Regulation of death receptor-mediated apoptosis pathways
Apoptosis or programmed cell death can be induced by a variety of stimuli including activation of death receptors. This subgroup of the TNF/NGF-receptor-superfamily activates caspases, a family of aspartyl-specific cysteine-proteases, which are the main executioners of apoptosis. Depending on the ce...
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
21 December 2000
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| In: |
International journal of biochemistry & cell biology
Year: 2000, Jahrgang: 32, Heft: 11/12, Pages: 1123-1136 |
| ISSN: | 1878-5875 |
| DOI: | 10.1016/S1357-2725(00)00048-0 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S1357-2725(00)00048-0 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1357272500000480 
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| Verfasserangaben: | Ingo Schmitz, Sabine Kirchhoff, Peter H Krammer |
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| 520 | |a Apoptosis or programmed cell death can be induced by a variety of stimuli including activation of death receptors. This subgroup of the TNF/NGF-receptor-superfamily activates caspases, a family of aspartyl-specific cysteine-proteases, which are the main executioners of apoptosis. Depending on the cell type, signalling pathways downstream of the death receptors can be modulated by different proteins such as Bcl-2, FLIPs, chaperones and kinases. Deregulation of apoptosis has been associated with diseases as cancer, autoimmunity and AIDS. Therefore, the identification of modulators of apoptosis has several therapeutic implications. | ||
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