Antibodies against glutamic acid decarboxylase: prevalence in neurological diseases
High prevalence of autoantibodies against glutamic acid decarboxylase (GAD-Ab) in stiff man syndrome (SMS) not only helps diagnosis, but also suggests immune mediated impairment of GABAergic functions. However, the presence of GAD-Ab has also been reported in other neurological syndromes. Therefore...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 01, 2001
|
| In: |
Journal of neurology, neurosurgery, and psychiatry
Year: 2001, Jahrgang: 71, Heft: 1, Pages: 100-103 |
| ISSN: | 1468-330X |
| DOI: | 10.1136/jnnp.71.1.100 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/jnnp.71.1.100 Verlag, lizenzpflichtig, Volltext: https://jnnp.bmj.com/content/71/1/100 
|
| Verfasserangaben: | H.-M. Meinck, L. Faber, N. Morgenthaler, J. Seissler, S. Maile, M. Butler, M. Solimena, P. DeCamilli, W.A. Scherbaum |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1750395088 | ||
| 003 | DE-627 | ||
| 005 | 20230427140035.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210304s2001 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1136/jnnp.71.1.100 |2 doi | |
| 035 | |a (DE-627)1750395088 | ||
| 035 | |a (DE-599)KXP1750395088 | ||
| 035 | |a (OCoLC)1341397041 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Meinck, Hans-Michael |e VerfasserIn |0 (DE-588)1048652114 |0 (DE-627)780862325 |0 (DE-576)402924983 |4 aut | |
| 245 | 1 | 0 | |a Antibodies against glutamic acid decarboxylase |b prevalence in neurological diseases |c H.-M. Meinck, L. Faber, N. Morgenthaler, J. Seissler, S. Maile, M. Butler, M. Solimena, P. DeCamilli, W.A. Scherbaum |
| 264 | 1 | |c July 01, 2001 | |
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.03.2021 | ||
| 520 | |a High prevalence of autoantibodies against glutamic acid decarboxylase (GAD-Ab) in stiff man syndrome (SMS) not only helps diagnosis, but also suggests immune mediated impairment of GABAergic functions. However, the presence of GAD-Ab has also been reported in other neurological syndromes. Therefore the prevalence of GAD-Ab was investigated in SMS, progressive encephalomyelitis with rigidity and myoclonus (PERM), and in other neurological diseases (OND). - Serum antibodies against the GAD isoforms, GAD65 and GAD67, were investigated with radioimmunoassays in 13 patients with SMS, nine with PERM, 279 consecutive patients with OND, and in 100 normal controls. - RESULTS Prevalence of GAD65Ab was around 80% in patients with SMS/PERM compared with 5% in patients with OND and 1% in normal controls. Prevalence of GAD67Ab was 60% in SMS/PERM, 2% in patients with OND, and 1% in normal controls. Raised GAD-Ab clustered in an OND subgroup with sporadic progressive ataxia, but not in OND subgroups with recognised neuroimmunological diseases. - In conclusion, increased GAD-Ab is neither a non-specific epiphenomenon of neuronal damage nor a common feature of recognised neuroimmunological disorders. In neurological diseases, GAD-Ab may be a pathogenetic agent or a marker for an ongoing autoimmune process, or both. | ||
| 650 | 4 | |a autoimmunity | |
| 650 | 4 | |a glutamic acid decarboxylase | |
| 650 | 4 | |a stiff man syndrome | |
| 700 | 1 | |a Faber, Lilian A. |d 1970- |e VerfasserIn |0 (DE-588)136130925 |0 (DE-627)694107301 |0 (DE-576)30084977X |4 aut | |
| 700 | 1 | |a Morgenthaler, N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Seissler, J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Maile, Silke |d 1970- |e VerfasserIn |0 (DE-588)121927393 |0 (DE-627)705705226 |0 (DE-576)292998147 |4 aut | |
| 700 | 1 | |a Butler, M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Solimena, M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a DeCamilli, P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Scherbaum, W. A. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neurology, neurosurgery, and psychiatry |d London : BMJ Publishing Group, 1944 |g 71(2001), 1, Seite 100-103 |h Online-Ressource |w (DE-627)271594691 |w (DE-600)1480429-3 |w (DE-576)078707617 |x 1468-330X |7 nnas |a Antibodies against glutamic acid decarboxylase prevalence in neurological diseases |
| 773 | 1 | 8 | |g volume:71 |g year:2001 |g number:1 |g pages:100-103 |g extent:4 |a Antibodies against glutamic acid decarboxylase prevalence in neurological diseases |
| 856 | 4 | 0 | |u https://doi.org/10.1136/jnnp.71.1.100 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://jnnp.bmj.com/content/71/1/100 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210304 | ||
| 993 | |a Article | ||
| 994 | |a 2001 | ||
| 998 | |g 1048652114 |a Meinck, Hans-Michael |m 1048652114:Meinck, Hans-Michael |d 910000 |d 911100 |e 910000PM1048652114 |e 911100PM1048652114 |k 0/910000/ |k 1/910000/911100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1750395088 |e 3881392769 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"4 S."}],"relHost":[{"origin":[{"publisherPlace":"London","publisher":"BMJ Publishing Group","dateIssuedKey":"1944","dateIssuedDisp":"1944-"}],"id":{"zdb":["1480429-3"],"eki":["271594691"],"issn":["1468-330X"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Journal of neurology, neurosurgery, and psychiatry","subtitle":"a peer review journal for health professionals and researchers in all areas of neurology","title_sort":"Journal of neurology, neurosurgery, and psychiatry"}],"pubHistory":["N.S. 7.1944,3 - 42.1979; 43.1980 -"],"part":{"extent":"4","text":"71(2001), 1, Seite 100-103","volume":"71","issue":"1","pages":"100-103","year":"2001"},"titleAlt":[{"title":"JNNP online"},{"title":"Journal of neurology, neurosurgery & psychiatry"}],"note":["Gesehen am 30.11.12","Beteil. Körp. früher: British Medical Association"],"disp":"Antibodies against glutamic acid decarboxylase prevalence in neurological diseasesJournal of neurology, neurosurgery, and psychiatry","type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"corporate":[{"role":"isb","display":"British Medical Association","roleDisplay":"Herausgebendes Organ"}],"recId":"271594691"}],"name":{"displayForm":["H.-M. Meinck, L. Faber, N. Morgenthaler, J. Seissler, S. Maile, M. Butler, M. Solimena, P. DeCamilli, W.A. Scherbaum"]},"origin":[{"dateIssuedDisp":"July 01, 2001","dateIssuedKey":"2001"}],"id":{"doi":["10.1136/jnnp.71.1.100"],"eki":["1750395088"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 04.03.2021"],"language":["eng"],"recId":"1750395088","person":[{"display":"Meinck, Hans-Michael","roleDisplay":"VerfasserIn","role":"aut","family":"Meinck","given":"Hans-Michael"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Faber, Lilian A.","given":"Lilian A.","family":"Faber"},{"family":"Morgenthaler","given":"N.","display":"Morgenthaler, N.","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Seissler","given":"J.","roleDisplay":"VerfasserIn","display":"Seissler, J.","role":"aut"},{"family":"Maile","given":"Silke","display":"Maile, Silke","roleDisplay":"VerfasserIn","role":"aut"},{"given":"M.","family":"Butler","role":"aut","roleDisplay":"VerfasserIn","display":"Butler, M."},{"display":"Solimena, M.","roleDisplay":"VerfasserIn","role":"aut","family":"Solimena","given":"M."},{"given":"P.","family":"DeCamilli","role":"aut","display":"DeCamilli, P.","roleDisplay":"VerfasserIn"},{"given":"W. A.","family":"Scherbaum","role":"aut","roleDisplay":"VerfasserIn","display":"Scherbaum, W. A."}],"title":[{"subtitle":"prevalence in neurological diseases","title":"Antibodies against glutamic acid decarboxylase","title_sort":"Antibodies against glutamic acid decarboxylase"}]} | ||
| SRT | |a MEINCKHANSANTIBODIES0120 | ||