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Ultraviolet irradiation suppresses T cell activation via blocking TCR-mediated ERK and NF-κB signaling pathways

UV irradiation is carcinogenic and immunosuppressive. Previous studies indicate that UV-mediated alteration of APCs and induction of suppressor T cells play a critical role in UV-induced immune suppression. In this study, we show that UV irradiation can directly (independently of APCs and suppressor...

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Hauptverfasser: Li-Weber, Min (VerfasserIn) , Krammer, Peter H. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: August 15, 2005
In: The journal of immunology
Year: 2005, Jahrgang: 175, Heft: 4, Pages: 2132-2143
ISSN:1550-6606
DOI:10.4049/jimmunol.175.4.2132
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4049/jimmunol.175.4.2132
Verlag, lizenzpflichtig, Volltext: https://www.jimmunol.org/content/175/4/2132
Volltext
Verfasserangaben:Min Li-Weber, Monika K. Treiber, Marco Giaisi, Katalin Palfi, Nadja Stephan, Simone Parg,and Peter H. Krammer
Beschreibung
Zusammenfassung:UV irradiation is carcinogenic and immunosuppressive. Previous studies indicate that UV-mediated alteration of APCs and induction of suppressor T cells play a critical role in UV-induced immune suppression. In this study, we show that UV irradiation can directly (independently of APCs and suppressor T cells) inhibit T cell activation by blocking TCR-mediated phosphorylation of ERK and IκB via overactivation of the p38 and JNK pathways. These events lead to the down-modulation of c-Jun, c-Fos, Egr-1, and NF-κB transcription factors and thereby inhibit production of cytokines, e.g., IL-2, IL-4, IFN-γ, and TNF-α, upon TCR stimulation. We also show that UV irradiation can suppress preactivated T cells, indicating that UV irradiation does not only impair T cell function in response to T cell activation, but can also have systemic effects that influence ongoing immune responses. Thus, our data provide an additional mechanism by which UV irradiation directly suppresses immune responses.
Beschreibung:Gesehen am 04.03.2021
Beschreibung:Online Resource
ISSN:1550-6606
DOI:10.4049/jimmunol.175.4.2132

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