Rage signalling promotes intestinal tumourigenesis
Development of colon cancer is a multistep process that is regulated by intrinsic and extrinsic cellular signals. Extrinsic factors include molecular patterns that are derived from either pathogens (PAMPs) or cellular damage (DAMPs). These molecules can promote tumourigenesis by activation of the in...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2013
|
| In: |
Oncogene
Year: 2013, Volume: 32, Issue: 9, Pages: 1202-1206 |
| ISSN: | 1476-5594 |
| DOI: | 10.1038/onc.2012.119 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/onc.2012.119 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/onc2012119 
|
| Author Notes: | J. Heijmans, N.V.J.A. Büller, E. Hoff, A.A. Dihal, T. van der Poll, M.A.D. van Zoelen, A. Bierhaus, I. Biemond, J.C.H. Hardwick, D.W. Hommes, V. Muncan, and G.R. van den Brink |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1750102196 | ||
| 003 | DE-627 | ||
| 005 | 20251101213215.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210302s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/onc.2012.119 |2 doi | |
| 035 | |a (DE-627)1750102196 | ||
| 035 | |a (DE-599)KXP1750102196 | ||
| 035 | |a (OCoLC)1341396539 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Heijmans, Jarom |e VerfasserIn |0 (DE-588)1229143769 |0 (DE-627)1751153347 |4 aut | |
| 245 | 1 | 0 | |a Rage signalling promotes intestinal tumourigenesis |c J. Heijmans, N.V.J.A. Büller, E. Hoff, A.A. Dihal, T. van der Poll, M.A.D. van Zoelen, A. Bierhaus, I. Biemond, J.C.H. Hardwick, D.W. Hommes, V. Muncan, and G.R. van den Brink |
| 264 | 1 | |c 2013 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online 2 April 2012 | ||
| 500 | |a Gesehen am 08.10.2021 | ||
| 520 | |a Development of colon cancer is a multistep process that is regulated by intrinsic and extrinsic cellular signals. Extrinsic factors include molecular patterns that are derived from either pathogens (PAMPs) or cellular damage (DAMPs). These molecules can promote tumourigenesis by activation of the innate immune system, but the individual contribution of ligands and their receptors remains elusive. The receptor for advanced glycation end products (Rage) is a pattern recognition receptor that binds multiple ligands derived from a damaged cell environment such as Hmgb1 and S100 protein. Here we show that Rage signalling has a critical role in sporadic development of intestinal adenomas, as ApcMin/+ Rage−/− mice are protected against tumourigenesis. | ||
| 700 | 1 | |a Biemond, I. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hardwick, J. C. H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hommes, D. W. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Muncan, V. |e VerfasserIn |4 aut | |
| 700 | 1 | |a van den Brink, G. R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Büller, N. V. J. A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hoff, E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dihal, A. A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a van der Poll, T. |e VerfasserIn |4 aut | |
| 700 | 1 | |a van Zoelen, M. A. D. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bierhaus, Angelika |d 1962-2012 |e VerfasserIn |0 (DE-588)1038392292 |0 (DE-627)757235271 |0 (DE-576)175591814 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Oncogene |d London : Springer Nature, 1997 |g 32(2013), 9, Seite 1202-1206 |h Online-Ressource |w (DE-627)320469964 |w (DE-600)2008404-3 |w (DE-576)096188715 |x 1476-5594 |7 nnas |a Rage signalling promotes intestinal tumourigenesis |
| 773 | 1 | 8 | |g volume:32 |g year:2013 |g number:9 |g pages:1202-1206 |g extent:5 |a Rage signalling promotes intestinal tumourigenesis |
| 856 | 4 | 0 | |u https://doi.org/10.1038/onc.2012.119 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/onc2012119 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210302 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1038392292 |a Bierhaus, Angelika |m 1038392292:Bierhaus, Angelika |d 50000 |e 50000PB1038392292 |k 0/50000/ |p 7 | ||
| 999 | |a KXP-PPN1750102196 |e 3879868891 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"recId":"1750102196","note":["Published online 2 April 2012","Gesehen am 08.10.2021"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"Rage signalling promotes intestinal tumourigenesis","title":"Rage signalling promotes intestinal tumourigenesis"}],"person":[{"given":"Jarom","family":"Heijmans","role":"aut","display":"Heijmans, Jarom","roleDisplay":"VerfasserIn"},{"given":"I.","family":"Biemond","role":"aut","roleDisplay":"VerfasserIn","display":"Biemond, I."},{"family":"Hardwick","given":"J. C. H.","roleDisplay":"VerfasserIn","display":"Hardwick, J. C. H.","role":"aut"},{"family":"Hommes","given":"D. W.","display":"Hommes, D. W.","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Muncan, V.","roleDisplay":"VerfasserIn","role":"aut","family":"Muncan","given":"V."},{"given":"G. R.","family":"van den Brink","role":"aut","roleDisplay":"VerfasserIn","display":"van den Brink, G. R."},{"roleDisplay":"VerfasserIn","display":"Büller, N. V. J. A.","role":"aut","family":"Büller","given":"N. V. J. A."},{"family":"Hoff","given":"E.","roleDisplay":"VerfasserIn","display":"Hoff, E.","role":"aut"},{"family":"Dihal","given":"A. A.","roleDisplay":"VerfasserIn","display":"Dihal, A. A.","role":"aut"},{"family":"van der Poll","given":"T.","display":"van der Poll, T.","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"van Zoelen, M. A. D.","given":"M. A. D.","family":"van Zoelen"},{"given":"Angelika","family":"Bierhaus","role":"aut","display":"Bierhaus, Angelika","roleDisplay":"VerfasserIn"}],"relHost":[{"id":{"issn":["1476-5594"],"zdb":["2008404-3"],"eki":["320469964"]},"origin":[{"publisherPlace":"London ; Basingstoke","publisher":"Springer Nature ; Nature Publ. Group","dateIssuedKey":"1997","dateIssuedDisp":"1997-"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"subtitle":"including Oncogene reviews","title":"Oncogene","title_sort":"Oncogene"}],"recId":"320469964","language":["eng"],"note":["Gesehen am 18.03.05"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Rage signalling promotes intestinal tumourigenesisOncogene","part":{"extent":"5","text":"32(2013), 9, Seite 1202-1206","volume":"32","pages":"1202-1206","issue":"9","year":"2013"},"pubHistory":["Nachgewiesen 14.1997 -"]}],"physDesc":[{"extent":"5 S."}],"id":{"doi":["10.1038/onc.2012.119"],"eki":["1750102196"]},"origin":[{"dateIssuedDisp":"2013","dateIssuedKey":"2013"}],"name":{"displayForm":["J. Heijmans, N.V.J.A. Büller, E. Hoff, A.A. Dihal, T. van der Poll, M.A.D. van Zoelen, A. Bierhaus, I. Biemond, J.C.H. Hardwick, D.W. Hommes, V. Muncan, and G.R. van den Brink"]}} | ||
| SRT | |a HEIJMANSJARAGESIGNAL2013 | ||