392:Henze, Romy |p 6 | ||
| 998 | |g 138708517 |a Schröder, Johannes |m 138708517:Schröder, Johannes |d 50000 |e 50000PS138708517 |k 0/50000/ |p 5 | ||
| 998 | |g 137920954 |a Gerigk, Lars |m 137920954:Gerigk, Lars |p 4 | ||
| 998 | |g 130517224 |a Thomann, Philipp |m 130517224:Thomann, Philipp |d 910000 |d 910600 |d 50000 |e 910000PT130517224 |e 910600PT130517224 |e 50000PT130517224 |k 0/910000/ |k 1/910000/910600/ |k 0/50000/ |p 3 | ||
| 998 | |g 118117653 |a Schönknecht, Peter |m 118117653:Schönknecht, Peter |p 2 | ||
| 998 | |g 1146836317 |a Hauser, Thomas |m 1146836317:Hauser, Thomas |d 50000 |e 50000PH1146836317 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1750022133 |e 3879679118 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Thomas Hauser MD, Peter Schönknecht MD, Philipp A. Thomann MD, Lars Gerigk MD, Johannes Schröder MD, Romy Henze Ph, Alexander Radbruch MD, Marco Essig MD, PhD"]},"person":[{"display":"Hauser, Thomas","role":"aut","given":"Thomas","family":"Hauser"},{"display":"Schönknecht, Peter","given":"Peter","role":"aut","family":"Schönknecht"},{"family":"Thomann","display":"Thomann, Philipp","role":"aut","given":"Philipp"},{"family":"Gerigk","role":"aut","given":"Lars","display":"Gerigk, Lars"},{"given":"Johannes","role":"aut","display":"Schröder, Johannes","family":"Schröder"},{"display":"Henze, Romy","given":"Romy","role":"aut","family":"Henze"},{"family":"Radbruch","given":"Alexander","role":"aut","display":"Radbruch, Alexander"},{"family":"Essig","role":"aut","given":"Marco","display":"Essig, Marco"}],"recId":"1750022133","origin":[{"dateIssuedDisp":"7 May 2013","dateIssuedKey":"2013"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["331018667"],"zdb":["2050425-1"],"issn":["1878-4046"]},"disp":"Regional cerebral perfusion alterations in patients with mild cognitive impairment and Alzheimer disease using dynamic susceptibility contrast MRIAcademic radiology","note":["Gesehen am 18.04.17"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"331018667","origin":[{"publisherPlace":"Philadelphia, PA [u.a.] ; Oak Brook, Ill.","publisher":"Elsevier ; Assoc. of University Radiologists","dateIssuedDisp":"1994-","dateIssuedKey":"1994"}],"pubHistory":["1.1994 -"],"title":[{"title_sort":"Academic radiology","title":"Academic radiology","subtitle":"official journal of the Association of University Radiologists, the Society of Chairs of Academic Radiology Departments, the Association of Program Directors in Radiology, the American Alliance of Academic Chief Residents in Radiology, the Alliance of Medical Student Educators in Radiology, the Radiology Research Alliance, the Radiology Alliance for Health Services Research, and the Medical Image Computing and Computer-Assisted Intervention Society"}],"part":{"pages":"705-711","extent":"7","issue":"6","volume":"20","text":"20(2013), 6, Seite 705-711","year":"2013"},"language":["eng"]}],"note":["Gesehen am 02.03.2021"],"id":{"doi":["10.1016/j.acra.2013.01.020"],"eki":["1750022133"]},"physDesc":[{"extent":"7 S."}],"language":["eng"],"title":[{"title_sort":"Regional cerebral perfusion alterations in patients with mild cognitive impairment and Alzheimer disease using dynamic susceptibility contrast MRI","title":"Regional cerebral perfusion alterations in patients with mild cognitive impairment and Alzheimer disease using dynamic susceptibility contrast MRI"}]} | ||
| SRT | |a HAUSERTHOMREGIONALCE7201 | ||