Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks
The coronavirus disease 2019 (COVID-19) pandemic has claimed the lives of over one million people worldwide. The causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a member of the Coronaviridae family of viruses that can cause respiratory infections of varying severity...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2021
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| In: |
Cell
Year: 2021, Jahrgang: 184, Heft: 1, Pages: 120-132.e14 |
| ISSN: | 1097-4172 |
| DOI: | 10.1016/j.cell.2020.12.006 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cell.2020.12.006 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0092867420316767 
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| Verfasserangaben: | William M. Schneider, Joseph M. Luna, H. -Heinrich Hoffmann, Francisco J. Sánchez-Rivera, Andrew A. Leal, Alison W. Ashbrook, Jérémie Le Pen, Inna Ricardo-Lax, Eleftherios Michailidis, Avery Peace, Ansgar F. Stenzel, Scott W. Lowe, Margaret R. MacDonald, Charles M. Rice, and John T. Poirier |
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| 245 | 1 | 0 | |a Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks |c William M. Schneider, Joseph M. Luna, H. -Heinrich Hoffmann, Francisco J. Sánchez-Rivera, Andrew A. Leal, Alison W. Ashbrook, Jérémie Le Pen, Inna Ricardo-Lax, Eleftherios Michailidis, Avery Peace, Ansgar F. Stenzel, Scott W. Lowe, Margaret R. MacDonald, Charles M. Rice, and John T. Poirier |
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| 520 | |a The coronavirus disease 2019 (COVID-19) pandemic has claimed the lives of over one million people worldwide. The causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a member of the Coronaviridae family of viruses that can cause respiratory infections of varying severity. The cellular host factors and pathways co-opted during SARS-CoV-2 and related coronavirus life cycles remain ill defined. To address this gap, we performed genome-scale CRISPR knockout screens during infection by SARS-CoV-2 and three seasonal coronaviruses (HCoV-OC43, HCoV-NL63, and HCoV-229E). These screens uncovered host factors and pathways with pan-coronavirus and virus-specific functional roles, including major dependency on glycosaminoglycan biosynthesis, sterol regulatory element-binding protein (SREBP) signaling, bone morphogenetic protein (BMP) signaling, and glycosylphosphatidylinositol biosynthesis, as well as a requirement for several poorly characterized proteins. We identified an absolute requirement for the VMP1, TMEM41, and TMEM64 (VTT) domain-containing protein transmembrane protein 41B (TMEM41B) for infection by SARS-CoV-2 and three seasonal coronaviruses. This human coronavirus host factor compendium represents a rich resource to develop new therapeutic strategies for acute COVID-19 and potential future coronavirus pandemics. | ||
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| 650 | 4 | |a host factors | |
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| 700 | 1 | |a Luna, Joseph M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hoffmann, H. -Heinrich |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sánchez-Rivera, Francisco J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Leal, Andrew A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ashbrook, Alison W. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Le Pen, Jérémie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ricardo-Lax, Inna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Michailidis, Eleftherios |e VerfasserIn |4 aut | |
| 700 | 1 | |a Peace, Avery |e VerfasserIn |4 aut | |
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| 700 | 1 | |a MacDonald, Margaret R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rice, Charles M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Poirier, John T. |e VerfasserIn |4 aut | |
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