Molecular mechanisms of death-receptor-mediated apoptosis
Apoptosis, also called “programmed cell death”, can be induced by a variety of stimuli including activation of death receptors by the corresponding death ligands. Death receptors are a subgroup of the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor superfamily and are characterized by...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
04 January 2001
|
| In: |
ChemBioChem
Year: 2001, Jahrgang: 2, Heft: 1, Pages: 20-29 |
| ISSN: | 1439-7633 |
| DOI: | 10.1002/1439-7633(20010105)2:1<20::AID-CBIC20>3.0.CO;2-X |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/1439-7633(20010105)2:1<20::AID-CBIC20>3.0.CO;2-X Verlag, lizenzpflichtig, Volltext: https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/1439-7633%2820010105%292%3A1%3C20%3A%3AAID-CBIC20%3E3.0.CO%3B2-X 
|
| Verfasserangaben: | Ute Sartorius, Ingo Schmitz, and Peter H. Krammer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1750181770 | ||
| 003 | DE-627 | ||
| 005 | 20220819124421.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210303s2001 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/1439-7633(20010105)2:1<20::AID-CBIC20>3.0.CO;2-X |2 doi | |
| 035 | |a (DE-627)1750181770 | ||
| 035 | |a (DE-599)KXP1750181770 | ||
| 035 | |a (OCoLC)1341396562 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Sartorius, Ute |d 1969- |e VerfasserIn |0 (DE-588)118201891 |0 (DE-627)694759899 |0 (DE-576)291766862 |4 aut | |
| 245 | 1 | 0 | |a Molecular mechanisms of death-receptor-mediated apoptosis |c Ute Sartorius, Ingo Schmitz, and Peter H. Krammer |
| 264 | 1 | |c 04 January 2001 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.03.2021 | ||
| 520 | |a Apoptosis, also called “programmed cell death”, can be induced by a variety of stimuli including activation of death receptors by the corresponding death ligands. Death receptors are a subgroup of the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor superfamily and are characterized by a death domain, which is required for signal transduction. Upon apoptosis induction, caspases, a family of aspartyl-specific cysteine proteases, are activated, which are the main executioners of apoptosis. Finally, specific death substrates are cleaved, resulting in the morphologic features of apoptosis. Depending on the cell type, activation of mitochondria is of central significance for apoptosis induction. This signaling pathway can be modulated by different pro- and anti-apoptotic proteins such as Bax and Bcl-2, which are localized at the mitochondria. Furthermore, apoptosis initiation can be prevented at the death receptor level by FLICE (caspase-8)-inhibitory proteins (FLIPs). Deregulation of apoptosis is associated with diseases like cancer, autoimmunity, and AIDS. Therefore, the elucidation of cell death pathways and the identification of modulators of apoptosis have many therapeutic implications. | ||
| 650 | 4 | |a apoptosis | |
| 650 | 4 | |a biological signal transduction | |
| 650 | 4 | |a CD95 | |
| 650 | 4 | |a receptors | |
| 650 | 4 | |a tumor therapy | |
| 700 | 1 | |a Schmitz, Ingo |d 1971- |e VerfasserIn |0 (DE-588)122317068 |0 (DE-627)705859169 |0 (DE-576)293216517 |4 aut | |
| 700 | 1 | |a Krammer, Peter H. |d 1946- |e VerfasserIn |0 (DE-588)121766373 |0 (DE-627)081520255 |0 (DE-576)292873417 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t ChemBioChem |d Weinheim : Wiley-VCH, 2000 |g 2(2001), 1, Seite 20-29 |h Online-Ressource |w (DE-627)320603539 |w (DE-600)2020469-3 |w (DE-576)091208505 |x 1439-7633 |7 nnas |a Molecular mechanisms of death-receptor-mediated apoptosis |
| 773 | 1 | 8 | |g volume:2 |g year:2001 |g number:1 |g pages:20-29 |g extent:10 |a Molecular mechanisms of death-receptor-mediated apoptosis |
| 856 | 4 | 0 | |u https://doi.org/10.1002/1439-7633(20010105)2:1<20::AID-CBIC20>3.0.CO;2-X |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/1439-7633%2820010105%292%3A1%3C20%3A%3AAID-CBIC20%3E3.0.CO%3B2-X |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210303 | ||
| 993 | |a Article | ||
| 994 | |a 2001 | ||
| 998 | |g 121766373 |a Krammer, Peter H. |m 121766373:Krammer, Peter H. |d 50000 |e 50000PK121766373 |k 0/50000/ |p 3 |y j | ||
| 999 | |a KXP-PPN1750181770 |e 3880645930 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Molecular mechanisms of death-receptor-mediated apoptosis","title":"Molecular mechanisms of death-receptor-mediated apoptosis"}],"person":[{"family":"Sartorius","given":"Ute","roleDisplay":"VerfasserIn","display":"Sartorius, Ute","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Schmitz, Ingo","given":"Ingo","family":"Schmitz"},{"given":"Peter H.","family":"Krammer","role":"aut","display":"Krammer, Peter H.","roleDisplay":"VerfasserIn"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 03.03.2021"],"recId":"1750181770","language":["eng"],"origin":[{"dateIssuedDisp":"04 January 2001","dateIssuedKey":"2001"}],"id":{"doi":["10.1002/1439-7633(20010105)2:1<20::AID-CBIC20>3.0.CO;2-X"],"eki":["1750181770"]},"name":{"displayForm":["Ute Sartorius, Ingo Schmitz, and Peter H. Krammer"]},"physDesc":[{"extent":"10 S."}],"relHost":[{"title":[{"title":"ChemBioChem","subtitle":"an official journal of the EFMC","title_sort":"ChemBioChem"}],"titleAlt":[{"title":"a European journal of chemical biology"}],"part":{"issue":"1","pages":"20-29","year":"2001","extent":"10","text":"2(2001), 1, Seite 20-29","volume":"2"},"pubHistory":["1.2000,1 (July) -"],"recId":"320603539","language":["eng"],"disp":"Molecular mechanisms of death-receptor-mediated apoptosisChemBioChem","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Fortsetzung der Druck-Ausgabe","Gesehen am 10.11.2022"],"id":{"issn":["1439-7633"],"zdb":["2020469-3"],"eki":["320603539"],"doi":["10.1002/(ISSN)1439-7633"]},"origin":[{"dateIssuedDisp":"[2000]-","publisher":"Wiley-VCH","publisherPlace":"Weinheim"}],"name":{"displayForm":["European Federation for Medicinal chemistry and Chemical biology"]},"physDesc":[{"extent":"Online-Ressource"}]}]} | ||
| SRT | |a SARTORIUSUMOLECULARM0420 | ||