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Regulatory T cell-deficient scurfy mice develop systemic autoimmune features resembling lupus-like disease

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Scurfy mice are deficient in regulatory T cells (Tregs), develop a severe, generalized autoimmune disorder that can affect almost every organ and die at an early age. Some of these manifestations resemble those found in systemic lupus erythematosus (SLE). In addition, active SLE is associated with l...

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Main Authors: Hadaschik, Eva (Author) , Wei, Xiaoying (Author) , Leiss, Harald (Author) , Heckmann, Britta (Author) , Niederreiter, Birgit (Author) , Steiner, Günter (Author) , Ulrich, Walter (Author) , Enk, Alexander (Author) , Smolen, Josef S. (Author) , Stummvoll, Georg (Author)
Format: Article (Journal)
Language:English
Published: 23 February 2015
In: Arthritis Research & Therapy
Year: 2015, Volume: 17, Pages: 1-12
ISSN:1465-9913
DOI:10.1186/s13075-015-0538-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13075-015-0538-0
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Author Notes:Eva N. Hadaschik, Xiaoying Wei, Harald Leiss, Britta Heckmann, Birgit Niederreiter, Günter Steiner, Walter Ulrich, Alexander H. Enk, Josef S. Smolen and Georg H. Stummvoll
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Regulatory T cell-deficient scurfy mice develop systemic autoimmune features resembling lupus-like disease by Hadaschik, Eva (Author) , Heckmann, Britta (Author) , Enk, Alexander (Author) ,

BioMed Central 2015

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