Transforming growth factor β can mediate apoptosis via the expression of TRAIL in human hepatoma cells
Transforming growth factor β (TGF-β) has been shown to induce apoptotic cell death in normal and transformed hepatocytes. However, the exact mechanism through which TGF-β induces cell death is still unknown. We examined a potential role of various death receptor/ligand systems in TGF-β-induced apopt...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 June 2005
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| In: |
Hepatology
Year: 2005, Jahrgang: 42, Heft: 1, Pages: 183-192 |
| ISSN: | 1527-3350 |
| DOI: | 10.1002/hep.20757 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/hep.20757 Verlag, lizenzpflichtig, Volltext: https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.20757 
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| Verfasserangaben: | Kerstin Herzer, Tom M. Ganten, Henning Schulze‐Bergkamen, Anne Grosse‐Wilde, Ronald Koschny, Peter H. Krammer, and Henning Walczak |
MARC
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| 520 | |a Transforming growth factor β (TGF-β) has been shown to induce apoptotic cell death in normal and transformed hepatocytes. However, the exact mechanism through which TGF-β induces cell death is still unknown. We examined a potential role of various death receptor/ligand systems in TGF-β-induced apoptosis and identified the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a mediator of TGF-β-induced apoptosis in hepatoma cells. TGF-β-induced apoptosis is significantly impaired upon blockage of TRAIL. We show that TRAIL is upregulated in hepatoma cells upon treatment with TGF-β, whereas TRAIL receptor levels remain unchanged. In conclusion, our results provide evidence that the TRAIL system is critically involved in TGF-β-induced cell death in liver pathology. | ||
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