Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system
CD95/CD95L mediated apoptosis is an important mechanism of immune homeostasis. It is instrumental for termination of an immune response and mainly be involved in peripheral tolerance. Dysregulation of the CD95/CD95L system leads to severe diseases. In this review, we present a survey of the role of...
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| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
28 June 2003
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| In: |
Seminars in immunology
Year: 2003, Volume: 15, Issue: 3, Pages: 145-157 |
| ISSN: | 1096-3618 |
| DOI: | 10.1016/S1044-5323(03)00030-7 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S1044-5323(03)00030-7 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1044532303000307 
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| Author Notes: | Min Li-Weber, Peter H. Krammer |
MARC
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| 520 | |a CD95/CD95L mediated apoptosis is an important mechanism of immune homeostasis. It is instrumental for termination of an immune response and mainly be involved in peripheral tolerance. Dysregulation of the CD95/CD95L system leads to severe diseases. In this review, we present a survey of the role of the CD95/CD95L system in the immune system and, particularly, focus on the signals and transcription factors (NF-AT, Egr, NF-κB, AP-1, c-Myc, Nur77, IRFs, SP-1, ALG-4, RORγt, and CIITA) involved in CD95L expression. It should also be evident from this review that a profound insight into the molecular mechanisms of CD95L activation should allow to explore potential therapeutic means to treat CD95/CD95L-dependent diseases. | ||
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