A prospective, randomized, double-masked trial on radiation therapy for neovascular age-related macular degeneration (RAD study)
Objective - To determine the efficacy of external beam radiation therapy on choroidal neovascularization (CNV) secondary to age-related macular degeneration (ARMD). - Design - Multicenter, parallel, randomized, double-masked clinical trial performed at nine ophthalmic and radiotherapeutic centers. -...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1999
|
| In: |
Ophthalmology
Year: 1999, Jahrgang: 106, Heft: 12, Pages: 2239-2247 |
| ISSN: | 1549-4713 |
| DOI: | 10.1016/S0161-6420(99)90522-5 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0161-6420(99)90522-5 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0161642099905225 
|
| Verfasserangaben: | The Radiation Therapy for Age-related Macular Degeneration (RAD) Study Group: [Hans Eberhard Völcker, F.G. Holz, R. Engenhart-Cabillic, K. Unnebrink, C. Bellmann, J. Debus, M. Pritsch, M. Wannenmacher] |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 175024053X | ||
| 003 | DE-627 | ||
| 005 | 20240613142135.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210303s1999 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/S0161-6420(99)90522-5 |2 doi | |
| 035 | |a (DE-627)175024053X | ||
| 035 | |a (DE-599)KXP175024053X | ||
| 035 | |a (OCoLC)1341396932 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Völcker, Hans Eberhard |d 1943- |e VerfasserIn |0 (DE-588)107745676X |0 (DE-627)836712927 |0 (DE-576)446290807 |4 aut | |
| 245 | 1 | 2 | |a A prospective, randomized, double-masked trial on radiation therapy for neovascular age-related macular degeneration (RAD study) |c The Radiation Therapy for Age-related Macular Degeneration (RAD) Study Group: [Hans Eberhard Völcker, F.G. Holz, R. Engenhart-Cabillic, K. Unnebrink, C. Bellmann, J. Debus, M. Pritsch, M. Wannenmacher] |
| 264 | 1 | |c 1999 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online: 25 August 2003 | ||
| 500 | |a Gesehen am 03.03.2021 | ||
| 520 | |a Objective - To determine the efficacy of external beam radiation therapy on choroidal neovascularization (CNV) secondary to age-related macular degeneration (ARMD). - Design - Multicenter, parallel, randomized, double-masked clinical trial performed at nine ophthalmic and radiotherapeutic centers. - Participants - Two hundred five patients were randomly assigned either to treatment with 8 fractions of 2 Gy external beam irradiation (n = 101) or to control with 8 fractions of 0 Gy (sham treatment, n = 104). Both patients and ophthalmologists were masked with regard to applied treatment. Patients with subfoveal classic or occult CNV, visual acuity of 20/320 or greater on the Early Treatment Diabetic Retinopathy Study chart, lesion size of 6 disc areas or less, history of visual symptoms of 6 months or less, and absence of foveal hemorrhage were recruited. - Intervention - In the treatment group, external beam irradiation with 8 fractions of 2 Gy was performed, whereas in the control group, sham treatment with 8 fractions of 0 Gy was applied. - Main outcome measures - Primary outcome measure was the difference in visual acuity between baseline and after 1 year of follow-up. - Results - One hundred eighty-three patients (89.3%) completed the 1-year follow-up. The mean reduction in visual acuity was 3.5 ± 4.7 lines in 88 patients of the 8- × 2-Gy treatment group and 3.7 ± 3.8 lines in 95 patients of the 8- × 0-Gy control group. This difference was not statistically significant (P = 0.53, Mann-Whitney U test). At 1 year, 51.1% of treated patients and 52.6% of control subjects lost three or more lines (P = 0.88). Visual acuity in the presence of classic CNV dropped by 3.7 ± 4.4 lines in 33 patients of the treatment group versus 4.3 ± 3.9 lines in 36 patients of the control group (P = 0.47). Visual acuity in 114 patients with occult CNV dropped by 3.4 ± 4.9 in the treatment group (55 patients) versus 3.4 ± 3.8 lines in the control group (59 patients) (P = 0.80). - Conclusions - In this randomized study, radiation therapy at a dose of 16 Gy applied in 8 fractions of 2 Gy provided no benefit as a treatment for subfoveal CNV secondary to ARMD at 1 year. | ||
| 700 | 1 | |a Holz, Frank G. |d 1962- |e VerfasserIn |0 (DE-588)114875855 |0 (DE-627)549545182 |0 (DE-576)289811589 |4 aut | |
| 700 | 1 | |a Unnebrink, Kristina |e VerfasserIn |0 (DE-588)111313299X |0 (DE-627)867098333 |0 (DE-576)18580988X |4 aut | |
| 700 | 1 | |a Bellmann, Caren |d 1968- |e VerfasserIn |0 (DE-588)113754744 |0 (DE-627)654711011 |0 (DE-576)339053046 |4 aut | |
| 700 | 1 | |a Debus, Jürgen |d 1964- |e VerfasserIn |0 (DE-588)1022671421 |0 (DE-627)717025780 |0 (DE-576)365774944 |4 aut | |
| 700 | 1 | |a Pritsch, Maria |d 1958- |e VerfasserIn |0 (DE-588)11816435X |0 (DE-627)694727121 |0 (DE-576)291747450 |4 aut | |
| 700 | 1 | |a Wannenmacher, Michael |d 1938-2015 |e VerfasserIn |0 (DE-588)115523588 |0 (DE-627)077305582 |0 (DE-576)289929717 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Ophthalmology |d Amsterdam [u.a.] : Elsevier, 1978 |g 106(1999), 12, Seite 2239-2247 |h Online-Ressource |w (DE-627)320526941 |w (DE-600)2015287-5 |w (DE-576)121465691 |x 1549-4713 |7 nnas |a A prospective, randomized, double-masked trial on radiation therapy for neovascular age-related macular degeneration (RAD study) |
| 773 | 1 | 8 | |g volume:106 |g year:1999 |g number:12 |g pages:2239-2247 |g extent:9 |a A prospective, randomized, double-masked trial on radiation therapy for neovascular age-related macular degeneration (RAD study) |
| 856 | 4 | 0 | |u https://doi.org/10.1016/S0161-6420(99)90522-5 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0161642099905225 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210303 | ||
| 993 | |a Article | ||
| 994 | |a 1999 | ||
| 998 | |g 115523588 |a Wannenmacher, Michael |m 115523588:Wannenmacher, Michael |d 910000 |d 911400 |e 910000PW115523588 |e 911400PW115523588 |k 0/910000/ |k 1/910000/911400/ | ||
| 998 | |g 11816435X |a Pritsch, Maria |m 11816435X:Pritsch, Maria |d 910000 |d 999701 |e 910000PP11816435X |e 999701PP11816435X |k 0/910000/ |k 1/910000/999701/ | ||
| 998 | |g 1022671421 |a Debus, Jürgen |m 1022671421:Debus, Jürgen |d 910000 |d 911400 |e 910000PD1022671421 |e 911400PD1022671421 |k 0/910000/ |k 1/910000/911400/ | ||
| 998 | |g 113754744 |a Bellmann, Caren |m 113754744:Bellmann, Caren |d 910000 |d 910900 |e 910000PB113754744 |e 910900PB113754744 |k 0/910000/ |k 1/910000/910900/ | ||
| 998 | |g 111313299X |a Unnebrink, Kristina |m 111313299X:Unnebrink, Kristina |d 910000 |d 999701 |e 910000PU111313299X |e 999701PU111313299X |k 0/910000/ |k 1/910000/999701/ | ||
| 998 | |g 114875855 |a Holz, Frank G. |m 114875855:Holz, Frank G. |d 910000 |d 910900 |e 910000PH114875855 |e 910900PH114875855 |k 0/910000/ |k 1/910000/910900/ | ||
| 998 | |g 107745676X |a Völcker, Hans Eberhard |m 107745676X:Völcker, Hans Eberhard |d 910000 |d 910900 |e 910000PV107745676X |e 910900PV107745676X |k 0/910000/ |k 1/910000/910900/ | ||
| 999 | |a KXP-PPN175024053X |e 3880803269 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["The Radiation Therapy for Age-related Macular Degeneration (RAD) Study Group: [Hans Eberhard Völcker, F.G. Holz, R. Engenhart-Cabillic, K. Unnebrink, C. Bellmann, J. Debus, M. Pritsch, M. Wannenmacher]"]},"id":{"doi":["10.1016/S0161-6420(99)90522-5"],"eki":["175024053X"]},"origin":[{"dateIssuedKey":"1999","dateIssuedDisp":"1999"}],"person":[{"display":"Völcker, Hans Eberhard","family":"Völcker","role":"aut","given":"Hans Eberhard"},{"family":"Holz","role":"aut","given":"Frank G.","display":"Holz, Frank G."},{"display":"Unnebrink, Kristina","family":"Unnebrink","role":"aut","given":"Kristina"},{"given":"Caren","role":"aut","family":"Bellmann","display":"Bellmann, Caren"},{"display":"Debus, Jürgen","role":"aut","given":"Jürgen","family":"Debus"},{"display":"Pritsch, Maria","family":"Pritsch","given":"Maria","role":"aut"},{"role":"aut","given":"Michael","family":"Wannenmacher","display":"Wannenmacher, Michael"}],"relHost":[{"title":[{"subtitle":"journal of the American Academy of Ophthalmology","title":"Ophthalmology","title_sort":"Ophthalmology"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"note":["Gesehen am 15.01.20"],"origin":[{"publisher":"Elsevier ; Acad.","dateIssuedKey":"1978","publisherPlace":"Amsterdam [u.a.] ; San Francisco, Calif.","dateIssuedDisp":"1978-"}],"disp":"A prospective, randomized, double-masked trial on radiation therapy for neovascular age-related macular degeneration (RAD study)Ophthalmology","recId":"320526941","physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["320526941"],"issn":["1549-4713"],"zdb":["2015287-5"]},"part":{"volume":"106","year":"1999","extent":"9","text":"106(1999), 12, Seite 2239-2247","issue":"12","pages":"2239-2247"},"pubHistory":["85.1978 -"],"corporate":[{"display":"American Academy of Ophthalmology","role":"isb"}]}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Available online: 25 August 2003","Gesehen am 03.03.2021"],"title":[{"title":"A prospective, randomized, double-masked trial on radiation therapy for neovascular age-related macular degeneration (RAD study)","title_sort":"prospective, randomized, double-masked trial on radiation therapy for neovascular age-related macular degeneration (RAD study)"}],"physDesc":[{"extent":"9 S."}],"recId":"175024053X"} | ||
| SRT | |a VOELCKERHAPROSPECTIV1999 | ||